Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: A panel system includes a chassis holding one or more tray arrangements, which are each configured to receive one or more cassettes at two or more bays. The tray arrangements and cassettes cooperate to define a cassette sensor arrangement and a port occupancy sensor arrangement having separate interface points. The cassette sensor arrangement may include electronic memory storing physical layer information about the cassette. All active components of the port occupancy sensor arrangement are disposed on the tray while the electronic memories of the cassette sensor arrangement are stored on the cassettes.

Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: An articulating tire valve install-removal tool and related methods for use. The articulating tire valve install-removal tool has a body comprising an outer perimeter, an inner recess, a threaded member, a linkage, and a contact member. The articulating tire valve install-removal tool components are connected to each other and secured within the body so one or more components can rotate around one or more axes. Together these components facilitate in the valve being installed and removed perpendicular or generally perpendicular to the valve hole on the wheel. The articulating tire valve stem tool includes a linkage assembly that is attached to the body to facilitate in ensuring the valve is installed and removed with the valve perpendicular to the valve hole in the wheel rim.

Abstract: The invention generally relates to optical fibers, and, more particularly, to hollow-core optical fibers and cables for use in high-speed data transmission, including transmission of telecommunications data, and methods of manufacturing such hollow-core optical fibers and cables.

Abstract: In an aspect, a system for carrier selection is presented. A system includes a computing device. A computing device is configured to receive a transport request from an external computing device. A transport request includes transport parameters conveyed to a computing device. A computing device is configured to receive at least a carrier datum from a carrier database. At least a carrier datum corresponds to at least a carrier of a plurality of carriers. A computing device is configured to identify a carrier of a plurality of carriers as a function of a transport request and at least a carrier datum. A computing device is configured to generate a carrier optimization model as a function of a transport request. A computing device is configured to provide a carrier selection as a function of a carrier optimization model and an identified carrier.

Abstract: A pharmaceutical container holder for holding pharmaceutical containers includes a receiver having an interior sized and shaped to receive and hold the pharmaceutical containers as a stack of pharmaceutical containers. The receiver has a removal location from which the pharmaceutical containers are removed from the receiver. A lift raises the pharmaceutical containers disposed in the interior of the receiver upward to move the pharmaceutical containers toward the removal location. A lift controller operates the lift to move the pharmaceutical containers upward toward the removal location after an upper-most pharmaceutical container of the stack of pharmaceutical containers has been removed from the removal location to move a subsequent upper-most pharmaceutical container of the stack of pharmaceutical containers to the removal location.

Abstract: The invention generally relates to optical fibers, and, more particularly, to hollow-core optical fibers and cables for use in high-speed data transmission, including transmission of telecommunications data, and methods of manufacturing such hollow-core optical fibers and cables.

Abstract: An apparatus for mounting and securing medical/surgical devices may be attached to a litter (40), The medical/surgical devices may include. for example, IV holders (186), aspirators (144). cardiac monitors (148) , defibrillators (150) , infusion pumps 152 (152), ventilators (146) and other devices. The apparatus frame assembly (10) includes rails (12), (14), (16), (18), (20), (46), (48), (50), (52) having cross-sections of standard surgical rails, for attachment of slidable rail clamps (84), (104). Medical device mounts (108), (110), (112) are attached to the slidable rail clamps. The medical device mounts have height and/or rotational adjustment to improve patient access and view. The apparatus may be mounted longitudinally anywhere along the litter to maximize access to the patient.

Abstract: The present disclosure relates to AM-14 pharmaceutical formulations and therapeutic dosing regimens for the treatment of disease.

Abstract: Methods, systems, and devices for analyzing communication messages (e.g., emails or activities) to determine relationship strength using a distributed graph are described. In some systems, a user may be associated with a specific tenant. A database server of the system may receive communication messages associated with the user and a target user. The server may perform a natural language processing (NLP) analysis on the communication messages to extract metadata, and may generate or update a distributed graph indicating connections between users based on the extracted metadata. Using the connections of the graph, the server may calculate a closeness score between the user and the target user. Additionally, the server may calculate closeness scores between the target and other users associated with the tenant, and may determine the users with the greatest closeness scores. The server may send a suggestion for the determined users to initiate communication with the target.

Abstract: In an aspect, a system for carrier selection is presented. A system includes a computing device. A computing device is configured to receive a transport request from an external computing device. A transport request includes transport parameters conveyed to a computing device. A computing device is configured to receive at least a carrier datum from a carrier database. At least a carrier datum corresponds to at least a carrier of a plurality of carriers. A computing device is configured to identify a carrier of a plurality of carriers as a function of a transport request and at least a carrier datum. A computing device is configured to generate a carrier optimization model as a function of a transport request. A computing device is configured to provide a carrier selection as a function of a carrier optimization model and an identified carrier.

Abstract: An engine is disclosed having a water cooling system allowing efficient cooling of the exhaust valves to prevent temperature gradients from building in the engine. Water is therefore pumped through the engine though first and second water cooling cores which discharge through the head. A water manifold is positioned over the discharge opening and includes couplings for the radiator supply, radiator return, water pump supply, oil cooler supply and oil cooler return. The engine has separate chambers to isolate the pistons and cylinders, and reed valves cover the chambers and allow the blow-by gases and oil to enter the oil pan during the power stroke of the engine cycle.

Abstract: In an aspect, a system for transport verification is disclosed. A system includes a computing device. A computing device is configured to receive at least a carrier datum from a carrier device. A computing device is configured to verify at least a carrier datum as a function of a transport plan. A computing device is configured to update at least a carrier datum as a function of a verification of a transport plan. A computing device is configured to display an updated at least a carrier datum through a carrier device.

Abstract: An apparatus for mounting and securing medical/surgical devices may be attached to a litter 40. The medical/surgical devices may include, for example, IV holders 186, aspirators 144, cardiac monitors 148, defibrillators 150, infusion pumps 152, ventilators 146 and other devices. The apparatus frame assembly 10 includes rails 12, 14, 16, 18, 20, 46, 48, 50, 52 having cross-sections of standard surgical rails, for attachment of slidable rail clamps 84, 104. Medical device mounts 108, 110, 112 are attached to the slidable rail clamps. The medical device mounts have height and/or rotational adjustment to improve patient access and view. The apparatus may be mounted longitudinally anywhere along the litter to maximize access to the patient.

Abstract: The present disclosure relates to AM-14 pharmaceutical formulations and therapeutic dosing regimens for the treatment of disease.

Abstract: A system for monitoring a transport of a component is disclosed. The system includes a plurality of carriers. A system includes a component transported by a plurality of carriers. A system includes a central identification unit coupled to a component. A system includes a central network. A central network is configured to receive a plurality of component data from a central identification unit. A central network is configured to update a plurality of component data. A central network is configured to update a plurality of carrier data as a function of a plurality of component data. Updating a plurality of carrier data includes modifying each plurality of carrier data as a function of at least an alternate plurality of carrier data. A method for monitoring a transport of a component is also disclosed.

Abstract: The imaging system includes a rotating element that is configured to rotate about a central axis. A plurality of scanners are fixedly attached with the rotating element. Each scanner has a lens that faces generally towards the central axis, and the scanners are spaced apart from one another around the central axis. The scanners are configured to identify an optically readable machine readable code contained on the medication container. An actuator is operably connected with the rotating element and is configured to rotate the rotating element and the scanners around the central axis from respective e first positions to respective second positions to allow the scanners to image different areas of the medication container in response to a failure of the scanners to identify the machine readable code when the scanners were in the respective first positions.

Abstract: In an aspect, a system for carrier identification. A system includes a computing device. A computing device is configured to receive an identification signal from a central identification unit coupled to a carrier of a plurality of carriers. A computing device is configured to identify a carrier of the plurality of carriers via an identification signal. A computing device is configured to arrange a plurality of carriers into a group as a function of a carrier group optimization model. A computing device is configured to receive a carrier datum from a central identification unit. A computing device is configured to update a group of a plurality of carriers as a function of a carrier datum.

Abstract: The imaging system includes a rotating element that is configured to rotate about a central axis. A plurality of scanners are fixedly attached with the rotating element. Each scanner has a lens that faces generally towards the central axis, and the scanners are spaced apart from one another around the central axis. The scanners are configured to identify an optically readable machine readable code contained on the medication container. An actuator is operably connected with the rotating element and is configured to rotate the rotating element and the scanners around the central axis from respective e first positions to respective second positions to allow the scanners to image different areas of the medication container in response to a failure of the scanners to identify the machine readable code when the scanners were in the respective first positions.