Abstract: An impedance based biosensor and method for detecting a target biomolecule in a sample are provided. The biosensor has a substrate, and first and second spaced-apart electrodes disposed at the substrate. A molecular recognition element (MRE) for binding with the target is bound to the substrate between the first and second electrodes. The biosensor also has a nanoparticle having an MRE bound to its surface. In the presence of the target, the nanoparticle is immobilized between the first and second electrodes due to binding of the target biomolecule with the first MRE and binding of the target biomolecule with the second MRE. A measurable change in electrical impedance across the first and second electrodes occurs due to the immobilization of the nanoparticle between the first and second electrodes.

Abstract: The present disclosure relates generally to heterobifunctional linkers.

Abstract: The present disclosure relates generally to heterobifunctional linkers.

Abstract: An impedance based biosensor and method for detecting a target biomolecule in a sample are provided. The biosensor has a substrate, and first and second spaced-apart electrodes disposed at the substrate. A molecular recognition element (MRE) for binding with the target is bound to the substrate between the first and second electrodes. The biosensor also has a nanoparticle having an MRE bound to its surface. In the presence of the target, the nanoparticle is immobilized between the first and second electrodes due to binding of the target biomolecule with the first MRE and binding of the target biomolecule with the second MRE. A measurable change in electrical impedance across the first and second electrodes occurs due to the immobilization of the nanoparticle between the first and second electrodes.

Abstract: A computer-implemented process and apparatus for automatically identifying compounds in a sample mixture. The process involves receiving a a representation of a measured condition of the sample mixture, using the representation of a measured condition of the sample mixture to select a set of reference spectra of compounds suspected to be contained in the sample mixture, from a library of reference spectra, receiving a representation of a test spectrum having peaks associated with compounds therein, the test spectrum being produced from the sample mixture under the measured condition and combining reference spectra from the set of reference spectra to produce a matching composite spectrum having peaks associated with at least some of the suspected compounds, that match peaks in the test spectrum, the compounds associated with the reference spectra that combine to produce the matching spectrum being indicative of the compounds in the sample mixture.

Abstract: A computer implemented process for producing a representation of a reference spectrum for a hypothetical solution having a first pH condition, for use in determining the composition of a test sample, is disclosed, The process involves producing a position value for at least one peak of the reference spectrum in response to a measured pH condition of the test sample and a property of at least one peak in a base reference spectrum for the hypothetical solution, the base reference spectrum being associated with a pH condition of the hypothetical solution that is different from the measured pH condition.

Abstract: A process for quantitative and qualitative analysis for identifying compounds in a sample mixture involves the identification of a set of reference spectra selected according to a measured condition, e.g. pH, of the sample, which collectively define a composite spectrum which best matches a spectrum produced from the sample. The compounds associated with respective reference spectra of the identified set are the compounds that are determined to be likely to be present in the sample. Quantities of the compounds may be determined from the intensities of certain representative peaks associated with the compounds, relative to the intensity of a peak associated with a reference compound which is unaffected by the measured condition of the sample. Thus, given a test spectrum of a sample and given a set of reference spectra, the process can identify and quantify compounds present in the sample.

Abstract: A level apparatus is disclosed that includes a body mounted on an elongate member. The body typically includes a laser that is capable of rotation about horizontal and/or vertical axes. The elongate member can be braced between, for example, a floor and a ceiling and the body is typically capable of longitudinal movement along an axis that is substantially parallel to a longitudinal axis of the elongate member. Movement of the body and other functions of the apparatus can be remote controlled.

Abstract: A level apparatus is disclosed that includes a body mounted on an elongate member. The body typically includes a laser that is capable of rotation about horizontal and/or vertical axes. The elongate member can be braced between, for example, a floor and a ceiling and the body is typically capable of longitudinal movement along an axis that is substantially parallel to a longitudinal axis of the elongate member. Movement of the body and other functions of the apparatus can be remote controlled.

Abstract: A mounting member or connecting device is used to connect a first member to a second member. The connecting device includes a male member and a female member which are coupled together through an opening in the first member. The first member may be a divider panel and the second member may be a cover panel, for example, with the second member having first and second parallel fingers thereon. A tolerance ring, formed in the shape of a band which is less than a complete circle. is mounted on a cylindrical section of the male and female members. The tolerance ring has corrugations thereon which are crushed to some degree when the first and second fingers are pushed on to the associated cylindrical section with the tolerance ring thereon. This connection provides a vibration free connection and also eliminates ESD problems between the connected members.

Abstract: A sheet feeding apparatus includes a retard mechanism to prevent the inadvertent feeding of doubled or overlapped sheets. The retard mechanism includes a plurality of belts in an assembly positioned adjacent to a sheet feeding roller, and rotating in such a direction as to retard the sheets being fed. The retard assembly is mounted on the free end of a lever arm pivotally secured adjacent to its other end to the base of the sheet feeding apparatus. The lever arm with the retard assembly mounted thereon is spring-urged toward the feed roller, but may be moved slightly away from said roller to accommodate the thickness of the sheet being fed between the feed roller and the retard assembly. A dual spring arrangement contained in the lever arm permits the lever arm to move with relatively little force to accommodate passage of a single sheet, but to resist more vigorously any additional movement, such as would be required for the passage of double or overlapped sheets.