Patents by Inventor Scott Benson
Scott Benson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140114048Abstract: Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths, to quench a broader range of reporter emission wavelengths than previously possible, or can combine both concepts. Multiple types of quenching moieties can be employed to increase the absorption range and a multiple number of each type of quenching moiety can be used to increase the total absorptivity within the absorption range. The multi-chromophoric quenchers can be tethered to probes for biomolecules, insoluble supports and/or fluorescent dyes for use in a wide variety of biomolecular assays.Type: ApplicationFiled: October 15, 2013Publication date: April 24, 2014Applicant: Applied Biosystems, LLCInventors: Scott BENSON, Steven MENCHEN, Krishna UPADHYA
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Patent number: 8412569Abstract: A system determines a number of times that clients access a group of documents associated with a web site or a group of web sites. At least one document in the group of documents includes at least one advertisement. The system further determines a percentage of client views for an advertiser or an advertising network across the web site or group of web sites based on the determined number of times.Type: GrantFiled: February 4, 2011Date of Patent: April 2, 2013Assignee: Google Inc.Inventors: Scott Benson, Gokul Rajaram
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Publication number: 20110206578Abstract: Methods for activating and/or reactivating a metal oxide surface for deposition, immobilizing, and/or growing a biological sample (e.g., an oligonucleotide, a polynucleotide, functionalized particle, a polymer, etc.) thereon are disclosed. The metal oxide surface (e.g., zirconium oxide) can be activated and/or reactivated by exposing the metal oxide surface to various activation and/or treatment protocols capable of enhancing a slide's activity relative to the activity of an untreated slide. The activation and/or treatment protocol can include subjecting the slide (or at least the metal oxide layer) to an oxygen plasma treatment and/or a peroxide solution for an amount of time sufficient to activate and/or reactivate the metal oxide surface. Activated sequencing slides capable of incorporation, for example, into various embodiments of a flow cell for use in NGS platforms are also disclosed herein.Type: ApplicationFiled: February 23, 2011Publication date: August 25, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Evan Foster, Jessica Reed, Heather Shepherd, Christina Inman, Scott Benson
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Publication number: 20080071070Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.Type: ApplicationFiled: April 2, 2007Publication date: March 20, 2008Applicant: Applera CorporationInventors: Scott Benson, Ruiming Zou, Krishna Upadhya, Paul Kenney, Jonathan Cassel
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Patent number: 7343898Abstract: An engine includes a stationary member, a crankshaft supported for rotation by the stationary member, and a flywheel rotatable in response to rotation of the crankshaft. A fan has a plurality of fins and is rotatable in response to movement of the flywheel. A movable air vane includes a surface that deflects air from the fins as the fins move with the flywheel. The engine also includes an intake passageway for intake air and a throttle lever including a throttle pivot point and a throttle linkage aperture. The throttle linkage aperture and the throttle pivot point define a first axis having a first side and a second side. A throttle valve is disposed in the intake passageway to control the flow of intake air. The throttle valve is movable in response to movement of the throttle lever. A throttle linkage is positioned to directly or indirectly connect the air vane and the throttle lever. The throttle linkage and the movable air vane are disposed on the first side of the first axis.Type: GrantFiled: February 13, 2007Date of Patent: March 18, 2008Assignee: Briggs & Stratton CorporationInventors: Ricky Caldwell, Jason Walker, Daron Wilson, Scott Benson
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Publication number: 20070239532Abstract: A system determines a number of times that clients access a group of documents associated with a web site or a group of web sites. At least one document in the group of documents includes at least one advertisement. The system further determines a percentage of client views for an advertiser or an advertising network across the web site or group of web sites based on the determined number of times.Type: ApplicationFiled: March 31, 2006Publication date: October 11, 2007Inventors: Scott Benson, Gokul Rajaram
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Publication number: 20070099210Abstract: Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.Type: ApplicationFiled: August 21, 2006Publication date: May 3, 2007Applicant: Applera CorporationInventors: Scott Benson, Joe Lam, Steven Menchen
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Publication number: 20060167257Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.Type: ApplicationFiled: September 16, 2005Publication date: July 27, 2006Applicant: Applera CorporationInventors: Ronald Graham, Ruiming Zou, Krishna Upadhya, Scott Benson
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Publication number: 20060063186Abstract: Dark quencher constructs, termed “multi-chromophoric quenchers” are described herein that comprise at least two dark quenching moieties, which can be the same or different, linked together by at least one multivalent linking moiety. The structure of the multi-chromophoric quenchers can be varied to selectively enhance quenching within a specific range of reporter emission wavelengths. This can be accomplished by linking together, into a single molecule, two or more identical quenchers, by reacting the quenchers with a multivalent linker. The structure of the multi-chromophoric quencher can also be varied to quench a broader range of reporter emission wavelengths than previously possible. This can be accomplished by linking together, into a single molecule, two or more different quenchers, by reacting the quenchers with a multivalent linker.Type: ApplicationFiled: September 14, 2005Publication date: March 23, 2006Applicant: Applera CorporationInventors: Scott Benson, Steven Menchen, Krishna Upadhya
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Publication number: 20060051791Abstract: Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.Type: ApplicationFiled: July 7, 2005Publication date: March 9, 2006Applicant: Applera CorporationInventors: Scott Benson, Joel Lam, Steven Menchen
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Publication number: 20050112781Abstract: A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R1-R6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group, or, when taken together, R1 and R6 is benzo, or, when taken together, R4 and R5 is benzo; R7-R10, R12-R16 and R18 may be hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, amido, nitrile, lower alkoxy, linking group; R11 and R17 may be hydrogen, lower alkyl, lower alkene, lower alkyne, phenyl, aryl, linking group; Y1-Y4 are hydrogen, lower alkyl, or cycloalkyl, or, when taken together, Y1 and R2, Y2 and R1 Y3 and R3, and/or Y4 and R4 is propano, ethano, or substituted forms thereof, and X1-X3 taken separately are hydrogen, chlorine, fluorine, lower alkyl, carboxylate, sulfonate, hydroxymethyl, and linking group, or any combinations thereof.Type: ApplicationFiled: February 26, 2004Publication date: May 26, 2005Inventors: Linda Lee, Scott Benson, Barnett Rosenblum, Sandra Spurgeon, Ronald Graham
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Publication number: 20050107617Abstract: The present invention provides a novel class of fluorescent cyanine dye compounds that are modified at one of the hetercyclic ring nitrogen atoms with a mobility-modifying moiety that permits the electrophoretic mobilities of polynucleotides labeled with the mobility-modifying cyanine dyes to be adjusted or tuned in a predictable fashion while retaining enzymatic activity. The ability to predictably tune the relative electrophoretic mobilities of the dyes permits the creation of sets of mobility-matched fluorescent dyes of a variety of structures for a variety of applications, including fluorescence-based 4-color nucleic acid sequencing reactions.Type: ApplicationFiled: March 15, 2004Publication date: May 19, 2005Applicant: Applera CorporationInventors: Steven Menchen, Scott Benson, Barnett Rosenblum, Shaheer Khan
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Publication number: 20050027130Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.Type: ApplicationFiled: August 24, 2004Publication date: February 3, 2005Applicant: Applera CorporationInventors: Joe Lam, Scott Benson, Steven Menchen
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Patent number: 6754647Abstract: Method and apparatus are disclosed for the development and implementation of virtual robot's (bot's) directed natural language interaction with computer users. Bots employing the present invention base natural language interaction on a predefined universe of discourse that is decomposed hierarchically into domains. A data structure provides a storage area for each domain. The data structure may reflect the hierarchical decomposition. Domain topics containing program code directing the bot's interaction are placed in domain storage areas. Pattern lists associate words expected to be “heard” by the bot with particular domain topics. Domain topics are provided, as appropriate, to direct a user's attention toward the instant domain's parent, siblings, or children, with lower topics in the hierarchy getting higher preference. Domain censoring and domain tiebreakers improve usability.Type: GrantFiled: September 26, 2000Date of Patent: June 22, 2004Assignee: Verity, Inc.Inventors: Walter Tackett, John B. Hodges, Scott Benson, D. Patrick Blair, Kate Boynton, Ray Dillinger, Martin Eggenberger, Tom Schofield