Abstract: A system and method of modeling a circulatory system including a regulatory mechanism parameter. In one embodiment, a regulatory mechanism parameter in a lumped parameter model is represented as a logistic function. In another embodiment, the circulatory system model includes a compliant vessel, the model having a parameter representing a change in pressure due to contraction of smooth muscles of a wall of the vessel.

Abstract: A whole-body mathematical model (10) for simulating intracranial pressure dynamics. In one embodiment, model (10) includes 17 interacting compartments, of which nine lie entirely outside of intracranial vault (14). Compartments (F) and (T) are defined to distinguish ventricular from extraventricular CSF. The vasculature of the intracranial system within cranial vault (14) is also subdivided into five compartments (A, C, P, V, and S, respectively) representing the intracranial arteries, capillaries, choroid plexus, veins, and venous sinus. The body's extracranial systemic vasculature is divided into six compartments (I, J, O, Z, D, and X, respectively) representing the arteries, capillaries, and veins of the central body and the lower body. Compartments (G) and (B) include tissue and the associated interstitial fluid in the intracranial and lower regions.

Abstract: A whole-body mathematical model (10) for simulating intracranial pressure dynamics. In one embodiment, model (10) includes 17 interacting compartments, of which nine lie entirely outside of intracranial vault (14). Compartments (F) and (T) are defined to distinguish ventricular from extraventricular CSF. The vasculature of the intracranial system within cranial vault (14) is also subdivided into five compartments (A, C, P, V, and S, respectively) representing the intracranial arteries, capillaries, choroid plexus, veins, and venous sinus. The body's extracranial systemic vasculature is divided into six compartments (I, J, O, Z, D, and X, respectively) representing the arteries, capillaries, and veins of the central body and the lower body. Compartments (G) and (B) include tissue and the associated interstitial fluid in the intracranial and lower regions.

Abstract: A data processing system is provided which can be connected to an existing ply matching and verification system for multiple-part printed products to perform a number of additional operations external to the matching and verification system. The data processing system is configured to access the data stream generated by the matching and verification system at two data points corresponding, respectively, to after indicia on a ply is detected and before it is stored for matching purposes, and after the indicia on all of the plies of a printed product has been stored in a buffer.

Abstract: A method and apparatus for producing a folded document, such as a mailer, including a camera and microprocessor for viewing printed information on a printed sheet and storing the information in a memory. The printed sheet is then folded to enclose the printed information within the folded sheet. A printer is connected to the camera and microprocessor to retrieve the stored information and print the information on the folded sheet.

Abstract: An automatic verification or matching system is provided for insuring that a multiple-part printed product, such as a multiple-ply form with matching variable indicia on each ply, has been properly assembled. The system operates in conjunction with a conventional pin band collator and comprises a plurality of indicia sensing devices, such as bar code scanners and/or video cameras, located at the collator stations for sensing the variable indicia on each part of the product during assembly. Advantages of the system include the ability to use either bar code scanners or video cameras as indicia sensing devices, provision for automatic resequencing of the printers used for printing the variable indicia in the event of a mismatch error, automatic indication of the collator station where a mismatch error has occurred, and automatic marking of defective products that are produced after an error occurs.

Abstract: A signature equipped publication which has bound in to the interior thereof a personalized envelope assembly having at least one disc insert.

Abstract: A signature equipped publication which has bound into the interior thereof a personalized envelope assembly having at least one insert.

Abstract: A signature equipped publication which has bound in to the interior thereof a personalized envelope assembly having at least one insert.

Abstract: A method for selectively binding pre-personalized inserts into book type publications such as magazines, newspapers, and catalogs as well as books themselves, the steps of providing batches of pre-personalized inserts and other inserts, providing a binding line equipped with a selective binding control system, providing a sequential feed for pre-personalized inserts to the binding line along with a diverter and introducer for other inserts into specific books.

Abstract: A multiple site drug iontophoresis electronic device configured for controlling infusion of ionic drugs into a patient through a plurality of electrode pairs. The device includes a plurality of electrode driver channels wherein each driver channel includes an electrode output configured for electrical connection to at least one of the plurality of electrode pairs through lead wires. Each driver channel is electrically isolated from the other driver channels and includes an independent current sink which controls current intensity through the electrode output. A common controller operates the driver channels as a function of treatment parameters supplied by the patient.