Abstract: Examples include a coordinator device broadcasting a route request identifying a destination device, to neighbor routers over reception paths. The neighbor routers then store a respective route record, indicating each as an end node in an in-progress path from the coordinator device to the destination device, and rebroadcast the route request for reception by next increment router neighbors. The next increment router neighbors, responsive to receiving the rebroadcasts, estimate a quality between good hop and bad hop of their reception paths, and determine, as an evaluation total path quality, a quality of a candidate hop path from the coordinator device to the next increment router neighbor. The next increment router neighbors determine if they have extant hop connection to the coordinator device with path quality at least as good as the evaluation total path quality. If “no,”, the next increment router neighbor increments the hop sequence by one hop.

Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

Abstract: Various examples are provided related to attachment of tape or strips of material along a seam of a garment or other material. In one example, among others, a robotic system includes a joining device that can attach a tape or strip of material across a seam, a loading system that can position material with the seam for attachment of the tape or strip of material, a seam feed system that can adjust positioning of the material for attachment, and a tape handling system that can supply the tape or strip of material to the joining head of the joining device for attachment across the seam. A tape handling system can include a tape joining assembly that can receive tape or strip of material from a current tape cartridge and bond it to the tape or strip of material clamped by the tape joining assembly.

Abstract: Various examples are provided related to attachment of tape or strips of material along a seam of a garment or other material. In one example, among others, a robotic system includes a joining device that can attach a tape or strip of material across a seam, a loading system that can position material with the seam for attachment of the tape or strip of material, a seam feed system that can adjust positioning of the material for attachment, and a tape handling system that can supply the tape or strip of material to the joining head of the joining device for attachment across the seam. A tape handling system can include a tape joining assembly that can receive tape or strip of material from a current tape cartridge and bond it to the tape or strip of material clamped by the tape joining assembly.

Abstract: Disclosed herein are otic formulations and compositions comprising growth factors. These otic formulations and compositions allow for the delivery of the growth factor to the outer, middle, and/or inner ear for the treatment of otic diseases and disorders.

Abstract: The present invention provides compositions comprising one or more active pharmaceutical ingredients, wherein the compositions are in the form of high solids concentration pastes capable of being injected in relatively low volumes into an animal using standard commercially available syringes. The invention also provides methods of making such compositions, particularly those compositions comprising high molecular weight active ingredients (e.g., antibodies, enzymes and other proteins and peptides) at relatively high therapeutic concentrations in the high solids concentration pastes. The invention further provides methods of using such formulations in treating, preventing and/or ameliorating certain diseases and physical disorders in animals, including humans, in need thereof. The invention also provides kits comprising the formulations of the invention and a suitable syringe, which in some aspects may be pre-loaded or pre-filled with a composition of the invention.

Abstract: The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus: wherein —R15 is a group: and —R16 is hydrogen; —R17 is hydrogen; -L- is a covalent bond or methylene; and —Ar is optionally substituted aryl. The groups —X—, —R1, —R2, —R3, —R4, and —R8 are as defined herein.

Abstract: An intercommunication system includes one or more modular units utilizing a standards-based audio-over-IP configuration. The modularity of the system provides improved scalability. For instance, a number of audio channels is not limited by physical constraints (e.g. number and type of ports) of a central switch. Accordingly, the addition of audio channels may not require swapping one central switch for a larger switch. Moreover, security applications may be layered onto the standards-based audio-over-IP configuration to implement security requirements often found with intercommunications systems.

Abstract: The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus: wherein —R15 is a group: and —R16 is hydrogen; —R17 is hydrogen -L- is a covalent bond or methylene; and —Ar is optionally substituted aryl. The groups —X—, —R1, —R2, —R3, —R4, and —R8 are as defined herein.

Abstract: The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus: wherein —R15 is a group: and —R16 is hydrogen; —R17 is hydrogen -L- is a covalent bond or methylene; and —Ar is optionally substituted aryl. The groups —X—, —R1, —R2, —R3, —R4, and —R8 are as defined herein.

Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

Abstract: An apparatus may mount an in-stream, continuous contact, visible, sacrificial anode in a fluid passage for the electrolytic corrosion protection. The apparatus may function to protect heat exchangers and/or other metallically connected system components that share contact with electrolytically active fluids. The apparatus may consist of an in-line anode cartridge including a collar body and a viewing port. The apparatus may include a site glass and compression fittings which seals the device causing corrosive fluids to flow past a sacrificial anode. The apparatus may include a visual indicator and an elastically compressed member (e.g., spring) which facilitate continuous metallic/electrical contact and inspection of the anode through the viewing port without system shut down or disassembly. The elastically compressed member and gauge assembly fills the view-ports with a bright indicator as the anode dissolves and the elastically compressed member expands.

Abstract: A patient monitoring system includes sensors, a patient support assembly, and a gateway device and/or control module. Example sensors include physiological sensors and patient status devices. The sensors acquire patient-related data. Patient related action is determined based on the patient-related data.

Abstract: In some embodiments, a method may bond titanium to an intermediate alloy. The method may include layering a portion of an intermediate alloy onto a portion of titanium. The method may include focusing a controlled heat source on a spot of the intermediate alloy to form a weld pool in the intermediate alloy at the spot. The method may include superheating the intermediate alloy in the weld pool above the melting point of the intermediate alloy but below the melting point of titanium such that liquid intermediate alloy contacts the surface of the portion of the titanium heating the portion of the titanium. The method may include diffusing the portions of titanium and intermediate alloy together such that upon the intermediate alloy cooling below the melting point of the intermediate alloy the portions of the intermediate alloy and titanium are bonded forming a weldment.

Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

Abstract: Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from medium chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.

Abstract: In some embodiments, a method may bond titanium to an intermediate alloy. The method may include layering a portion of an intermediate alloy onto a portion of titanium. The method may include focusing a controlled heat source on a spot of the intermediate alloy to form a weld pool in the intermediate alloy at the spot. The method may include superheating the intermediate alloy in the weld pool above the melting point of the intermediate alloy but below the melting point of titanium such that liquid intermediate alloy contacts the surface of the portion of the titanium heating the portion of the titanium. The method may include diffusing the portions of titanium and intermediate alloy together such that upon the intermediate alloy cooling below the melting point of the intermediate alloy the portions of the intermediate alloy and titanium are bonded forming a weldment.

Abstract: This disclosure provides a method of treating a bacterial infection in a human patient comprising by administering a therapeutically effective dose of SPR741, a polymyxin analog, in combination with a therapeutically effective amount of an antibiotic other than SPR741. The disclosure establishes 100 mg to 500 mg of SPR741, administered 2 to 4 times daily as the effective amount of SPR741 for co-administration with a therapeutically effective amount of a second antibiotic. The disclosure also provides a method of treating a bacterial infection comprising administering 40 mg/kg patient weight/day or less and preferably 5 mg/kg patient weight/day or less of SPR741 in combination with a therapeutically effective amount of a second antibiotic.

Abstract: An apparatus may mount an in-stream, continuous contact, visible, sacrificial anode in a fluid passage for the electrolytic corrosion protection. The apparatus may function to protect heat exchangers and/or other metallically connected system components that share contact with electrolytically active fluids. The apparatus may consist of an in-line anode cartridge including a collar body and a viewing port. The apparatus may include a site glass and compression fittings which seals the device causing corrosive fluids to flow past a sacrificial anode. The apparatus may include a visual indicator and an elastically compressed member (e.g., spring) which facilitate continuous metallic/electrical contact and inspection of the anode through the viewing port without system shut down or disassembly. The elastically compressed member and gauge assembly fills the view-ports with a bright indicator as the anode dissolves and the elastically compressed member expands.