Abstract: The present disclosure relates to a bioreactor assembly having a housing defining an interior chamber; a lid assembly removably coupled to the housing and enclosing the interior chamber; and a gimbal assembly disposable within the interior chamber. The gimbal assembly includes a cradle configured to hold an organ or organ scaffold and an arm assembly configured to move the cradle between a plurality of positions. The bioreactor assembly also includes an ultrasound imaging unit positioned to capture volumetric and/or spatial data of the organ or organ scaffold.

Abstract: End effector assemblies according to the present disclosure include a tool body mounted to a robotic arm and an impedance-measuring tip coupled to the tool body. The impedance-measuring tip defines a first volume to receive a fluid and a first dispensing outlet for dispensing the fluid. The impedance-measuring tip includes an impedance-measuring sensor configured to output a signal indicative of a change in impedance. A tip extension is fluidically coupled to the impedance-measuring tip that defines a second volume for receiving the fluid. A camera is coupled to the tool body and configured to capture image data of the second volume that captures at least a visual representation of a number of cells or other objects in the second volume. A pump is coupled to the impedance-measuring tip to dispense the fluid from the first volume into the second volume and from the second volume into a receptacle.

Abstract: A modular light for removably attaching to a bio-printer robot end effector, where the light includes: an annular modular light ring housing with an annular opening for receiving the end effector of the bioprinting robot; the housing substantially surrounding a dispensing tip of the end effector; a power supply interface to receive electrical power from the end effector; a plurality of LEDs positioned annularly around the end effector within the annular modular light ring housing, where the plurality of LEDs are spaced in at least two annular rows, where each of the at least two annular rows are at a unique elevational position within the annular modular light ring housing with respect to a light output plane of the annular modular light ring housing; the LEDs are in electrical communication with the power supply interface; and a controller communicatively coupled with the LEDs and the power supply interface.

Abstract: A modular platform for a bioassembly system includes a platform frame and one or more removable stage inserts. The frame has a receiving portion and one or more frame electrical connections. Each removable stage insert is respectively configured to be received in the receiving portion of the platform frame in an inserted position. Each removable stage insert includes one or more insert electrical connections communicatively coupled to the one or more frame electrical connections when in the inserted position. The bioassembly system also includes a controller and a communicatively coupled memory including machine-readable instructions.

Abstract: A 3D printing assembly, system, and method for 3D printing a biomaterial may include a robotic arm end effector and a barrel clamp assembly. The robotic arm end effector is configured to move along one or more axes of movement for 3D printing. The barrel clamp assembly is distally coupled to the robotic arm end effector and includes a barrel clamp arm and a barrel clamp. The barrel clamp arm includes a top end coupled to the robotic arm end effector and a bottom end opposite to the top end. The bottom end is angled forward with respect to the top end. The barrel clamp is coupled to the bottom end of the barrel clamp arm and is configured to receive and clamp against a distal end of a printing syringe barrel for 3D printing.

Abstract: A tiltable stage assembly includes a base and a tiltable stage operably coupled to the base and pivotable relative to the base. The tiltable stage is moveable between an initial position and a tilted position, wherein the tiltable stage is parallel with the base in the initial position and is oriented at an angle to the base when in the tilted position. The tiltable stage is biased to the initial position.

Abstract: A biofabrication system includes a workstation and an articulating arm disposed within a work area of a biosafety cabinet. The workstation includes a stage for biofabrication. The biosafety cabinet includes an integration port that provides access to the work area through a wall of the biosafety cabinet. The articulating arm may be positioned to reach the workstation and the integration port.

Abstract: A modular light for removably attaching to a bio-printer robot end effector, where the light includes: an annular modular light ring housing with an annular opening for receiving the end effector of the bioprinting robot; the housing substantially surrounding a dispensing tip of the end effector; a power supply interface to receive electrical power from the end effector; a plurality of LEDs positioned annularly around the end effector within the annular modular light ring housing, where the plurality of LEDs are spaced in at least two annular rows, where each of the at least two annular rows are at a unique elevational position within the annular modular light ring housing with respect to a light output plane of the annular modular light ring housing; the LEDs are in electrical communication with the power supply interface; and a controller communicatively coupled with the LEDs and the power supply interface.

Abstract: A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuatable damper is disposed within the housing for selectively restricting a collection flow.

Abstract: An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.

Abstract: An interchangeable preconcentrator assembly for delivering an analyte to an analysis instrument. The assembly includes a housing defining an inner chamber. An inlet is in fluid communication with the inner chamber, an outlet is in fluid communication with the inner chamber for delivering fluid to the inlet of the analysis instrument, and an exhaust outlet is in fluid communication with the inner chamber. A plurality of removable preconcentrator packages are disposed within the inner chamber. Each of the removable preconcentrator packages including a microscale preconcentrator. A fluid flow path is defined between the inlet and the inner chamber. A first fluid flow path is defined between the preconcentrators and the exhaust outlet, and a second fluid flow path is defined between the preconcentrators and the outlet. A selectably operable valve directs fluid flow from the inner chamber into either the first fluid flow path or the second fluid flow path.

Abstract: An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urging member is at least partially retracted, a space is defined between the urging member and the surface of the inner housing for accommodating at least one preconcentrator chip. A continuous fluid flow path is defined through the outer housing and through the space. The interchangeable preconcentrator assembly may further comprise at least one modular preconcentrator carriage.

Abstract: A large volume preconcentrator device for concentrating analytes. A housing accepts an analyte vapor flow, and a plurality of collection surfaces are disposed within the housing. A selectively actuatable heater is disposed on each of the plurality of collection surfaces. At least one selectively actuable damper is disposed within the housing for selectively restricting a collection flow.

Abstract: An interchangeable preconcentrator assembly comprises an outer housing and an inner housing defining a chamber. A biased urging member is held at least partially within the outer housing and slidably biased toward a surface of the inner housing. When the biased urging member is at least partially retracted, a space is defined between the urging member and the surface of the inner housing for accommodating at least one preconcentrator chip. A continuous fluid flow path is defined through the outer housing and through the space. The interchangeable preconcentrator assembly may further comprise at least one modular preconcentrator carriage.