Abstract: A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1? and 0.132?; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005? and 0.02? at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.

Abstract: Provided is a photoactivating device (100) for deployment in a washing machine for activating one or more photoactive components in a laundry treatment composition, comprising: a light source (160) configured for emission of light for activation of the one or more photoactive components; a controller (180), and a switch and/or a motion sensing unit (170), wherein the controller (180) is configured to control the light source (160) responsive to the switch and/or signals received from the motion sensing unit (170).

Abstract: An ultrasound transducer sheath includes a first portion comprising a first flexible material. The first portion forms a cylinder defining a passage between a first end and an opposite second end of the first portion. A second portion comprising a second flexible material is coupled to the first end of the first portion. The second portion forms an impermeable planar layer having an exterior surface and an opposing interior surface. An adhesive layer is formed on the interior surface of the impermeable planar layer. The adhesive layer is configured to provide an acoustic coupling interface between an ultrasound transducer and a patient.

Abstract: An ultrasound transducer sheath includes a first portion comprising a first flexible material. The first portion forms a cylinder defining a passage between a first end and an opposite second end of the first portion. A second portion comprising a second flexible material is coupled to the first end of the first portion. The second portion forms an impermeable planar layer having an exterior surface and an opposing interior surface. A first hydrophilic coating layer is formed on the exterior surface of the impermeable planar layer. The first hydrophilic coating layer is activatable to provide an acoustic coupling interface between an ultrasound transducer and a patient.

Abstract: A disposable ultrasound transducer interface pad configured to adhere to at least one of an operational portion of an ultrasound transducer or a skin surface of a patient, includes an impermeable substrate layer having a first surface and a second surface opposite the first surface. A first hydrophilic coating layer is applied to the first surface of the impermeable substrate layer. The first hydrophilic coating layer is activatable to provide an acoustic coupling interface between the ultrasound transducer and the patient. An adhesive layer is formed on the second surface of the impermeable substrate layer and configured to adhere to the operational portion of the ultrasound transducer or the skin surface of the patient.

Abstract: A method of making a disposable ultrasound transducer interface pad includes forming a flexible, impermeable substrate layer having a first side and an opposing second side; applying a first hydrophilic material to the first side of the impermeable substrate layer to form a first hydrophilic layer, wherein the first hydrophilic material is configured to be activatable to provide an acoustic coupling between a patient and an ultrasound transducer; and curing the first hydrophilic layer to form a continuous first hydrophilic layer on the first surface of the impermeable substrate layer.

Abstract: In one embodiment, a method includes receiving first Light Detection and Ranging (LiDAR) data associated with a railroad environment, extracting an asset from the first LiDAR data associated with the railroad environment, and superimposing the asset into a spatial model. The method also includes receiving a field indication associated with a modification to the railroad environment and modifying the spatial model in response to receiving the field indication associated with the modification to the railroad environment. The method further includes receiving second LiDAR data associated with the railroad environment and comparing the second LiDAR data to the modified spatial model.

Abstract: A cover for an ultrasound scanning assembly is provided, wherein the cover exerts compressive force on the patient during use. The cover includes an outer frame and a nonporous or porous film extending across the outer frame. The outer frame is formed of a soft touch material.

Abstract: In one embodiment, a method includes receiving first Light Detection and Ranging (LiDAR) data associated with a railroad environment, extracting an asset from the first LiDAR data associated with the railroad environment, and superimposing the asset into a spatial model. The method also includes receiving a field indication associated with a modification to the railroad environment and modifying the spatial model in response to receiving the field indication associated with the modification to the railroad environment. The method further includes receiving second LiDAR data associated with the railroad environment and comparing the second LiDAR data to the modified spatial model.

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1).

Abstract: Personal care compositions comprising a polymer and a trisolvent system, and the use of the compositions in removing oily soils (such as grease or sebum).

Abstract: In one embodiment, a method includes receiving first Light Detection and Ranging (LiDAR) data associated with a railroad environment, extracting an asset from the first LiDAR data associated with the railroad environment, and superimposing the asset into a spatial model. The method also includes receiving a field indication associated with a modification to the railroad environment and modifying the spatial model in response to receiving the field indication associated with the modification to the railroad environment. The method further includes receiving second LiDAR data associated with the railroad environment and comparing the second LiDAR data to the modified spatial model.

Abstract: In one embodiment, a method includes receiving first Light Detection and Ranging (LiDAR) data associated with a railroad environment, extracting an asset from the first LiDAR data associated with the railroad environment, and superimposing the asset into a spatial model. The method also includes receiving a field indication associated with a modification to the railroad environment and modifying the spatial model in response to receiving the field indication associated with the modification to the railroad environment. The method further includes receiving second LiDAR data associated with the railroad environment and comparing the second LiDAR data to the modified spatial model.

Abstract: In one embodiment, a method includes receiving first Light Detection and Ranging (LiDAR) data associated with a railroad environment, extracting an asset from the first LiDAR data associated with the railroad environment, and superimposing the asset into a spatial model. The method also includes receiving a field indication associated with a modification to the railroad environment and modifying the spatial model in response to receiving the field indication associated with the modification to the railroad environment. The method further includes receiving second LiDAR data associated with the railroad environment and comparing the second LiDAR data to the modified spatial model.

Abstract: Provided is a photoactivating device (100) for deployment in a washing machine for activating one or more photoactive components in a laundry treatment composition, comprising: a light source (160) configured for emission of light for activation of the one or more photoactive components; a controller (180), and a switch and/or a motion sensing unit (170), wherein the controller (180) is configured to control the light source (160) responsive to the switch and/or signals received from the motion sensing unit (170).

Abstract: An immobilizer tool set includes a plurality of retention blocks. Each retention block of the plurality of retention blocks includes a first plate, a guide pin extending from the first plate, and a second plate on the guide pin and configured to slide on the guide pin relative the first plate. A spring is between the first plate and the second plate.

Abstract: The need for a fast acting and broad spectrum antimicrobial composition which does not reduce surface shine and does not leave visible residues on the surface, while also providing greater residuality of the actives can be met by formulating antimicrobial compositions as described herein.