Abstract: A method for locating electrical activity in a patient comprising the steps of (1) obtaining a sensing patch having a plurality of fiducial markers compatible with an imaging system and a plurality of sensors adapted to collect electrical signals found on a surface of the patient's skin, (2) securing the sensing patch to the patient with a position relative to a heart of the patient, (3) operating the imaging system to obtain an image of the heart of the patient and at least one of the plurality of fiducial markers, and (4) creating an electric field map corresponding the heart of the patient.

Abstract: A patch includes a sensor layer and adhesive disposed along an outer surface of the sensor layer. The sensor layer has a plurality of sensors, each adapted to measure a value of an electric field, and a plurality of magnets wherein each of the plurality of magnets is collocated with one of the plurality of sensors. Electric field data from the plurality of sensors is provided to a cardiac monitor.

Abstract: A patch including a fiducial layer, an adhesive, and a sensor layer. The fiducial layer having a surface adapted to secure to a portion of skin on a patient, wherein the fiducial layer further includes a plurality of fiducial markers having at least one of acoustic properties, material density, and proton content different from those of human tissue. The adhesive being disposed along the surface of the fiducial layer. The sensor layer removably secured to a side of the fiducial layer and positionable distal the skin of the patient. The sensor layer including a plurality of sensors evenly spaced from one another, adapted to be in electrical communication with the skin of the patient, and each adapted to measure at least electric field or impedance.

Abstract: A method of monitoring a health status of a patient using a monitoring system comprising a pair of finger ring electrocardiogram (ECG) monitors. Each finger ring monitor comprises an inner ring member and an outer ring member positioned radially outward from and operably connected to the inner ring member. The inner ring member of each monitor features a conductor characterized by at least one physiological-type sensor, and an annular bladder that defines an adjustable aperture sized to receive a left-hand finger of a patient and a right-hand finger of the patient, respectively. Upon triggering by positioning the pair of finger ring ECG monitors substantially together, the conductors of each of the finger ring ECG monitors are configured to receive biopotential signals from skin on the fingers of the patient.

Abstract: A patch includes a sensor layer and adhesive disposed along an outer surface of the sensor layer. The sensor layer has a plurality of sensors, each adapted to measure a value of an electric field, and a plurality of magnets wherein each of the plurality of magnets is collocated with one of the plurality of sensors. Electric field data from the plurality of sensors is provided to a cardiac monitor.

Abstract: A system for monitoring cardiac health of a user including a local sensing subsystem, a contactless interrogation subsystem, and a remote monitoring subsystem. The local sensing subsystem may include a sensor patch configured to attach to the user and include a substrate, a passive radio-frequency identification transponder, and a first antenna. The contactless interrogation subsystem may include an interrogator separated from the sensor patch, which may include a second antenna, a demodulator, and a communications link. The remote monitoring subsystem may include a computing system comprising a processor for executing instructions. The local sensing subsystem may be adapted to perform at least one scan. The contactless interrogation subsystem may be adapted to operate the demodulator to receive a cardiac event and to operate the communications link to transmit the cardiac event. The remote monitoring subsystem may be adapted to execute the instructions to detect an arrhythmia from the cardiac reading.

Abstract: A system and method for verifying patient identity including a heart monitor, a memory, and a processor. The heart monitor may be adapted to collect a baseline ECG signal from a patient and a monitored ECG signal from the patient. The memory may be in electrical communication with the heart monitor and adapted to store a plurality of baseline statistical characteristics of the baseline ECG signal and a plurality of monitored statistical characteristics of the monitored ECG signal. The processor may be in electrical communication with the memory and adapted to compare the plurality of baseline statistical characteristics to the plurality of monitored statistical characteristics and determine a likelihood of patient match. The heart monitor may be configured for further collection of the monitored ECG signal if the likelihood of patient match is greater than a threshold level.

Abstract: A method of operating a wireless ECG sensor system may include (1) wirelessly transmitting, using a second antenna, electromagnetic radiation having a frequency equal to the resonant frequency of a first antenna of a sensor patch; (2) inductively receiving, using the first antenna, power for operating a passive RFID transponder of the sensor patch; and (3) operating the microcontroller of the sensor patch to perform at least one scan, wherein performing the at least one scan is defined as: (a) receiving a cardiac activity signal from at least one of the positive and negative electrodes of the sensor patch, (b) retrieving a location identifier from the storage medium of the sensor patch, and (c) operating the load modulation switch of the sensor patch to alter a voltage amplitude of the electromagnetic radiation to transmit to a demodulator a cardiac event reading comprising the cardiac activity signal and the location identifier.

Abstract: A wireless ECG sensor system includes a sensor patch configured to attach to a user. The sensor patch may include a substrate having a positive and a negative electrode, and a passive radio-frequency identification (RFID) transponder carried by the substrate. The RFID may include a first antenna, a non-transitory and non-volatile storage medium in electrical communication with the first antenna, a load modulation switch in electrical communication with the first antenna, and a microcontroller in electrical communication with the first antenna and in data communication with both the storage medium and the load modulation switch. The system may also include an interrogator device having a second antenna configured to wirelessly transmit electromagnetic radiation having a resonant frequency of the first antenna of the sensor patch, and a demodulator configured to measure a voltage amplitude of the electromagnetic radiation wirelessly transmitted by the second antenna.

Abstract: A system and method for verifying patient identity including a heart monitor, a memory, and a processor. The heart monitor may be adapted to collect a baseline ECG signal from a patient and a monitored ECG signal from the patient. The memory may be in electrical communication with the heart monitor and adapted to store a plurality of baseline statistical characteristics of the baseline ECG signal and a plurality of monitored statistical characteristics of the monitored ECG signal. The processor may be in electrical communication with the memory and adapted to compare the plurality of baseline statistical characteristics to the plurality of monitored statistical characteristics and determine a likelihood of patient match. The heart monitor may be configured for further collection of the monitored ECG signal if the likelihood of patient match is greater than a threshold level.

Abstract: A patch including a fiducial layer, an adhesive, and a sensor layer. The fiducial layer having a surface adapted to secure to a portion of skin on a patient, wherein the fiducial layer further includes a plurality of fiducial markers having at least one of acoustic properties, material density, and proton content different from those of human tissue. The adhesive being disposed along the surface of the fiducial layer. The sensor layer removably secured to a side of the fiducial layer and positionable distal the skin of the patient. The sensor layer including a plurality of sensors evenly spaced from one another, adapted to be in electrical communication with the skin of the patient, and each adapted to measure at least electric field or impedance.

Abstract: A method of monitoring a health status of a patient using a monitoring system comprising a processor, an electrical signal conversion unit, and a pair of earbud electrocardiogram (ECG) monitors. Each earbud monitor comprises conductive electrode component (e.g., physiological-type sensor) configured to receive biopotential signals from a respective ear of the patient. The electrical signal conversion unit controls earbud operations, and converts earbud readings into ECG data that are transmitted to a smartphone for further analysis. The electrical signal conversion unit components may include a System on a Chip (SoC) comprising a data store, a processor, and a power supply.

Abstract: A system for monitoring cardiac health of a user including a local sensing subsystem, a contactless interrogation subsystem, and a remote monitoring subsystem. The local sensing subsystem may include a sensor patch configured to attach to the user and include a substrate, a passive radio-frequency identification transponder, and a first antenna. The contactless interrogation subsystem may include an interrogator separated from the sensor patch, which may include a second antenna, a demodulator, and a communications link. The remote monitoring subsystem may include a computing system comprising a processor for executing instructions. The local sensing subsystem may be adapted to perform at least one scan. The contactless interrogation subsystem may be adapted to operate the demodulator to receive a cardiac event and to operate the communications link to transmit the cardiac event. The remote monitoring subsystem may be adapted to execute the instructions to detect an arrhythmia from the cardiac reading.

Abstract: A method of operating a wireless ECG sensor system may include (1) wirelessly transmitting, using a second antenna, electromagnetic radiation having a frequency equal to the resonant frequency of a first antenna of a sensor patch; (2) inductively receiving, using the first antenna, power for operating a passive RFID transponder of the sensor patch; and (3) operating the microcontroller of the sensor patch to perform at least one scan, wherein performing the at least one scan is defined as: (a) receiving a cardiac activity signal from at least one of the positive and negative electrodes of the sensor patch, (b) retrieving a location identifier from the storage medium of the sensor patch, and (c) operating the load modulation switch of the sensor patch to alter a voltage amplitude of the electromagnetic radiation to transmit to a demodulator a cardiac event reading comprising the cardiac activity signal and the location identifier.

Abstract: A finger ring health status monitoring device comprising an inner ring member and an outer ring member positioned radially outward from and operably connected to the inner ring member. The inner ring member features a conductor characterized by at least one physiological-type sensor, and an annular bladder that defines an adjustable aperture sized to receive a finger of a patient. Adjustment of the aperture is accomplished by rotating the outer ring member in a first direction about an axis of rotation common to the outer ring member and to the inner ring member, thereby causing the bladder to expand radially inward so as to reduce an inside diameter of the aperture. Rotating the outer ring member in a second direction opposite the first direction causes the bladder to contract, thus increasing the inside diameter of the aperture.

Abstract: A method of monitoring a health status of a patient using a monitoring system comprising a pair of finger ring electrocardiogram (ECG) monitors. Each finger ring monitor comprises an inner ring member and an outer ring member positioned radially outward from and operably connected to the inner ring member. The inner ring member of each monitor features a conductor characterized by at least one physiological-type sensor, and an annular bladder that defines an adjustable aperture sized to receive a left-hand finger of a patient and a right-hand finger of the patient, respectively. Upon triggering by positioning the pair of finger ring ECG monitors substantially together, the conductors of each of the finger ring ECG monitors are configured to receive biopotential signals from skin on the fingers of the patient.

Abstract: A wireless ECG sensor system includes a sensor patch configured to attach to a user. The sensor patch may include a substrate having a positive and a negative electrode, and a passive radio-frequency identification (RFID) transponder carried by the substrate. The RFID may include a first antenna, a non-transitory and non-volatile storage medium in, electrical communication with the first antenna, a load modulation switch in electrical communication with the first antenna, and a microcontroller in electrical communication with the first antenna and in data communication with both the storage medium and the load modulation switch. The system may also include an interrogator device having a second antenna configured to wirelessly transmit electromagnetic radiation having a resonant frequency of the first antenna of the sensor patch, and a demodulator configured to measure a voltage amplitude of the electromagnetic radiation wirelessly transmitted by the second antenna.

Abstract: The disclosure provides methods for inhibiting the activity of a miRNA cluster in a cell, and also for screening a cell for a phenotype(s) of interest resulting from inhibition of a miRNA cluster. The methods use a cluster pool which comprises at least one miRNA inhibitor specific for each miRNA in the miRNA cluster. MiRNA inhibitors are described that induce apoptosis in breast cancer cells and hence are useful in the treatment of breast cancer. The disclosure also provides pharmaceutical compositions which are useful for the treatment of breast cancer; methods for inducing the nuclear translocation of NF-?B in a breast cancer cell; methods for inducing the nuclear translocation of c-Jun in a breast cancer cell; method for inhibiting the nuclear translocation of NF-?B in a breast cancer cell; and methods for providing prognostic medical information relating to breast cancer progression.

Abstract: Disclosed herein are a collection of miRNAs and genes whose expression is altered in hypertrophic cardiomyopathy. Accordingly, these miRNAs and genes, singly or in combination, are useful as molecular markers for diagnosis or prognosis of hypertrophic cardiomyopathy. The miRNAs and genes disclosed can also be therapeutic targets for cardiac hypertrophy. For example, agents such as miRNA mimics, miRNA inhibitors or siRNAs for a given miRNA or gene can be used to modulate the level of these molecules thereby inhibiting or preventing hypertrophic cardiomyopathy.

Abstract: The disclosure provides methods for inhibiting the activity of a miRNA cluster in a cell, and also for screening a cell for a phenotype(s) of interest resulting from inhibition of a miRNA cluster. The methods use a cluster pool which comprises at least one miRNA inhibitor specific for each miRNA in the miRNA cluster. MiRNA inhibitors are described that induce apoptosis in breast cancer cells and hence are useful in the treatment of breast cancer. The disclosure also provides pharmaceutical compositions which are useful for the treatment of breast cancer; methods for inducing the nuclear translocation of NF-?B in a breast cancer cell; methods for inducing the nuclear translocation of c-Jun in a breast cancer cell; method for inhibiting the nuclear translocation of NF-?B in a breast cancer cell; and methods for providing prognostic medical information relating to breast cancer progression.