Patents by Inventor Scott Breining

Scott Breining has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110118239
    Abstract: A novel scalable synthesis for the preparation of 7-(3-pyridinyI)-1,7-diazaspiro[4.4)nonane has been developed, and 7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane salts have been formed with succinic acid and oxalic acid. Additionally, 7-(3-pyridinyl)-1,7-diaza-spiro[4.4]nonane has been separated into its stereoisomers via resolution with L and D di-p-toluoyltartaric acids, giving (R)- and (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane of high enantiomeric purity. Numerous solid salts of the resulting (R)- and (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4}nonane have been prepared. Methods for the preparation of the racemic and enantiomeric salts, pharmaceutical compositions comprising such salts, and uses thereof are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.
    Type: Application
    Filed: January 15, 2009
    Publication date: May 19, 2011
    Applicant: Targacept, Inc.
    Inventors: Jessica Beaver, Scott Breining, Gary Maurice Dull, Gregory J. Gatto, John Genus, Jacob Mathew, Julio A. Munoz, Inigo Pfeiffer, Steve M. Ttoler, James Wamsley, Jianxun Xie
  • Publication number: 20080085888
    Abstract: The present invention provides a combination of (a) an antipsychotic and (b) an alpha4/beta2 (?4?2)-neuronal nicotinic receptor agonist. The invention further relates to pharmaceutical compositions comprising said combination and to the use of the combination in therapy. The invention further relates to a kit comprising the combination and use of said kit in therapy.
    Type: Application
    Filed: September 14, 2007
    Publication date: April 10, 2008
    Inventors: Scott Breining, John Evenden, Edwin Johnson, Kristen Jordan, Sharon Letchworth, Craig Miller, Ladislav Mrzljak, James Wamsley, Dan Widzowski, Yun-De Xiao
  • Publication number: 20060074067
    Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds, prodrugs or metabolites of these compounds, or pharmaceutically acceptable salts thereof. The aryl group can be a phenyl ring or a five- or six-membered heterocyclic ring (heteroaryl). The compounds and compositions can be used to treat and/or prevent a wide variety of conditions or disorders, particularly those disorders characterized by dysfunction of nicotinic cholinergic neurotransmission, including disorders involving neuromodulation of neurotransmitter release, such as dopamine release. CNS disorders, which are characterized by an alteration in normal neurotransmitter release, are another example of disorders that can be treated and/or prevented. The compounds and compositions can also be used to alleviate pain.
    Type: Application
    Filed: September 19, 2005
    Publication date: April 6, 2006
    Inventors: Balwinder Bhatti, Scott Breining, Philip Hammond, Jozef Klucik, Yun-De Xiao
  • Publication number: 20050282823
    Abstract: Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a compound of Formulas 1 or 2, as described herein. The compounds of Formulas 1 and 2 are also useful for treating pain, and treating drug addiction, nicotine addiction, and/or obesity. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.
    Type: Application
    Filed: October 15, 2004
    Publication date: December 22, 2005
    Applicant: TARGACEPT, INC.
    Inventors: Scott Breining, Balwinder Bhatti, Gregory Hawkins, Lan Miao, Anatoly Mazurov, Teresa Phillips, Craig Miller