Patents by Inventor Scott A. Savage

Scott A. Savage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210094970
    Abstract: The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I: or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.
    Type: Application
    Filed: May 15, 2020
    Publication date: April 1, 2021
    Applicant: Genentech, Inc.
    Inventors: Paroma Chakravarty, Chong Han, Sean M. Kelly, Karthik Nagapudi, Scott Savage
  • Publication number: 20210069192
    Abstract: The invention relates to methods for treating chronic liver disease, in particular nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), with neutrophil elastase inhibitors. The invention further relates to pharmaceutical compositions comprising neutrophil elastase inhibitors.
    Type: Application
    Filed: September 21, 2020
    Publication date: March 11, 2021
    Applicant: pH Pharma Co., Ltd.
    Inventors: Sanjeev SATYAL, Brian ROBERTS, Xueyan WANG, Scott SAVAGE, Hoyoung HUH
  • Publication number: 20200399286
    Abstract: The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I: or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.
    Type: Application
    Filed: May 15, 2020
    Publication date: December 24, 2020
    Applicant: Genentech, Inc.
    Inventors: Paroma Chakravarty, Chong Han, Sean M. Kelly, Karthik Nagapudi, Scott Savage
  • Patent number: 10870626
    Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: December 22, 2020
    Assignees: F. Hoffman-La Roche AG, Genentech, Inc.
    Inventors: Francis Gosselin, Chong Han, Hans Iding, Reinhard Reents, Scott Savage, Beat Wirz
  • Patent number: 10806735
    Abstract: The invention relates to methods for treating chronic liver disease, in particular nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), with neutrophil elastase inhibitors. The invention further relates to pharmaceutical compositions comprising neutrophil elastase inhibitors.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: October 20, 2020
    Assignee: pH Pharma Co., Ltd.
    Inventors: Sanjeev Satyal, Brian Roberts, Xueyan Wang, Scott Savage, Hoyoung Huh
  • Patent number: 10781219
    Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: September 22, 2020
    Assignee: Genentech, Inc.
    Inventors: Francis Gosselin, Chong Han, Theresa Cravillion, Sean M. Kelly, Scott Savage
  • Publication number: 20200223852
    Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
    Type: Application
    Filed: July 19, 2018
    Publication date: July 16, 2020
    Inventors: Burcu Selin Aytar, Alina Borovika, Collin Chan, Joerg Deerberg, Nathan R. Domagalski, Martin D. Eastgate, Yu Fan, Michael David Bengt Fenster, Robert V. Forest, Francisco Gonzalez-Bobes, Rebecca A. Green, Matthew R. Hickey, Nathaniel David Kopp, Thomas E. La Cruz, Kathleen Lauser, Hong Geun Lee, David K. Leahy, Helen Y. Luo, Thomas M. Razler, Scott A. Savage, Chris Sfouggatakis, Maxime C.D. Soumeillant, Serge Zaretsky, Bin Zheng, Ye Zhu
  • Publication number: 20200010428
    Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 9, 2020
    Inventors: Francis Gosselin, Chong Han, Hans Iding, Reinhard Reents, Scott Savage, Beat Wirz
  • Patent number: 10494400
    Abstract: The present disclosure relates to methods for making asunaprevir, useful treatment of Hepatitis C virus (HCV) infection, and its intermediates.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: December 3, 2019
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Savage, Nathan R. Domagalski, Brendan Mack, Purushotham Vemishetti, Yuping Qiu, Michael Fenster, Daniel M. Hallow, Glenn Ferreira, Amanda Rogers, Sha Lou, Lindsay Hobson
  • Patent number: 10457648
    Abstract: The present disclosure relates to processes for preparing (cyclopentyl[d]pyrimidin-4-yl)piperazine compounds, and more particularly relates to processes for preparing (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d] pyrimidin-4-yl)piperazine and N-protected derivatives thereof, which may be used as an intermediate in the synthesis of Ipatasertib (i.e., (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)-propan-1-one). The present disclosure additionally relates to various compounds that are intermediates employed in these processes.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: October 29, 2019
    Assignees: GENENTECH INC., F. HOFFMANN-LA ROCHE AG
    Inventors: Francis Gosselin, Chong Han, Hans Iding, Reinhard Reents, Scott Savage, Beat Wirz
  • Publication number: 20190321364
    Abstract: The invention relates to methods for treating chronic liver disease, in particular nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), with neutrophil elastase inhibitors. The invention further relates to pharmaceutical compositions comprising neutrophil elastase inhibitors.
    Type: Application
    Filed: April 22, 2019
    Publication date: October 24, 2019
    Applicant: pH Pharma Co., Ltd.
    Inventors: Sanjeev Satyal, Brian Roberts, Xueyan Wang, Scott Savage, Hoyoung Huh
  • Publication number: 20190292201
    Abstract: Methods of making benzoxazepin oxazolidinone compounds as well as synthetic intermediates are described, including compound 18, having the structure:
    Type: Application
    Filed: June 14, 2019
    Publication date: September 26, 2019
    Applicant: Genentech, Inc.
    Inventors: Francis GOSSELIN, Chong HAN, Theresa CRAVILLION, Sean M. KELLY, Scott SAVAGE
  • Patent number: 10221208
    Abstract: A method for producing HIV maturation inhibitor compound is set forth using betulin as starting material, and utilizing Lossen rearrangement techniques.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 5, 2019
    Assignee: VIIV HEALTHCARE UK (NO.4) LIMITED
    Inventors: Adrian Ortiz, Maxime Soumeillant, Scott A. Savage, Neil A. Strotman, Martin D. Eastgate, Matthew W. Haley, Jeanne Ho, Jeffrey A. Nye, Zhongmin Xu, Susanne Kiau, Tamas Benkovics, Yichen Tan
  • Publication number: 20180339997
    Abstract: The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I: or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.
    Type: Application
    Filed: April 26, 2018
    Publication date: November 29, 2018
    Applicant: Genentech, Inc.
    Inventors: Paroma Chakravarty, Chong Han, Sean M. Kelly, Karthik Nagapudi, Scott Savage
  • Publication number: 20180155393
    Abstract: The present disclosure relates to methods for making asunaprevir, useful treatment of Hepatitis C virus (HCV) infection, and its intermediates.
    Type: Application
    Filed: June 23, 2015
    Publication date: June 7, 2018
    Inventors: Scott A. SAVAGE, Nathan R. DOMAGALSKI, Brendan MACK, Purushotham VEMISHETTI, Yuping QIU, Michael FENSTER, Daniel M. HALLOW, Glenn FERREIRA, Amanda ROGERS, Sha LOU, Lindsay HOBSON
  • Patent number: D880364
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 7, 2020
    Assignee: Harley-Davidson Motor Company Group, LLC
    Inventors: Dais Nagao, Mark Daniels, Frank Savage, Brad Richards, John Wolanski, Brent Ahlers, Michael DeCaluwe, Alexander John Bozmoski, Jeffrey Smith, Terry Rumpel, Brendon Smith, Timothy McChesney, Joseph Dennert, Michael Case, Kyle Wick, Matthew Paradise, Jeremy Lenzendorf, Carl Hoy, Richard Bradatsch, Michael Carlin, Matthew Mueller, Scott Matthews
  • Patent number: D880365
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 7, 2020
    Assignee: Harley-Davidson Motor Company Group, LLC
    Inventors: Ben McGinley, Frank Savage, Brad Richards, Alexander John Bozmoski, Jeffrey Smith, Terry Rumpel, Brendon Smith, Timothy McChesney, Joseph Dennert, Michael Case, Kyle Wick, Matthew Paradise, Jeremy Lenzendorf, Carl Hoy, Richard Bradatsch, Michael Carlin, Matthew Mueller, Scott Matthews, Robert Wong
  • Patent number: D880366
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 7, 2020
    Assignee: Harley-Davidson Motor Company Group, LLC
    Inventors: Chetan Shedjale, Frank Savage, Brad Richards, Michael DeCaluwe, Alexander John Bozmoski, Jeffrey Smith, Terry Rumpel, Brendon Smith, Timothy McChesney, Joseph Dennert, Michael Case, Kyle Wick, Matthew Paradise, Jeremy Lenzendorf, Carl Hoy, Richard Bradatsch, Michael Carlin, Matthew Mueller, Brent Ahlers, Anthony Senger, Matthew Gueller, Scott Matthews, John Wolanski
  • Patent number: D896274
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 15, 2020
    Assignee: Harley-Davidson Motor Company Group, LLC
    Inventors: Ben McGinley, Frank Savage, Brad Richards, Chetan Shedjale, Nathan Abplanalp, Stephen R. Collins, Richard W. Elchert, Dane Schwegman, Michael DeCaluwe, Brian Saiia, Scott Matthews
  • Patent number: D898772
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: October 13, 2020
    Assignee: Harley-Davidson Motor Company Group, LLC
    Inventors: Ben McGinley, Frank Savage, Brad Richards, Chetan Shedjale, Nathan Abplanalp, Stephen R. Collins, Richard W. Elchert, Dane Schwegman, Michael DeCaluwe, Brian Saiia, Scott Matthews