Abstract: Formulations for the delivery of therapeutic agents, including chemotherapeutic agents, are provided. In these formulations, a concentrated therapeutic agent and an excipient are configured to be delivered directly by a catheter to a subject in need of therapeutic treatment. Also provided are systems for therapeutic treatment comprising a concentrated therapeutic formulation and a delivery device, where the system is configured for direct delivery of the concentrated formulation by a catheter to a subject in need of therapeutic treatment. Methods of therapeutic treatment comprising delivering a concentrated therapeutic formulation to a subject in need of treatment are also provided, where a concentrated therapeutic agent is delivered directly to the subject by a catheter using a delivery device.