Abstract: A camera system may capture object activity with a field of view comprising one or more regions and identify and selectively output captured image data based on the one or more regions.

Abstract: Mixed virtual and real-world golf systems are provided herein. In one example, a system for implementing a golf game in a mixed virtual and real-world environment is described. The system includes: a field of play upon which the golf game is played, the field of play being divided into: (i) a screen zone, and (ii) a green zone defining a portion of a hole of a golf course; a screen positioned in the screen zone; a projector configured to project a simulation of the hole of the golf course onto a projection surface of the screen; a turntable in the green zone; and a golf green on the turntable, the golf green including: an undulation layer on the turntable; a green surface on the undulation layer; a golf hole cup positioned in a putting region of the green surface; and one or more actuation systems embedded within the undulation layer.

Abstract: Provided herein are bifunctional compounds with a moiety or domain that is a binder of the ubiquitin receptor RPN13 and another moiety or domain that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one domain of the bifunctional compound is a binder of the ubiquitin receptor RPN13 and another domain of the compound is a binder of the target protein DOT1L in a subject.

Abstract: Disclosed herein are compounds of the formulas (A-I) and (B) that may be useful for activating invariant natural killer T (iNKT) cells. According to certain disclosed embodiments activation of iNKT cells induces production of one or more cytokines, such as IFN?, IL-2, IL-4, IL-6 and TNF?, and results in reduction of senescent cells.

Abstract: Disclosed herein are compounds that target SMARCA2 and SMARCA4, causing their degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: The disclosure presents a composite conduit formwork structure which includes a cylindrical outer casing adapted to bond with a cylindrical inner casing which are maintained at a fixed distance apart by a plurality of radial stanchions. The inner casing and outer casing form an interior void which is filled with concrete during manufacture. The outer casing and inner casing remain in place to protect the structure once completed. A novel method of assembly is also provided whereby radial stanchions are rotated between the outer casing and inner casing. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: Provided herein are bifunctional compounds with a moiety or domain that is a binder of the ubiquitin receptor RPN13 and another moiety or domain that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one domain of the bifunctional compound is a binder of the ubiquitin receptor RPN13 and another domain of the compound is a binder of the target protein DOT1L in a subject.

Abstract: Compounds for activating invariant natural killer T cells (iNKT) cells are provided. Compounds according to certain embodiments activate iNKT cells and induce an increase in the production of one or more cytokines, such as IFN?, IL-2, IL-4, IL-6 and TNF?. In some embodiments, activated iNKT cells are used to selectively reduce the presence of or eliminate inflammatory senescent cells, such as senescent cells having an inflammatory secretome (SASP). Methods for activating iNKT cells by contacting an iNKT cell with an amount of the subject compounds and selectively reducing the presence of or eliminating senescent cells with activated iNKT cells are also described. Compositions for practicing the subject methods are also described.

Abstract: A financial institution agnostic saving system including a server configured to (i) receive information for a funding source of a user at a first financial institution; (ii) receive information for a saving account of the user at a second financial institution; (iii) receive user saving target information for the user which includes a saving rule for determining when to transfer funds from the funding source to the saving account wherein the saving rule is defined based on an amount spent by the user; (iv) receive transaction information for a transaction by the user from a third financial institution, wherein the transaction information includes the amount spent by the user; and (v) transfer money from the funding source to the saving account according to the saving rule. The system may include a marketplace which allows users to modify user saving target information and/or make purchases with savings.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for providing a golf simulator comprising a computing system with real-life golf courses stored in memory, a projector, and a screen; projecting a simulation of a real-life golf hole stored in memory on the screen with the computing system to provide a simulated golf hole that simulates the real-life golf hole; and using one or more lights to indicate a location of the ball after a simulation of one or more golf shots.

Abstract: Disclosed is a method of treating cancer with a compound that possesses degradation activity against SMARCA4/2 in combination with a DOT1L r inhibitor.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for providing a golf simulator comprising a computing system with real-life golf courses stored in memory, a projector, and a screen; projecting a simulation of a real-life golf hole stored in memory on the screen with the computing system to provide a simulated golf hole that simulates the real-life golf hole; and using one or more lights to indicate a location of the ball after a simulation of one or more golf shots.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for providing a golf simulator comprising a computing system with real-life golf courses stored in memory, a projector, and a screen; projecting a simulation of a real-life golf hole stored in memory on the screen with the computing system to provide a simulated golf hole that simulates the real-life golf hole; and using one or more lights to indicate a location of the ball after a simulation of one or more golf shots.

Abstract: A camera system may capture object activity with a field of view comprising one or more regions and identify and selectively output captured image data based on the one or more regions.

Abstract: Compounds for activating invariant natural killer T cells (iNKT) cells are provided. Compounds according to certain embodiments activate iNKT cells and induce an increase in the production of one or more cytokines, such as IFN-?, IL-2, IL-4, IL-6 and TNF?. In some embodiments, activated iNKT cells are used to selectively reduce the presence of or eliminate inflammatory senescent cells, such as senescent cells having an inflammatory secretome (SASP). Methods for activating iNKT cells by contacting an iNKT cell with an amount of the subject compounds and selectively reducing the presence of or eliminating senescent cells with activated iNKT cells are also described. Compositions for practicing the subject methods are also described.

Abstract: The disclosure presents a composite concrete structure formwork which comprises stay in place fiberglass profiles and reinforcement to form various building and shelter structures. The structures include an interior container maintained at a set distance within an exterior container to form a void. The void is filled with wet concrete which is allowed to cure. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a composite column formwork which utilizes a fiber reinforced polymer (FRP) stay in place container which incorporates horizontally coplanar support chairs bonded to the interior surface, closed ties bonded to the support chairs and a plurality of longitudinal rebar enforcements bonded to the closed ties. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a composite conduit formwork structure which includes a cylindrical outer casing adapted to bond with a cylindrical inner casing which are maintained at a fixed distance apart by a plurality of radial stanchions. The inner casing and outer casing form an interior void which is filled with concrete during manufacture. The outer casing and inner casing remain in place to protect the structure once completed. A novel method of assembly is also provided whereby radial stanchions are rotated between the outer casing and inner casing. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one component of the bifunctional compound is a binder of an E3 ubiquitin ligase (e.g., lenalidomide, thalidomide) and another component of the compound is a binder of the target protein DOT1L in a subject.

Abstract: The disclosure presents a composite conduit formwork structure which includes a cylindrical outer casing adapted to bond with a cylindrical inner casing which are maintained at a fixed distance apart by a plurality of radial stanchions. The inner casing and outer casing form an interior void which is filled with concrete during manufacture. The outer casing and inner casing remain in place to protect the structure once completed. A novel method of assembly is also provided whereby radial stanchions are rotated between the outer casing and inner casing. All of the components in a preferred embodiment are formed of a fiberglass material.