Abstract: A free motion valve system is disclosed. The free motion valve system includes (a) a base platform configured to be attached to a lower opening of a firefighting bucket, the platform having at least one open area configured to allow water to enter and exit the bucket; and (b) a valve assembly including a plate structure configured to move between a closed position in which the plate structure covers the open area and an open position in which water can move through the opening, the valve assembly being configured so that the plate structure moves freely toward the open position in response to upward pressure against a lower surface of the plate structure. Methods of using the free motion valve system with firefighting buckets are also disclosed.

Abstract: The specification relates to compounds of Formula (A) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: Aerial fire-fighting bucket systems are disclosed for liquid cargo pickup, transport, and discharge. Bucket systems include a valve system disposed in the lower structure and a computer-controlled hydraulic motor/pump and accumulator configured to maintain hydraulic pressure, and controls to release liquid cargo from the bucket by a hydraulically activated valve assembly. Hydraulic accumulator charging operates independently of activation of cargo pickup, transport, and discharge cycles. Hydraulic accumulator sizing provides for a minimum of actuations of extension and retraction of the piston within a short-time interval reducing weight and electrical supply burdens on the aircraft.

Abstract: The specification relates to compounds of Formula (A) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

Abstract: Embodiments of the invention allow a player to have a unique gaming experience, different than other players, even when playing on the same network. A game may span several gaming sessions. States of a game, for example a bonus game, may be stored when the player decides to stop playing the game. When the player initiates a next gaming session, at the same or another location, the previous state of the game is re-loaded onto the gaming machine and the player returns to the previous state. Further, additional bonuses can be implemented because the network knows the identity and other information about the player. The additional bonuses may be unique to that player. Messages particular to a player are exchanged between a gaming device and a gaming network.

Abstract: Embodiments of the invention allow a player to have a unique gaming experience, different than other players, even when playing on the same network. A game may span several gaming sessions. States of a game, for example a bonus game, may be stored when the player decides to stop playing the game. When the player initiates a next gaming session, at the same or another location, the previous state of the game is re-loaded onto the gaming machine and the player returns to the previous state. Further, additional bonuses can be implemented because the network knows the identity and other information about the player. The additional bonuses may be unique to that player. Messages particular to a player are exchanged between a gaming device and a gaming network.

Abstract: Embodiments of the invention allow a player to have a unique gaming experience, different than other players, even when playing on the same network. A game may span several gaming sessions. States of a game, for example a bonus game, may be stored when the player decides to stop playing the game. When the player initiates a next gaming session, at the same or another location, the previous state of the game is re-loaded onto the gaming machine and the player returns to the previous state. Further, additional bonuses can be implemented because the network knows the identity and other information about the player. The additional bonuses may be unique to that player. Messages particular to a player are exchanged between a gaming device and a gaming network.

Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

Abstract: Embodiments of the invention allow a player to have a unique gaming experience, different than other players, even when playing on the same network. A game may span several gaming sessions. States of a game, for example a bonus game, may be stored when the player decides to stop playing the game. When the player initiates a next gaming session, at the same or another location, the previous state of the game is re-loaded onto the gaming machine and the player returns to the previous state. Further, additional bonuses can be implemented because the network knows the identity and other information about the player. The additional bonuses may be unique to that player. Messages particular to a player are exchanged between a gaming device and a gaming network.

Abstract: The present invention provides novel methods and devices for providing audio to players of a gaming machine and to nearby players. According to preferred implementations, sounds intended for a person currently using a gaming machine are distinguished from second sounds intended for persons who are not currently using the gaming machine. The former sounds are directed to the player of the gaming machine by one or more methods and/or devices. For example, the gaming machine may include a device for producing ultrasonic waves (e.g., in a beam) that produce the first sounds via interaction with a medium, a sound dome, a speaker array, or other devices for producing directional sound. The sound may be directed to a predetermined area near the gaming machine. Alternatively, the sound may be directed to an area at or near where the player is detected to be, where the player's player tracking card is detected to be, etc.

Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: Embodiments of the invention allow a player to have a unique gaming experience, different than other players, even when playing on the same network. A game may span several gaming sessions. States of a game, for example a bonus game, may be stored when the player decides to stop playing the game. When the player initiates a next gaming session, at the same or another location, the previous state of the game is re-loaded onto the gaming machine and the player returns to the previous state. Further, additional bonuses can be implemented because the network knows the identity and other information about the player. The additional bonuses may be unique to that player. Messages particular to a player are exchanged between a gaming device and a gaming network.

Abstract: A gaming table assembly for a table game configured to deliver a bonus game to a player at the gaming table. The assembly including a gaming table, a dealer station for a gaming dealer, and a plurality of player stations for one or more players. At least one interactive display terminal is included associated with the gaming table that is dedicated to one or more of the plurality of player stations. The display terminal is configured to display content selected from the group consisting of a bonus game, an advertisement, player tracking information, news and bonus awards.

Abstract: A method and apparatus for operating networked gaming devices to display a calendar image within a promotions display on a gaming machine. The method includes configuring a promotion at a configuration workstation coupled over a network to a plurality of gaming devices. Players are permitted to play one of the gaming devices with each of said gaming device having a touch screen display. A calendar graphic is displayed within the touch screen display having of a plurality of day boxes, with the promotion associated with and displayed within one of the day boxes. Information about the promotion is communicated to the player via the touch screen display associated with the gaming device. The method and apparatus accepts a communication from the player via the touch screen display indicative of a player selection of the promotion displayed in one of the day boxes, and implements the promotion responsive to the selection.