Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Some embodiments of the disclosure include disclosed compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the disclosed compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the disclosed IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: An airbag compartment enclosure assembly is disclosed, including a compartment containing an uninflated airbag and a closure device fixed proximate an opening of the compartment. The closure device has an open position allowing expansion of the airbag through the opening and a closed position retaining the uninflated airbag. The closure device includes a first flap extending from a first edge of the opening and a second flap extending from a second, opposing edge of the opening. The first and second flaps are folded over one another in the closed position.

Abstract: An airbag compartment enclosure assembly is disclosed, including a compartment containing an uninflated airbag and a closure device fixed proximate an opening of the compartment. The closure device has an open position allowing expansion of the airbag through the opening and a closed position retaining the uninflated airbag. The closure device includes a first flap extending from a first edge of the opening and a second flap extending from a second, opposing edge of the opening. The first and second flaps are folded over one another in the closed position.

Abstract: An airbag compartment enclosure assembly is disclosed, including a compartment containing an uninflated airbag and a closure device fixed proximate an opening of the compartment. The closure device has an open position allowing expansion of the airbag through the opening and a closed position retaining the uninflated airbag. The closure device includes a first flap extending from a first edge of the opening and a second flap extending from a second, opposing edge of the opening. The first and second flaps are folded over one another in the closed position.

Abstract: An airbag compartment enclosure assembly is disclosed, including a compartment containing an uninflated airbag and a closure device fixed proximate an opening of the compartment. The closure device has an open position allowing expansion of the airbag through the opening and a closed position retaining the uninflated airbag. The closure device includes a first flap extending from a first edge of the opening and a second flap extending from a second, opposing edge of the opening. The first and second flaps are folded over one another in the closed position.

Abstract: A system for identifying the location of a dipole magnetic field source below ground. The system comprises a first receiver assembly and a second receiver assembly each configured to detect the dipole magnetic field in three dimensions from a transmitter and generate antenna signals indicative of the detected dipole magnetic field. The first receiver assembly detects the dipole magnetic field from the transmitter substantially simultaneously as the second receiver assembly simultaneously detects the dipole magnetic field from the transmitter. The second receiver assembly is movable relative to both the first receiver assembly and the transmitter. A processor determines the location of the transmitter below ground based on the antenna signals generated by the first and second receiver assemblies.

Abstract: Described herein are compounds and methods of using nitric oxide (NO) generating compositions with a phosphodiesterase inhibitor of a phosphodiesterase that hydrolyzes cyclic guanosine monophosphate (cGMP) to improve the efficacy and decrease the side effects of these inhibitors.

Abstract: A receiver system for identifying a location of a magnetic field source using at least two tri-axial antennas. The two tri-axial antennas are laterally displaced from one another and may also be held in a substantially horizontal plane. Each of the tri-axial antennas detects a dipole magnetic field from the magnetic field source in three dimension. The receiver system uses a processor to receive an antenna signal from each of the two tri-axial antennas to determine the location of the magnetic field source using the antenna signals.

Abstract: A method for noise signal analysis and communication with an underground transmitter. The method comprises the steps of measuring a noise floor when no signal is transmitted from a transmitter, detecting a signal when the transmitter is transmitting, and estimating the noise free component of the signal by removing the noise floor measurement. The measurement of the noise floor and detecting the signal from the transmitter may be done using a root mean square technique. The noise floor measurement can be removed from the measured signal by subtracting the noise floor measurement from the measured signal or alternatively by calculating the square root of the difference between the square of the measured signal and the square of the noise floor measurement. The noise estimation technique may be used in connection with a differential phased shift keying communication scheme or other modulation techniques.

Abstract: A method and receiver system for identifying a location of a magnetic field source using two horizontally displaced tri-axial antennas. In a preferred embodiment two tri-axial antennas are positioned at opposite ends of a receiver frame. Each antenna detects in three dimensions a magnetic field from a source or transmitter. The receiver is maintained in a horizontal plane and the receiver is moved in the horizontal plane until a flux angle measured at each of the two points is zero so that the receiver is in the vertical plane perpendicular to the axis of the source. The depth and location of the source in three dimensions relative to the receiver is determined using the detected field values. The receiver is moved in a direction defined by a line containing the two points of the receiver until a magnitude of the magnetic field detected at each of the two points is substantially the same so that the receiver is positioned above the source.

Abstract: A method and receiver system for identifying a location of a magnetic field source using two horizontally displaced tri-axial antennas. In a preferred embodiment two tri-axial antennas are positioned at opposite ends of a receiver frame. Each antenna detects in three dimensions a magnetic field from a source or transmitter. The receiver is maintained in a horizontal plane and the receiver is moved in the horizontal plane until a flux angle measured at each of the two points is zero so that the receiver is in the vertical plane perpendicular to the axis of the source. The depth and location of the source in three dimensions relative to the receiver is determined using the detected field values. The receiver is moved in a direction defined by a line containing the two points of the receiver until a magnitude of the magnetic field detected at each of the two points is substantially the same so that the receiver is positioned above the source.

Abstract: A method for guiding a downhole tool assembly using a receiver system. The receiver system comprises two antenna assemblies disposed in a substantially horizontal plane. The antenna assemblies are set at a target point such that the two antenna assemblies each lie on a desired borepath. The two antenna assemblies simultaneously detect in three dimensions a magnetic field source transmitted from the downhole tool assembly to determine a position of the downhole tool assembly.

Abstract: Compositions comprising from about 40 weight parts to about 1000 weight parts of a botanical nitrate source; from about 20 weight parts to about 500 weight parts of a botanical source of nitrite reduction activity; and from about 4 weight parts to about 100 weight parts of a nitrite salt. Methods of reducing triglycerides or reducing C-reactive protein levels are also provided.

Abstract: Compositions comprising a nitrite salt, a nitrate salt, and ascorbic acid are provided in several embodiments. Use of said composition in a method of enhancing cardiovascular performance or treating adverse cardiovascular event in a mammal is also provided.

Abstract: A combustion liner stop block having insertable wear features and methods for installing wear features within a combustion liner stop block are disclosed. The methods may generally include enlarging a slot defined in the liner stop block to form a cavity, locating an insert block in the cavity and providing at least one wear feature associated with the insert block.

Abstract: A method for noise signal analysis and communication with an underground transmitter. The method comprises the steps of measuring a noise floor when no signal is transmitted from a transmitter, detecting a signal when the transmitter is transmitting, and estimating the noise free component of the signal by removing the noise floor measurement. The measurement of the noise floor and detecting the signal from the transmitter may be done using a root mean square technique. The noise floor measurement can be removed from the measured signal by subtracting the noise floor measurement from the measured signal or alternatively by calculating the square root of the difference between the square of the measured signal and the square of the noise floor measurement. The noise estimation technique may be used in connection with a differential phased shift keying communication scheme or other modulation techniques.

Abstract: A method and receiver system for identifying a location of a magnetic field source using two horizontally displaced tri-axial antennas. In a preferred embodiment two tri-axial antennas are positioned at opposite ends of a receiver frame. Each antenna detects in three dimensions a magnetic field from a source or transmitter. The receiver is maintained in a horizontal plane and the receiver is moved in the horizontal plane until a flux angle measured at each of the two points is zero so that the receiver is in the vertical plane perpendicular to the axis of the source. The depth and location of the source in three dimensions relative to the receiver is determined using the detected field values. The receiver is moved in a direction defined by a line containing the two points of the receiver until a magnitude of the magnetic field detected at each of the two points is substantially the same so that the receiver is positioned above the source.

Abstract: A method for noise signal analysis and communication with an underground transmitter. The method comprises the steps of measuring a noise floor when no signal is transmitted from a transmitter, detecting a signal when the transmitter is transmitting, and estimating the noise free component of the signal by removing the noise floor measurement. The measurement of the noise floor and detecting the signal from the transmitter may be done using a root mean square technique. The noise floor measurement can be removed from the measured signal by subtracting the noise floor measurement from the measured signal or alternatively by calculating the square root of the difference between the square of the measured signal and the square of the noise floor measurement. The noise estimation technique may be used in connection with, a differential phased shift keying communication scheme or other modulation techniques.