Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.

Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.

Abstract: A method for locating electrical activity in a patient comprising the steps of (1) obtaining a sensing patch having a plurality of fiducial markers compatible with an imaging system and a plurality of sensors adapted to collect electrical signals found on a surface of the patient's skin, (2) securing the sensing patch to the patient with a position relative to a heart of the patient, (3) operating the imaging system to obtain an image of the heart of the patient and at least one of the plurality of fiducial markers, and (4) creating an electric field map corresponding the heart of the patient.

Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.

Abstract: A patch includes a sensor layer and adhesive disposed along an outer surface of the sensor layer. The sensor layer has a plurality of sensors, each adapted to measure a value of an electric field, and a plurality of magnets wherein each of the plurality of magnets is collocated with one of the plurality of sensors. Electric field data from the plurality of sensors is provided to a cardiac monitor.

Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.

Abstract: A patch including a fiducial layer, an adhesive, and a sensor layer. The fiducial layer having a surface adapted to secure to a portion of skin on a patient, wherein the fiducial layer further includes a plurality of fiducial markers having at least one of acoustic properties, material density, and proton content different from those of human tissue. The adhesive being disposed along the surface of the fiducial layer. The sensor layer removably secured to a side of the fiducial layer and positionable distal the skin of the patient. The sensor layer including a plurality of sensors evenly spaced from one another, adapted to be in electrical communication with the skin of the patient, and each adapted to measure at least electric field or impedance.

Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.

Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.

Abstract: A method of monitoring a health status of a patient using a monitoring system comprising a pair of finger ring electrocardiogram (ECG) monitors. Each finger ring monitor comprises an inner ring member and an outer ring member positioned radially outward from and operably connected to the inner ring member. The inner ring member of each monitor features a conductor characterized by at least one physiological-type sensor, and an annular bladder that defines an adjustable aperture sized to receive a left-hand finger of a patient and a right-hand finger of the patient, respectively. Upon triggering by positioning the pair of finger ring ECG monitors substantially together, the conductors of each of the finger ring ECG monitors are configured to receive biopotential signals from skin on the fingers of the patient.

Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.

Abstract: A patch includes a sensor layer and adhesive disposed along an outer surface of the sensor layer. The sensor layer has a plurality of sensors, each adapted to measure a value of an electric field, and a plurality of magnets wherein each of the plurality of magnets is collocated with one of the plurality of sensors. Electric field data from the plurality of sensors is provided to a cardiac monitor.

Abstract: A system and method for verifying patient identity including a heart monitor, a memory, and a processor. The heart monitor may be adapted to collect a baseline ECG signal from a patient and a monitored ECG signal from the patient. The memory may be in electrical communication with the heart monitor and adapted to store a plurality of baseline statistical characteristics of the baseline ECG signal and a plurality of monitored statistical characteristics of the monitored ECG signal. The processor may be in electrical communication with the memory and adapted to compare the plurality of baseline statistical characteristics to the plurality of monitored statistical characteristics and determine a likelihood of patient match. The heart monitor may be configured for further collection of the monitored ECG signal if the likelihood of patient match is greater than a threshold level.

Abstract: A system for monitoring cardiac health of a user including a local sensing subsystem, a contactless interrogation subsystem, and a remote monitoring subsystem. The local sensing subsystem may include a sensor patch configured to attach to the user and include a substrate, a passive radio-frequency identification transponder, and a first antenna. The contactless interrogation subsystem may include an interrogator separated from the sensor patch, which may include a second antenna, a demodulator, and a communications link. The remote monitoring subsystem may include a computing system comprising a processor for executing instructions. The local sensing subsystem may be adapted to perform at least one scan. The contactless interrogation subsystem may be adapted to operate the demodulator to receive a cardiac event and to operate the communications link to transmit the cardiac event. The remote monitoring subsystem may be adapted to execute the instructions to detect an arrhythmia from the cardiac reading.

Abstract: A method of operating a wireless ECG sensor system may include (1) wirelessly transmitting, using a second antenna, electromagnetic radiation having a frequency equal to the resonant frequency of a first antenna of a sensor patch; (2) inductively receiving, using the first antenna, power for operating a passive RFID transponder of the sensor patch; and (3) operating the microcontroller of the sensor patch to perform at least one scan, wherein performing the at least one scan is defined as: (a) receiving a cardiac activity signal from at least one of the positive and negative electrodes of the sensor patch, (b) retrieving a location identifier from the storage medium of the sensor patch, and (c) operating the load modulation switch of the sensor patch to alter a voltage amplitude of the electromagnetic radiation to transmit to a demodulator a cardiac event reading comprising the cardiac activity signal and the location identifier.

Abstract: A wireless ECG sensor system includes a sensor patch configured to attach to a user. The sensor patch may include a substrate having a positive and a negative electrode, and a passive radio-frequency identification (RFID) transponder carried by the substrate. The RFID may include a first antenna, a non-transitory and non-volatile storage medium in electrical communication with the first antenna, a load modulation switch in electrical communication with the first antenna, and a microcontroller in electrical communication with the first antenna and in data communication with both the storage medium and the load modulation switch. The system may also include an interrogator device having a second antenna configured to wirelessly transmit electromagnetic radiation having a resonant frequency of the first antenna of the sensor patch, and a demodulator configured to measure a voltage amplitude of the electromagnetic radiation wirelessly transmitted by the second antenna.

Abstract: A system and method for verifying patient identity including a heart monitor, a memory, and a processor. The heart monitor may be adapted to collect a baseline ECG signal from a patient and a monitored ECG signal from the patient. The memory may be in electrical communication with the heart monitor and adapted to store a plurality of baseline statistical characteristics of the baseline ECG signal and a plurality of monitored statistical characteristics of the monitored ECG signal. The processor may be in electrical communication with the memory and adapted to compare the plurality of baseline statistical characteristics to the plurality of monitored statistical characteristics and determine a likelihood of patient match. The heart monitor may be configured for further collection of the monitored ECG signal if the likelihood of patient match is greater than a threshold level.

Abstract: A patch including a fiducial layer, an adhesive, and a sensor layer. The fiducial layer having a surface adapted to secure to a portion of skin on a patient, wherein the fiducial layer further includes a plurality of fiducial markers having at least one of acoustic properties, material density, and proton content different from those of human tissue. The adhesive being disposed along the surface of the fiducial layer. The sensor layer removably secured to a side of the fiducial layer and positionable distal the skin of the patient. The sensor layer including a plurality of sensors evenly spaced from one another, adapted to be in electrical communication with the skin of the patient, and each adapted to measure at least electric field or impedance.

Abstract: A method of monitoring a health status of a patient using a monitoring system comprising a processor, an electrical signal conversion unit, and a pair of earbud electrocardiogram (ECG) monitors. Each earbud monitor comprises conductive electrode component (e.g., physiological-type sensor) configured to receive biopotential signals from a respective ear of the patient. The electrical signal conversion unit controls earbud operations, and converts earbud readings into ECG data that are transmitted to a smartphone for further analysis. The electrical signal conversion unit components may include a System on a Chip (SoC) comprising a data store, a processor, and a power supply.

Abstract: A method of operating a wireless ECG sensor system may include (1) wirelessly transmitting, using a second antenna, electromagnetic radiation having a frequency equal to the resonant frequency of a first antenna of a sensor patch; (2) inductively receiving, using the first antenna, power for operating a passive RFID transponder of the sensor patch; and (3) operating the microcontroller of the sensor patch to perform at least one scan, wherein performing the at least one scan is defined as: (a) receiving a cardiac activity signal from at least one of the positive and negative electrodes of the sensor patch, (b) retrieving a location identifier from the storage medium of the sensor patch, and (c) operating the load modulation switch of the sensor patch to alter a voltage amplitude of the electromagnetic radiation to transmit to a demodulator a cardiac event reading comprising the cardiac activity signal and the location identifier.