Abstract: The present disclosure provides a novel amplification method that enables easy detection of a target nucleic acid with high specificity and sensitivity in a closed system, comprising. a biosensor pair that allows determination of amplification of a target sequence by detecting conformational change of the looped primer by using fluor/quencher FRET techniques.

Abstract: A device for securing a cap of a container. The device may include a bottom plate and a top plate. The bottom plate may be formed with a side opening open towards a side of the device to receive in the cap of the container closing an open end of the container, and a center opening connected to the side opening. The center opening may be dimensioned to receive the cap of the container and have a width larger than a width of a portion of the side opening. The side opening and the center opening may define a pair of inward protrusions to capture the cap of the container. The top plate may be spaced away from the bottom plate and configured to at least partially cover the cap of the container.

Abstract: The present disclosure provides a novel loop-de-loop method of detecting a target nucleic acid using a biosensor-labeled oligonucleotide. Further provided herein is a looped primer and a kit for use in the method.

Abstract: The present disclosure provides a novel loop-de-loop method of detecting a target nucleic acid using a biosensor-labeled oligonucleotide. Further provided herein is a looped primer and a kit for use in the method.

Abstract: The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.

Abstract: The present disclosure provides a novel loop-de-loop method of detecting a target nucleic acid using a biosensor-labeled oligonucleotide. Further provided herein is a looped primer and a kit for use in the method.

Abstract: The present invention relates, in part, to systems configured to obtain samples from an organism in an autonomous manner. Such systems can employ a cartridge configured to provide bait to attract an organism, as well as channels to store and/or test samples obtained from the organism.

Abstract: The present disclosure provides a novel loop-de-loop method of detecting a target nucleic acid using a biosensor-labeled oligonucleotide. Further provided herein is a looped primer and a kit for use in the method.

Abstract: The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.

Abstract: The present disclosure provides a novel loop-de-loop method of detecting a target nucleic acid using a biosensor-labeled oligonucleotide. Further provided herein is a looped primer and a kit for use in the method.

Abstract: An assembly for use with a water meter includes: a housing including a meter portion integrally formed with a valve portion; and a valve positioned in the valve portion and in sealable communication with an inner surface of the housing, the valve defining a valve inlet portion and a valve outlet portion, the valve inlet portion defining a vertical portion and separated from the valve outlet portion by a top edge portion defined in the vertical portion, the valve inlet portion sealable from the valve outlet portion by a diaphragm assembly of the valve, the diaphragm assembly defining a water leak passthrough configured to allow passage of water from a first side of the diaphragm assembly to a second side of the diaphragm assembly opposite from the first side.

Abstract: The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.

Abstract: The present invention relates to probes and primers beneficial for conducting amplification assays, such as those including loop-mediated isothermal amplification reactions. Also described herein are methods for detecting targets using such probes and/or primers.

Abstract: An assembly for use with a water meter includes: a housing including a meter portion integrally formed with a valve portion; and a valve positioned in the valve portion and in sealable communication with an inner surface of the housing, the valve defining a valve inlet portion and a valve outlet portion, the valve inlet portion defining a vertical portion and separated from the valve outlet portion by a top edge portion defined in the vertical portion, the valve inlet portion sealable from the valve outlet portion by a diaphragm assembly of the valve, the diaphragm assembly defining a water leak passthrough configured to allow passage of water from a first side of the diaphragm assembly to a second side of the diaphragm assembly opposite from the first side.

Abstract: An assembly for use with a water meter includes: a housing including a meter portion integrally formed with a valve portion; and a valve positioned in the valve portion and in sealable communication with an inner surface of the housing, the valve defining a valve inlet portion and a valve outlet portion, the valve inlet portion defining a vertical portion and separated from the valve outlet portion by a top edge portion defined in the vertical portion, the valve inlet portion sealable from the valve outlet portion by a diaphragm assembly of the valve, the diaphragm assembly defining a water leak passthrough configured to allow passage of water from a first side of the diaphragm assembly to a second side of the diaphragm assembly opposite from the first side.

Abstract: The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.

Abstract: The present invention relates to microfluidic check valves, as well as fluidic cartridges including such check valves. In particular examples, the check valve includes a pre-stressed spring formed from a planar substrate. Various characteristics of the valves, such as size, profile, opening pressure, etc., can be tuned to provide desired performance when employed within a fluidic cartridge.