Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.

Abstract: An appliance (210) to heat a liquid, the appliance (21) including: a vessel (212) to receive the liquid to be heated, the vessel (212) having a generally central upright longitudinal axis (218), a bottom housing (220), and a side wall (222) extending upwardly from the bottom housing (220), with a portion of the bottom housing (220) and side wall (222) at least partly enclosing a chamber (234) within which the liquid is heated; and a heating element (238) in thermal communication with the chamber (234) so that heat generated by the element (238) can be delivered to the liquid via convection, wherein the housing (210) includes a deformable sealing member (268) sealingly associated with the element (238) to sealingly connect the element (238) and bottom housing (220), with the member (268) inhibiting transmission of sound from the chamber (234).

Abstract: A method for determining a trust indicator is provided. The method may include interpreting, via an Internet of Things Universal Identifier (IoT UID) processing circuit, an IoT UID corresponding to a device and identifying, via a record management circuit and based at least in part on the IoT UID, a record in a database corresponding to the device. The method may further include determining, via a trust analysis circuit and based at least in part on the record, a risk indicator of the device and transmitting, via an indicator provisioning circuit, the risk indicator.

Abstract: A fiber mat includes natural wood fibers formed into an elongated strip having an upper surface and a lower surface, the upper surface having a first plurality of channels extending into the elongated strip, each of the first plurality of channels having a channel depth being different in a central portion of the mat than in an edge portion of the mat.

Abstract: The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.

Abstract: An aircraft propulsion system is provided that includes a turbine engine and an exhaust gas heat exchanger. The exhaust gas heat exchanger includes a central conduit, an outer radial plenum, fluid conduits, and inter-conduit passages. The fluid conduits are disposed in a nested arrangement. Each fluid conduit has inner and outer radial walls that extend axially between the forward and aft ends. The inner and outer radial walls are radially separated to form an internal fluid passage. Each fluid conduit is radially spaced apart from adjacent fluid conduits to define an axially extending exhaust gas passages. The inter-conduit passages include at least one inter-conduit passage that provides fluid communication between the central conduit and a first fluid conduit, and at least one inter-conduit passage that provides fluid communication between first and second fluid conduits. A serpentine fluid flow path extends through the fluid conduits and the inter-conduit passages.

Abstract: Embodiments described herein relate to systems, devices, and methods of cleaning endoscopes or other instruments during surgical procedures, which can be used with a robotic system.

Abstract: Embodiments described herein relate to systems, devices, and methods of cleaning endoscopes or other instruments during surgical procedures. In some embodiments, a system or device can include a trocar including a trocar shaft and a cap that collectively define fluid and/or electrical passages. In some embodiments, a system or device can include obturators with a wiping element and/or an absorbent element configured to remove debris and moisture from the interior walls of trocars. In some embodiments, a system or device can include a trocar with a liquid and gas interconnect device and venting systems for cleaning instruments disposed in the trocar channel.

Abstract: An exoskeleton system that comprises: one or more actuator units, the one or more actuator units including an actuator; one or more sensors; and an exoskeleton device that includes: an actuation system, and a processor and memory, the memory storing instructions, that when executed by the processor, are configured to control the exoskeleton system to: cause actuation of the actuator of the one or more actuator units.

Abstract: Disclosed herein are improved assays, cartridges, kits, and methods of use thereof for detecting biomarkers, e.g., one or more biomarkers of brain injury, including, without limitation, biomarkers of acquired brain injury (ABI), such as, traumatic brain injury (TBI). The improved assays described herein may aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head (e.g., TBI) by detecting levels of a biomarker, such as UCH-L1, GFAP, or a combination thereof, in samples taken from a subject (e.g., a human subject).

Abstract: Exemplarily, a transformer includes a primary winding with two layers and a secondary winding with two layers. One turn in each of the first and second layers of the primary winding face one turn in each of the first and second layers in the secondary winding. Spacing between adjacent turns in the primary winding is constant. Spacing between adjacent turns in the secondary winding is constant.

Abstract: An introduced autonomous aerial vehicle can include multiple cameras for capturing images of a surrounding physical environment that are utilized for motion planning by an autonomous navigation system. In some embodiments, the cameras can be integrated into one or more rotor assemblies that house powered rotors to free up space within the body of the aerial vehicle. In an example embodiment, an aerial vehicle includes multiple upward-facing cameras and multiple downward-facing cameras with overlapping fields of view to enable stereoscopic computer vision in a plurality of directions around the aerial vehicle. Similar camera arrangements can also be implemented in fixed-wing aerial vehicles.

Abstract: Mounting bracket assemblies including first, second and third bracket members. The first bracket member includes first and second mounting surface portions. The first mounting surface portion engaging a suspension component. The second mounting surface portion defining a receiving zone for receiving a vehicle structure and is disposed along a first side of a first central plane of the receiving zone. A second bracket member includes first and second contact surface portions. The second bracket member is disposed along a second side of the first central plane and along a first side of a second central plane of the receiving zone. A third bracket member includes third and fourth contact surface portions. The third bracket member is disposed along the second side of the first central plane and along a second side of the second central plane. Suspension systems, kits and methods are also included.

Abstract: An aircraft propulsion system is provided that includes a turbine engine and an intercooler (IC). The turbine engine includes a source of non-hydrocarbon fuel, and a low pressure compressor having an LPC air inlet and outlet, and a high pressure compressor having an HPC air inlet and outlet. The intercooler has an IC air inlet, an IC air outlet, a U-shaped air passage, and crossflow tubes. The IC air inlet is in fluid communication with the LPC air outlet. The IC air outlet is in fluid communication with the HPC air inlet. The U-shaped air passage is in fluid communication with the IC air inlet and outlet. The crossflow tubes extend through the U-shaped air passage. The crossflow tubes are in fluid communication with the source of non-hydrocarbon fuel, and are configured to contain a flow of the non-hydrocarbon fuel therethrough.

Abstract: A medical device may include an implant having a plurality of openings, a tube having a lumen extending therethrough, a body extending from a distal portion of the tube to a proximal portion of the implant, such that the plurality of openings are in fluid communication with the lumen, and a grasping portion configured to be grasped by a second medical device.

Abstract: A medical system that includes a handle, a shaft extending distally from the handle, the shaft including one or more channels extending between the handle and a distal end of the shaft, and a cap assembly coupled to the distal end of the shaft. At least one of the one or more channels includes a working channel. The cap assembly includes an opening that is positioned in alignment with at least one of the one or more channels at the distal end of the shaft. The medical system includes a chamber that extends distally from the opening and a porous body movably disposed within the chamber. The chamber is positioned in alignment with the working channel, and the porous body is configured to transition from a compressed configuration when disposed inside the chamber to an expanded configuration upon extending outwardly from the chamber.

Abstract: An engine system is provided that includes an open propulsor rotor, an engine core assembly, a bypass flowpath and a condenser. The engine core assembly is configured to drive rotation of the open propulsor rotor. The engine core assembly includes a core flowpath, a compressor section, a combustor section and a turbine section. The core flowpath extends through the compressor section, the combustor section and the turbine section from an inlet into the core flowpath to an exhaust from the core flowpath. The bypass flowpath bypasses the engine core assembly. The condenser is configured to exchange heat energy between combustion products flowing within the core flowpath downstream of the combustor section and bypass air flowing within the bypass flowpath.

Abstract: A medical system that includes a handle, a shaft extending distally from the handle, and a cap assembly coupled to the distal end of the shaft. The shaft includes one or more channels extending between the handle and a distal end of the shaft, and the cap assembly includes an opening that is configured to expose the one or more channels at the distal end of the shaft. The cap assembly includes a chamber that extends distally from the opening. The medical system includes a porous body movably disposed within the chamber. The porous body is configured to transition from a compressed configuration when disposed inside the chamber to an expanded configuration upon extending outwardly from the chamber.

Abstract: An engine system includes an engine core assembly, a fuel system and a cooling circuit. The engine core assembly includes a core flowpath, a compressor section, a combustor section and a turbine section. The combustor section includes a combustor adjacent a plenum. The fuel system includes a fuel flowpath, a fuel reservoir, a fuel-cooling air heat exchanger and a fuel injector. The fuel flowpath is configured to direct hydrogen fuel, received from the fuel reservoir, through the fuel-cooling air heat exchanger to the fuel injector. The fuel injector is configured to introduce the hydrogen fuel into the combustor. The cooling circuit is configured to direct cooling air, bled from the plenum, through the fuel-cooling air heat exchanger to the turbine section. The fuel-cooling air heat exchanger is configured to exchange heat energy between the hydrogen fuel flowing within the fuel flowpath and the cooling air flowing within the cooling circuit.