Patents by Inventor Scott C. Fahrenkrug
Scott C. Fahrenkrug has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240057570Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: ApplicationFiled: September 19, 2022Publication date: February 22, 2024Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 11477969Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: GrantFiled: September 20, 2018Date of Patent: October 25, 2022Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20220056482Abstract: The present disclosure relates to methods for making genetic edits in vitro in a non-human vertebrate cell or embryo at a plurality of target chromosomal DNA sites. Methods for making a non-human animal having multiplex genetic edits at a plurality of target chromosomal DNA sites and making a non-human vertebrate animal chimeric for host cells and donor cells are also considered.Type: ApplicationFiled: July 19, 2021Publication date: February 24, 2022Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20210185990Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: ApplicationFiled: December 10, 2020Publication date: June 24, 2021Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10959414Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: GrantFiled: November 2, 2017Date of Patent: March 30, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10959415Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: GrantFiled: September 11, 2019Date of Patent: March 30, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10920242Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: GrantFiled: May 28, 2019Date of Patent: February 16, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Patent number: 10893667Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: GrantFiled: September 11, 2019Date of Patent: January 19, 2021Assignee: Recombinetics, Inc.Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20200017878Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: ApplicationFiled: September 11, 2019Publication date: January 16, 2020Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20200017882Abstract: Human or humanized tissues and organs suitable for transplant are disclosed herein. Gene editing of a host animal provides a niche for complementation of the missing genetic information by donor stem cells. Editing of a host genome to knock out or disrupt genes responsible for the growth and/or differentiation of a target organ and injecting that animal at an embryo stage with donor stem cells to complement the missing genetic information for the growth and development of the organ. The result is a chimeric animal in which the complemented tissue (human/humanized organ) matches the genotype and phenotype of the donor. Such organs may be made in a single generation and the stem cell may be taken or generated from the patient's own body. As disclosed herein, it is possible to do so by simultaneously editing multiple genes in a cell or embryo creating a “niche” for the complemented tissue.Type: ApplicationFiled: April 16, 2019Publication date: January 16, 2020Inventors: Scott C. Fahrenkrug, Laurence Cooper, Perry B. Hackett, Daniel F. Carlson
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Publication number: 20200017877Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: ApplicationFiled: September 11, 2019Publication date: January 16, 2020Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20190335725Abstract: A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis, wherein the disruption of the target gene prevents formation of functional gametes of the animal. Animals that create progeny with donor genetics, and methods of making and using the same. Cells, and methods of making and using the cells, with a genetic modification to disrupt a target gene selectively involved in gametogenesis.Type: ApplicationFiled: June 3, 2019Publication date: November 7, 2019Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20190323031Abstract: Methods, uses, and compositions for manipulating genomic DNA. Some of the embodiments of the invention provide for making a founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as TALENs or CRISPR with a preferred truncation. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell (optionally with a mismatch in the binding of the targeting endonuclease and the targeted site). Another embodiment includes processes of making a genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the animal from becoming sexually mature.Type: ApplicationFiled: May 28, 2019Publication date: October 24, 2019Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20190254266Abstract: Human or humanized tissues and organs suitable for transplant are disclosed herein. Gene editing of a host animal provides a niche for complementation of the missing genetic information by donor stem cells. Editing of a host genome to knock out or debilitate genes responsible for the growth and/or differentiation of a target organ and injecting that animal at an embryo stage with donor stem cells to complement the missing genetic information for the growth and development of the organ. The result is a chimeric animal in which the complemented tissue (human/humanized organ) matches the genotype and phenotype of the donor. Such organs may be made in a single generation and the stem cell may be taken or generated from the patient's own body. As disclosed herein, it is possible to do so by simultaneously editing multiple genes in a cell or embryo creating a “niche” for the complemented tissue.Type: ApplicationFiled: October 27, 2016Publication date: August 22, 2019Applicants: Regents of the University of Minnesota, Recombinetics, Inc., Board of Regents of the University of Texas SystemInventors: Scott C. Fahrenkrug, Daniel F. Carlson, Peter Igarashi, Thomas Carroll
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Publication number: 20190223417Abstract: Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin receptor (PRLR) gene. When expressed, the livestock animals produce a PRLR that is missing up to the terminal 148 amino acid (aa) residues of the protein all ranges and values within the explicitly stated range are contemplated: e.g., from 148 to 69. Animals expressing SLICK have superior thermoregulatory ability compared to non-slick animals and experience a less drastic depression in milk yield during the summer.Type: ApplicationFiled: February 21, 2019Publication date: July 25, 2019Inventors: Tad S. Sonstegard, Daniel F. Carlson, Scott C. Fahrenkrug
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Publication number: 20190194687Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: ApplicationFiled: March 6, 2019Publication date: June 27, 2019Inventors: Scott C. Fahrenkrug, Daniel F. Carlson, Tad S. Sonstegard
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Publication number: 20190106708Abstract: Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.Type: ApplicationFiled: September 20, 2018Publication date: April 11, 2019Inventors: Scott C. Fahrenkrug, Daniel F. Carlson
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Publication number: 20180310536Abstract: A genetically modified livestock animal comprising a genomic modification to an eIF4G gene. Cells, genes, and proteins encompassing a protease-resistant eIF4G protein or gene.Type: ApplicationFiled: July 13, 2018Publication date: November 1, 2018Inventors: Daniel F. Carlson, Scott C. Fahrenkrug
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Patent number: 10058078Abstract: A genetically modified livestock animal comprising a genomic modification to an eIF4G gene. Cells, genes, and proteins encompassing a protease-resistant eIF4G protein or gene.Type: GrantFiled: March 15, 2013Date of Patent: August 28, 2018Assignee: RECOMBINETICS, INC.Inventors: Daniel F. Carlson, Scott C. Fahrenkrug
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Publication number: 20180235194Abstract: Materials and methods for making multiplex gene edits in cells and are presented. Further methods include animals and methods of making the same. Methods of making chimeric animals are presented, as well as chimeric animals.Type: ApplicationFiled: March 16, 2018Publication date: August 23, 2018Inventors: Scott C. Fahrenkrug, Daniel F. Carlson