Abstract: The present invention provides substituted 2-aminopyridines of formula I, wherein R1, A1, W, X, and Y are as defined in the specification, useful in treating cell proliferative disorders.

Abstract: An air-oxygen hydrogen sulphide burner (108) fires into a furnace (102). The burner comprises a main passage for combustion-supporting gas containing air (112), a multiplicity of spaced apart outer elongate fluid-conducting open ended tubes extending in parallel with each other along the main passage, each of the outlet tubes surrounding at least at the distal end of the burner a respective inner elongate fluid-conducting open ended tube, the inner tubes extending in parallel with one another, a first inlet to the burner for oxygen or oxygen-enriched air, and a second inlet to the burner for feed gas containing hydrogen sulphide, the first inlet communicating with the inner tubs, and the second inlets communicating with the outer tubes.

Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4).

Abstract: An air-oxygen hydrogen sulphide burner (108) fires into a furnace (102). The burner comprises a main passage for combustion-supporting gas containing air (112), a multiplicity of spaced apart outer elongate fluid-conducting open ended tubes extending in parallel with each other along the main passage, each of the outlet tubes surrounding at least at the distal end of the burner a respective inner elongate fluid-conducting open ended tube, the inner tubes extending in parallel with one another, a first inlet to the burner for oxygen or oxygen-enriched air, and a second inlet to the burner for feed gas containing hydrogen sulphide, one of the first and second inlets communicating with the outer tubes, and the other of the first and second inlets communicating with the inner tubes.

Abstract: An auxiliary container (10) adapted for unintrusive coupling with a conventional medication container (12), such as pill bottle, cream tube, or spray can, wherein the auxiliary container (10) provides an independent storage space (26) which does not require breaking a seal of, removing, or replacing an existing lid (70) or cap of the conventional container (12). In one contemplated use, for example, the auxiliary container (10) is used to store small doses of a supplementary medication (14), such as aspirin, in close association with a primary medication (e.g., a heart medicine such as nitroglycerine), such that both are conveniently available and accessible for immediate use. In a preferred first embodiment, the auxiliary container (10) broadly comprises a body (16); a lid (18); a closure mechanism (20); and a coupling mechanism (22).

Abstract: An air-oxygen hydrogen sulphide burner (108) fires into a furnace (102). The burner comprises a main passage for combustion-supporting gas containing air (112), a multiplicity of spaced apart outer elongate fluid-conducting open ended tubes extending in parallel with each other along the main passage, each of the outlet tubes surrounding at least at the distal end of the burner a respective inner elongate fluid-conducting open ended tube, the inner tubes extending in parallel with one another, a first inlet to the burner for oxygen or oxygen-enriched air, and a second inlet to the burner for feed gas containing hydrogen sulphide, the first inlet communicating with the inner tubs, and the second inlets communicating with the outer tubes.

Abstract: An excavation fluid composition useful for enlarging a cavity in the earth includes a synthetic polymer and sodium silicate. The excavation fluid composition is formulated so as to enable the fluid in contact with unstable or sandy soils in the selected areas of the excavation to react and form silicate-based derivatives with lesser solubility, and movement and thus improve soil stability at the excavation wall.

Abstract: Non-slip ergonomic pads are disposed on opposite sides of the upper surface of a toilet seat for supporting the gluteus maximus of a user while helping to align the pelvis and spine when the user is seated on the toilet seat. The pads are formed of a durable non-slip material which deforms slightly when sat upon and has a memory to return to its original form when the pressure of the user seated on the toilet seat is removed. The pads may include a single layer or multiple layers of open celled sponge rubber or other material. When the pads have multiple layers, the layers may exhibit a continuous gradient of values of indentation force deflection. The material should be of substantially uniform thickness so as to provide uniform pressure distribution and firm support. The pads have non-slip characteristics without being sticky to the touch. The pads may have a cloth surface layer to provide a printable surface to contain printing, advertising or a design.

Abstract: Compositions and methods useful in creating boreholes, tunnels and other excavations in unstable soils and earth formations, especially those composed partially or wholly of sand, gravel or other granular or permeable material are disclosed. The fluids include a polymer, and a soluble silicate ion source. The fluids of the invention, when used according to the methods of the invention, have unique dual functionality as excavating fluids and as earth-grouting or soil-hardening compositions.

Abstract: Improved self-cleaning brushes (10, 44, 64) are provided which include a brush body (12, 46, 66) having a bristle-supporting portion (16, 50, 70) supporting outwardly extending bristles (18, 54, 72). One or more apertured cleaning sheet(s) (36, 56, 76) are mounted on the brushes so as to receive the bristles (18, 54, 72) therethrough. When it is desired to clean the brush (10, 44, 64), the uppermost cleaning sheet (36, 56, 76) is grasped and pulled outwardly and off of the bristles (18, 54, 72), thereby removing hair and other debris from the bristles (18, 54, 72). Preferably, a multiple sheet pad (20, 52, 74) of cleaning sheets (36, 56, 76) are provided, each with perforation lines (38, 57, 80) and grasping tabs (42, 58, 78), to facilitate lift-off removal of the individual cleaning sheets (36, 56, 76).