Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for endocrine diseases, including hypothyroidism. In particular, the invention provides methods for patient selection and methods of treatment.

Abstract: Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for dermatological autoimmune diseases. In particular, the invention provides methods for patient selection and methods of treatment.

Abstract: A fuel pump system having a servo controlled pump bypass is utilized. The servo controlled bypass around the fuel pump provides the capability for the fuel flow rate to be adjusted and controlled independent of the fuel metering system.

Abstract: A system for fluid temperature control and actuation control for an aircraft engine fueled by dual fuels. The system includes a first fuel system having a first fuel tank fluidly coupled to the engine, a second fuel system having a second fuel tank fluidly coupled to the engine, with the second fuel being different from the first fuel and having a different temperature than the first fuel, a fuel distribution unit (FDU) fluidly coupled to the first fuel tank of the first fuel system, and a fuel-to-fuel cooler (FFC) configured to transfer heat between the first fuel in the first fuel system and the second fuel in the second fuel system.

Abstract: The present disclosure provides improved dimming or dimmer assemblies/modules for controlling lights or loads (e.g., as part of a control or automation system). More particularly, the present disclosure provides for systems and methods for utilizing dimmer control assemblies/modules advantageously having: (i) an adjustable output response, (ii) enhanced thermal management, (iii) a voltage detector to determine amplitude and zero-crossing, and/or (iv) an estimation of power consumption for multiple loads (e.g., using a single sensor).

Abstract: A fuel pump system having a servo controlled pump bypass is utilized. The servo controlled bypass around the fuel pump provides the capability for the fuel flow rate to be adjusted and controlled independent of the fuel metering system.

Abstract: A system for fluid temperature control and actuation control for an aircraft engine fueled by dual fuels. The system includes a first fuel system having a first fuel tank fluidly coupled to the engine, a second fuel system having a second fuel tank fluidly coupled to the engine, with the second fuel being different from the first fuel and having a different temperature than the first fuel, a fuel distribution unit (FDU) fluidly coupled to the first fuel tank of the first fuel system, and a fuel-to-fuel cooler (FFC) configured to transfer heat between the first fuel in the first fuel system and the second fuel in the second fuel system.

Abstract: The present disclosure provides improved dimming or dimmer assemblies/modules for controlling lights or loads (e.g., as part of a control or automation system). More particularly, the present disclosure provides for systems and methods for utilizing dimmer control assemblies/modules advantageously having: (i) an adjustable output response, (ii) enhanced thermal management, (iii) a voltage detector to determine amplitude and zero-crossing, and/or (iv) an estimation of power consumption for multiple loads (e.g., using a single sensor).

Abstract: A system and method for real-time revenue management is provided. Data is received from a scheduling system pertaining to a network comprising a plurality of legs. A sub-network within the network may be identified, and optimization of the sub-network is triggered. A current inventory information value attributable to the identified sub-network is pro-rated, and an expected traffic value for the identified sub-network is calculated using a forecast of the expected demand, a standard deviation of the demand, a gamma distribution equation, and an unsatisfied demand value. An updated inventory information value for the identified sub-network is generated using the pro-rated inventory information value and an optimization equation, wherein the optimization equation generates a maximum revenue value by adjusting the expected traffic, and the updated inventory information value is transmitted to the scheduling system.

Abstract: A dual fuel engine control system comprising a first fuel control system configured to control the flow of a first fuel to an aircraft gas turbine engine, and a second fuel control system configured to control the flow of a second fuel to the aircraft gas turbine engine.

Abstract: A system and method for real-time revenue management is provided. Data is received from a scheduling system pertaining to a network comprising a plurality of legs. A sub-network within the network may be identified, and optimization of the sub-network is triggered. A current inventory information value attributable to the identified sub-network is pro-rated, and an expected traffic value for the identified sub-network is calculated using a forecast of the expected demand, a standard deviation of the demand, a gamma distribution equation, and an unsatisfied demand value. An updated inventory information value for the identified sub-network is generated using the pro-rated inventory information value and an optimization equation, wherein the optimization equation generates a maximum revenue value by adjusting the expected traffic, and the updated inventory information value is transmitted to the scheduling system.

Abstract: The present disclosure provides for a display device for interfacing with a control and/or automation system. More particularly, the present disclosure provides for an improved display device for interfacing with a control and/or automation system, wherein the electronic display device includes a motion sensor or the like. In exemplary embodiments, the motion sensor is configured to detect at least one of motion or proximity of a human being without being contacted by the human being, the non-contact motion sensor also being configured to activate and/or adjust the illumination/light level of the display/screen from a first illumination/light level to a second illumination/light level when the non-contact motion sensor detects at least one of motion or proximity of a human being.

Abstract: A field data collection and relay station is equipped to receive sensor data from locations in a region. The station has directional antennas that are focused to transmit and receive energy in and from unique directions. The station establishes a wireless network in which the sensor data is formatted and distributed to one or more of the directional antennas. As a result, the sensor data is wirelessly transmitted in at least one unique direction.

Abstract: A system and method for imaging underbodies of moving vehicles have a stationary source of radiation to radiate energy upwardly on underbodies of moving vehicles. A stationary video camera adjacent the radiation source on a roadway has an upwardly facing field of view for creating image signals representative of sequential portions of each underbody as each moving vehicle passes overhead. A control station activates the camera and radiation source to create the image signals and creates mosaic signals of all of each underbody from the image signals. A display screen provides a mosaic image of each underbody from its mosaic signals. A virtually real-time inspection or a comparison can be made with previously taken underbody images of the same moving vehicle or with vehicle manufacturers' data for the same vehicular models. Moving cars, trucks, marine vessels, aircraft, can be quickly imaged for inspection and/or comparison by fewer security personnel.

Abstract: A variable speed, constant temperature laminator including a slot with a terminal portion for receiving perfect binders, rollers for applying heat and pressure to items to be laminated therebetween, a channel for feeding the items to be laminated between the rollers, a heater disposed along a length of the channel terminating in at least one arcuate fin member disposed closely adjacent to and at least partially about the rollers, the heater further includes a thin walled portion proximate the terminal portion of the slot for heating perfect binders received in the slot; and a driver for driving the rollers at variable speeds for maintaining a constant actual temperature for the heater and constant pressure while achieving a variable effective temperature for items passing between the rollers.

Abstract: A low mass heater is disclosed for rapid heat-up having thin arcuate heater portions adjacent the rollers and separated therefrom by a narrow gap for injecting heat into peripheral portions of the rollers. These arcuate portions may be ductile and have slots therein for adjusting the gap, and also include finger members for self-cleaning of the rollers. A notch is formed in a heater portion for easy lamination of a perfect binder of a booklet. Also, the laminator casing is shaped in the form of a dome having air passage slots therein, which eliminates the need for a cooling fan for the electronic components of the laminator. The dome shape also provides a large sloping surface for an ergonomic control arrangement. After lamination of a first batch of plastic envelopes requiring high laminating temperatures, a second batch requiring low temperatures can be immediately laminated without waiting for cooling down of the heater, by increasing the angular drive roller velocity.