Patents by Inventor Scott C. Benson

Scott C. Benson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190119732
    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 25, 2019
    Applicant: Life Technologies Corporation
    Inventors: Scott C. Benson, Cinna Monighetti, Sandy M. Koepf
  • Publication number: 20190091648
    Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.
    Type: Application
    Filed: November 30, 2018
    Publication date: March 28, 2019
    Inventors: Alexander MASTROIANNI, Scott C. BENSON, Steven M. MENCHEN, John SCOTT
  • Patent number: 10143990
    Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: December 4, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Alexander Mastroianni, Scott C. Benson, Steven M. Menchen, John Scott
  • Patent number: 10131936
    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 20, 2018
    Assignee: Life Technologies Corporation
    Inventors: Scott C. Benson, Cinna Monighetti, Sandy M. Koepf
  • Publication number: 20180127811
    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
    Type: Application
    Filed: September 18, 2017
    Publication date: May 10, 2018
    Applicant: Life Technologies Corporation
    Inventors: Scott C. Benson, Cinna Monighetti, Sandy M. Koepf
  • Publication number: 20180057516
    Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
    Type: Application
    Filed: September 1, 2017
    Publication date: March 1, 2018
    Applicant: Applied Biosystems, LLC
    Inventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
  • Patent number: 9852919
    Abstract: A method of manufacturing a sensor, the method including forming an array of chemically-sensitive field effect transistors (chemFETs), depositing a dielectric layer over the chemFETs in the array, depositing a protective layer over the dielectric layer, etching the dielectric layer and the protective layer to form cavities corresponding to sensing surfaces of the chemFETs, and removing the protective layer. The method further includes, etching the dielectric layer and the protective layer together to form cavities corresponding to sensing surfaces of the chemFETs. The protective layer is at least one of a polymer, photoresist material, noble metal, copper oxide, and zinc oxide. The protective protective layer is removed using at least one of sodium hydroxide, organic solvent, aqua regia, ammonium carbonate, hydrochloric acid, acetic acid, and phosphoric acid.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: December 26, 2017
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Christina E. Inman, Alexander Mastroianni, Wolfgang Hinz, Shifeng Li, Scott C. Benson
  • Patent number: 9790544
    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: October 17, 2017
    Assignee: Life Technologies Corporation
    Inventors: Scott C. Benson, Cinna Monighetti, Sandy M. Koepf
  • Patent number: 9783560
    Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 10, 2017
    Assignee: Applied Biosystems, LLC
    Inventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel
  • Patent number: 9551029
    Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 24, 2017
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
  • Publication number: 20170007977
    Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.
    Type: Application
    Filed: July 6, 2016
    Publication date: January 12, 2017
    Inventors: Alexander MASTROIANNI, Scott C. BENSON, Steven M. MENCHEN, John SCOTT
  • Patent number: 9493656
    Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: November 15, 2016
    Assignee: Life Technologies Corporation
    Inventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson
  • Publication number: 20160258004
    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 8, 2016
    Inventors: Scott C. Benson, Cinna Monighetti, Sandy M. Koepf
  • Publication number: 20160122813
    Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.
    Type: Application
    Filed: October 30, 2015
    Publication date: May 5, 2016
    Inventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
  • Patent number: 9315859
    Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: April 19, 2016
    Assignee: Life Technologies Corporation
    Inventors: Scott C. Benson, Cinna Monighetti, Sandy M. Koepf
  • Patent number: 9309561
    Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: April 12, 2016
    Assignee: Applied Biosystems, LLC
    Inventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
  • Publication number: 20150274975
    Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.
    Type: Application
    Filed: June 16, 2015
    Publication date: October 1, 2015
    Inventors: Joe Y.L. LAM, Steven M. MENCHEN, Ruiming ZOU, Scott C. BENSON
  • Publication number: 20150232494
    Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Inventors: Scott C. BENSON, Ruiming N. ZOU, Krishna G. UPADHYA, Paul M. KENNEY, Jonathan M. CASSEL
  • Publication number: 20150206762
    Abstract: A method of manufacturing a sensor, the method including forming an array of chemically-sensitive field effect transistors (chemFETs), depositing a dielectric layer over the chemFETs in the array, depositing a protective layer over the dielectric layer, etching the dielectric layer and the protective layer to form cavities corresponding to sensing surfaces of the chemFETs, and removing the protective layer. The method further includes, etching the dielectric layer and the protective layer together to form cavities corresponding to sensing surfaces of the chemFETs. The protective layer is at least one of a polymer, photoresist material, noble metal, copper oxide, and zinc oxide. The protective protective layer is removed using at least one of sodium hydroxide, organic solvent, aqua regia, ammonium carbonate, hydrochloric acid, acetic acid, and phosphoric acid.
    Type: Application
    Filed: April 1, 2015
    Publication date: July 23, 2015
    Inventors: Christina E. INMAN, Alexander MASTROIANNI, Wolfgang HINZ, Shifeng LI, Scott C. BENSON
  • Patent number: 9040674
    Abstract: The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: May 26, 2015
    Assignee: Applied Biosystems, LLC
    Inventors: Scott C. Benson, Ruiming N. Zou, Krishna G. Upadhya, Paul M. Kenney, Jonathan M. Cassel