Patents by Inventor Scott C. Virgil

Scott C. Virgil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUATERNARY HETEROATOM CONTAINING COMPOUNDS
    Publication number: 20230098847
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Application
    Filed: July 18, 2022
    Publication date: March 30, 2023
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Quaternary heteroatom containing compounds
    Patent number: 11390585
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: July 19, 2022
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • CDK INHIBITORS AND USES THEREOF
    Publication number: 20220106325
    Abstract: The present disclosure provides compounds and compositions that are CDK inhibitors selective for CDK4 and/or CDK6, and methods of use thereof.
    Type: Application
    Filed: July 26, 2019
    Publication date: April 7, 2022
    Inventors: Brendan M. O'Boyle, Justin A. Hilf, Scott C. Virgil, Alexander W. Sun, Brian M. Stoltz, Dylan Conklin, Martina S. McDermott, Neil A. O'Brien, Michael J. Palazzolo, Dennis Slamon, Michael D. Bartberger
  • METHOD FOR SEPARATION OF METHIONINE SULFOXIDE DIASTEREOMERS
    Publication number: 20210230110
    Abstract: A method of separating a compound having methionine oxide diastereomers, including: loading a diastereomeric mixture into a chromatography column, the diastereomeric mixture of a compound having a plurality of methionine oxide diastereoisomers. The method also includes passing a mobile phase, the mobile phase including a supercritical fluid, through the chromatography column to separate the compound based on each methionine oxide diastereoisomer of the plurality of methionine oxide diastereoisomers in the chromatography column.
    Type: Application
    Filed: January 22, 2021
    Publication date: July 29, 2021
    Inventors: Jevgenij Raskatov, Scott C. Virgil
  • QUATERNARY HETEROATOM CONTAINING COMPOUNDS
    Publication number: 20210155592
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 27, 2021
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Quaternary heteroatom containing compounds
    Patent number: 10906875
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: February 2, 2021
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Methods for preparing bis-tetrahydroisoquinoline-containing compounds
    Patent number: 10781213
    Abstract: (?)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: September 22, 2020
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Eric R. Welin, Scott C. Virgil, Pamela Tadross, Gerit M. Pototschnig, Aurapat (Fa) Ngamnithiporn, Kenji Negoro, Guillaume Lapointe, Max Klatte, Christopher Haley, Christian Gruenanger, Emil Glibstrup, Christopher Gilmore, Kevin McCormack Allan
  • Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
    Patent number: 10745354
    Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic ?-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: August 18, 2020
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Aurapat Ngamnithiporn, Carina I. Jette, Shoshana Bachman, Scott C. Virgil, Sebastian Lackner
  • Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds
    Publication number: 20200157102
    Abstract: (?)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.
    Type: Application
    Filed: November 22, 2019
    Publication date: May 21, 2020
    Inventors: Brian M. Stoltz, Eric R. Welin, Scott C. Virgil, Pamela Tadross, Gerit M. Pototschnig, Aurapat (Fa) Ngamnithiporn, Kenji Negoro, Guillaume Lapointe, Max Klatte, Christopher Haley, Christian Gruenanger, Emil Glibstrup, Christopher Gilmore, Kevin McCormack Allan
  • QUATERNARY HETEROATOM CONTAINING COMPOUNDS
    Publication number: 20200157049
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Application
    Filed: May 31, 2019
    Publication date: May 21, 2020
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • METHODS FOR ENANTIOSELECTIVE ALLYLIC ALKYLATION OF ESTERS, LACTONES, AND LACTAMS WITH UNACTIVATED ALLYLIC ALCOHOLS
    Publication number: 20200048201
    Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic ?-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
    Type: Application
    Filed: July 15, 2019
    Publication date: February 13, 2020
    Inventors: Brian M. Stoltz, Aurapat Ngamnithiporn, Carina I. Jette, Shoshana Bachman, Scott C. Virgil, Sebastian Lackner
  • Methods for preparing bis-tetrahydroisoquinoline-containing compounds
    Patent number: 10526334
    Abstract: (?)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: January 7, 2020
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Eric R. Welin, Scott C. Virgil, Pamela Tadross, Gerit Maria Pototschnig, Aurapat (Fa) Ngamnithiporn, Kenji Negoro, Guillaume Lapointe, Max Klatte, Christopher Haley, Christian Gruenanger, Emil Glibstrup, Christopher Gilmore, Kevin McCormack Allan
  • Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
    Patent number: 10358422
    Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic ?-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: July 23, 2019
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Aurapat Ngamnithiporn, Carina I. Jette, Shoshana Bachman, Scott C. Virgil, Sebastian Lackner
  • Quaternary heteroatom containing compounds
    Patent number: 10343996
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: July 9, 2019
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • METHODS FOR ENANTIOSELECTIVE ALLYLIC ALKYLATION OF ESTERS, LACTONES, AND LACTAMS WITH UNACTIVATED ALLYLIC ALCOHOLS
    Publication number: 20190135754
    Abstract: The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic ?-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.
    Type: Application
    Filed: November 1, 2018
    Publication date: May 9, 2019
    Inventors: Brian M. Stoltz, Aurapat Ngamnithiporn, Carina I. Jette, Shoshana Bachman, Scott C. Virgil, Sebastian Lackner
  • Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds
    Publication number: 20190048009
    Abstract: (?)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of treating proliferative diseases with the same are provided.
    Type: Application
    Filed: July 18, 2018
    Publication date: February 14, 2019
    Inventors: Brian M. Stoltz, Eric R. Welin, Scott C. Virgil, Pamela Tadross, Gerit Maria Pototschnig, Aurapat (Fa) Ngamnithiporn, Kenji Negoro, Guillaume Lapointe, Max Klatte, Christopher Haley, Christian Gruenanger, Emil Glibstrup, Christopher Gilmore, Kevin McCormack Allan
  • QUATERNARY HETEROATOM CONTAINING COMPOUNDS
    Publication number: 20180339968
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 29, 2018
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Quaternary heteroatom containing compounds
    Patent number: 10035769
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: July 31, 2018
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Scott C. Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • QUATERNARY HETEROATOM CONTAINING COMPOUNDS
    Publication number: 20170137382
    Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
    Type: Application
    Filed: December 1, 2016
    Publication date: May 18, 2017
    Inventors: Brian M. Stoltz, Scott C Virgil, David E. White, Taiga Yurino, Yiyang Liu, Douglas C. Behenna, Douglas Duquette, Christian Eidamshaus
  • Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof
    Patent number: 9422259
    Abstract: Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: August 23, 2016
    Assignee: California Institute of Technology
    Inventors: Hosea Nelson, Kei Murakami, Scott C. Virgil, Brian M. Stoltz, Jonathan R. Gordon