Patents by Inventor Scott Buttram
Scott Buttram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6093383Abstract: This invention relates to bisamine bisthiol radiolabel binding moieties and synthetic methods therefor. Specifically, the invention provides radiolabel binding moieties that form an electrically neutral complex with technetium-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 25, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 6086849Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: February 9, 1995Date of Patent: July 11, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 6074627Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety covalently attached to a specific binding peptide via an amino acid side-chain of the peptide.Type: GrantFiled: May 14, 1996Date of Patent: June 13, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 6017510Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.Type: GrantFiled: June 27, 1994Date of Patent: January 25, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Robert S. Lees, Scott Buttram
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Patent number: 5997844Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety covalently attached to a specific binding peptide via an amino acid side-chain of the peptide.Type: GrantFiled: June 3, 1994Date of Patent: December 7, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5989519Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.Type: GrantFiled: October 11, 1994Date of Patent: November 23, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Robert S. Lees, Scott Buttram, John Lister-James
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Patent number: 5965107Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: April 20, 1992Date of Patent: October 12, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5922303Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 13, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5866097Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.Type: GrantFiled: October 28, 1994Date of Patent: February 2, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, William McBride, Scott Buttram
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Patent number: 5814297Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.Type: GrantFiled: June 6, 1995Date of Patent: September 29, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, William McBride, Scott Buttram
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Patent number: 5807537Abstract: The invention elates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.Type: GrantFiled: June 5, 1995Date of Patent: September 15, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, William McBride, Scott Buttram
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Patent number: 5807538Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: September 15, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Robert S. Lees, Scott Buttram
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Patent number: 5780007Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 14, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5776428Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 7, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5720934Abstract: This invention relates to radiolabel binding moieties for producing radiolabeled peptides and methods for making such peptides. Specifically, the invention relates to picolinic acid or picolinamine containing radiolabel binding moieties, peptides radiolabeled therewith and methods of making and using both the radiolabel binding moieties and peptides radiolabeled therewith.Type: GrantFiled: June 6, 1995Date of Patent: February 24, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5711931Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to technetium-99m (Tc-99m) labeled leukocyte-binding peptides, methods and kits for making such peptides, and methods for using such peptides to image sites of infection and inflammation in a mammalian body.Type: GrantFiled: June 7, 1995Date of Patent: January 27, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram
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Patent number: 5648471Abstract: A one vial method for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is disclosed. The method comprises contacting an antibody mixture comprised of a sulfhydryl containing antibody or antibody fragment and a reducing agent with technetium-99m in an oxidized state. In a preferred embodiment, the antibody mixture further contains a water soluble ligand. A one vial kit for labeling a sulfhydryl containing antibody or antibody fragment with technetium-99m is also disclosed.Type: GrantFiled: March 7, 1991Date of Patent: July 15, 1997Assignee: Centocor, Inc.Inventors: Scott Buttram, Richard T. Dean, John Lister-James, Koon Yan Pak
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Patent number: 5443815Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.Type: GrantFiled: November 27, 1991Date of Patent: August 22, 1995Assignee: Diatech, Inc.Inventors: Richard T. Dean, William McBride, Scott Buttram
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Patent number: 5405597Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention specifically provides somatostatin, somatostatin derivatives, somatostatin analogues or peptides that bind to the somatostatin receptor and contain at least 2 cysteine residues that form a disulfide or wherein the disulfide is reduced to the sulfhydryl form that are labeled with technetium-99m and that can be targeted to specific sites within a mammalian body for imaging.Type: GrantFiled: November 17, 1992Date of Patent: April 11, 1995Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James, Scott Buttram
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Patent number: 5225180Abstract: The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention specifically provides somatostatin, somatostatin derivatives, somatostatin analogues or peptides that bind to the somatostatin receptor and contain at least 2 cysteine residues that form a disulfide or wherein the disulfide is reduced to the sulfhydryl form that are directly labeled with technetium-99m and that can be targeted to specific sites within a mammalian body for imaging.Type: GrantFiled: September 10, 1991Date of Patent: July 6, 1993Assignee: Diatech, Inc.Inventors: Richard T. Dean, John Lister-James, Scott Buttram