Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: A method for graphical information de-biasing is described. The method includes detecting biased graphical information presented to a user. The method also includes generating a neutral version of the biased graphical information to form de-biased graphical information. The method further includes displaying the de-biased graphical information to the user, including highlighted components of the de-biased graphical information.

Abstract: A method for graphical information de-biasing is described. The method includes detecting biased graphical information presented to a user. The method also includes generating a neutral version of the biased graphical information to form de-biased graphical information. The method further includes displaying the de-biased graphical information to the user, including highlighted components of the de-biased graphical information.

Abstract: In accordance with one embodiment of the present disclosure, a system includes a processor, a memory communicatively coupled to the processor, and machine-readable instructions stored in the memory. The machine-readable instructions, when executed by the processor, cause the processor to perform operations including receiving a multimedia file having a metadata and a text data, the multimedia file and the text data corresponding to a user. Operations also include determining a reliability status of the multimedia file based on the multimedia file, the text data, or combinations thereof. Operations further include determining a bias status of the user based on the multimedia file, the text data, or combinations thereof, and generating a report comprising the reliability status and the bias status of the multimedia file.

Abstract: A method for monitoring user decision making activity is described. The method includes logging a user decision and decision communications corresponding to the user decision. The method also includes identifying the user decision as a compromised user decision based on an emotional status of a user determined from the decision communications. The method further includes determining a subsequent emotional status of the user based on a subsequent user communication corresponding to the compromised user decision. The method also includes providing an advice recommendation to the user when a degraded emotional status is detected regarding the compromised decision.

Abstract: A method comprises identifying a representation of first statistical information in a document, identifying descriptive text that describes the first statistical information, determining whether the descriptive text accurately describes the first statistical information, and upon determination that the descriptive text does not accurately describe the first statistical information, generating alternative descriptive text that accurately describes the first statistical information.

Abstract: The present invention provides oxaborole ester compounds and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis.

Abstract: Methods, systems, and non-transitory machine-readable mediums for ranking on an absolute scale include displaying, on an electronic display, a first handle, a second handle, and an interactor, determining a value of the first handle and a value of the second handle based on their respective positions on the interactor, in response to a user dragging the first and second handles on the interactor, and determining a rank of the first and second handles based on the values of the first and second handles, in response to the user dragging the first and second handles on the interactor.

Abstract: Example implementations described herein involve systems and methods for a mobile application device to playback and record augmented reality (AR) overlays indicating gestures to be made to a recorded device screen. A device screen is recorded by a camera of the mobile device, wherein a mask is overlaid on a user hand interacting with the device screen. Interactions made to the device screen are detected based on the mask, and AR overlays are generated corresponding to the reactions.

Abstract: The present invention is directed to a method of cleaning and inspection of drilling mud carrying flow lines, each flow line having an inner surface. The method includes affixing a fitting to the flow line, the fitting having a main flow channel and a branch flow channel extending at an angle from said main flow channel. A first end portion of the fitting can have an attachment that enables connection of the fitting to the flow line at one flow line end portion. A second end portion of the fitting can have one or more doors that can be moved between opened and closed positions, the door or doors providing an opening that is not closed when the doors are in the closed position. A suction line can be connected to the branch flow channel. A cleaning tool can be guided first into the fitting and then into the flow line using a fluid carrying cable. The cleaning tool and jetting fluid can be used to clean drilling mud and debris from the inner surface of the flow line.

Abstract: The present invention relates to safety caps for lancing procedures, and a method of cleaning piping systems using said safety caps. More particularly, the present invention relates to an improved safety cap for oil and gas well pipes to be cleaned onsite that allows for the cap and lancing tools to be used in hard-to-reach places.

Abstract: Example implementations described herein systems and method for providing a platform to facilitate augmented reality (AR) overlays, which can involve stabilizing video received from a first device for display on a second device and for input made to a portion of the stabilized video at the second device, generating an AR overlay on a display of the first device corresponding to the portion of the stabilized video.

Abstract: The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor.

Abstract: A computer-implemented method performed in connection with a video comprising a plurality of video frames, the computer-implemented method being performed in a computerized system comprising a processing unit and a memory, the computer-implemented method involving: using the processing unit to detect a plurality of content components within at least one of the plurality of video frames; based on a video modification instruction received from a user, modifying at least one of the plurality of the detected content components; storing an information on the modified at least one of the plurality of the detected content components in the memory; using the central processing unit to overlay the modified at least one of the plurality of the detected content components over the video; and causing the video with the overlaid modified content component to be displayed to the user.

Abstract: The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. In certain embodiments of the methods disclosed herein, the methods include administering to the subject a compound as disclosed herein and a peripherally acting P-blocker (PABRA).

Abstract: A computerized system comprising a processing unit and a memory, the system operating in connection with a real-time video conference stream containing a video of a user, wherein the memory embodies a set of computer-executable instructions, which cause the computerized system to perform a method involving: receiving the real time video conference stream containing the video of the user; detecting and separating the background in the received real time video conference stream from the user; and replacing the separated background with a background received from a system of a second user or with a pre-recorded background.

Abstract: A computerized system comprising a processing unit and a memory, the system operating in connection with a real-time video conference stream containing a video of a user, wherein the memory embodies a set of computer-executable instructions, which cause the computerized system to perform a method involving: receiving the real time video conference stream containing the video of the user; detecting the background in the received real time video conference stream from the user; and matching the first background and a second background associated with the second user.

Abstract: Systems and methods detect simple user gestures to enable selection of portions of segmented content, such as text, displayed on a display. Gestures may include finger (such as thumb) flicks or swipes as well as flicks of the handheld device itself. The used finger does not occlude the selected text, allowing users to easily see what the selection is at any time during the content selection process. In addition, the swipe or flick gestures can be performed by a non-dominant finger such as a thumb, allowing users to hold the device and make the selection using only one hand. After making the initial selection of a target portion of the content, to extend the selection, for example to the right, the user simply swipes or flicks the finger over the touchscreen to the right. The user could also flick the entire device in a move gesture with one hand.

Abstract: To prevent the spread of hospital-acquired infections, embodiments described herein monitor mobile device usage in clinical settings (by a physician, nurse, etc.) to characterize potential pathogenic contamination of the mobile device, the user's hands, and the surfaces in contact with the device. Our method considers the physical properties of how the device is handled and held during use, as well as the location and setting before, during, and after use to estimate potential contamination and transmission of pathogens. A system can use the estimation, along with knowledge (e.g., of the user's upcoming schedule) to alert them of potential contamination hazards and suggest when to avoid mobile device use as well as when to sanitize the device and user's hands.

Abstract: In various examples, a header of an implantable device includes a first header portion and a second header portion at least partially disengageable from the first header portion. In a closed configuration, the first header portion is fully engaged with the second header portion, and in an open configuration, the first header portion is at least partially disengaged from the second header portion. At least one bore within the header is sized and shaped to accommodate a proximal end of a lead. The bore is split substantially longitudinally to form a first bore portion and a second bore portion. With the proximal end of the lead disposed within the bore and a positioning feature interacting with a lead feature, at least one lead contact aligns with at least one header contact to allow the at least one lead contact to electrically couple to the at least one header contact.