Abstract: The present disclosure provides compositions, methods, and systems related to genome editing technology. In particular, the present disclosure provides a novel CRISPR-based genome editing technology that involves the generation of abasic sites to facilitate genetic recombination, without the need for breaks in the DNA. The compositions, methods, and systems described herein address many of the drawbacks of currently available approaches, including off-target effects and cellular toxicity.

Abstract: Systems and methods are provided for identifying broadcast sources within a MapView system. A MapView system may display a first representation of a first geographical area that includes icons representing a location of broadcast sources. User characteristics may be extracted from a first user device associated with the MapView system. A machine-learning model may execute using the user characteristics to generate contemporaneous broadcast characteristics corresponding to a user of the first user device. The MapView system may then display a second representation of the geographical area that includes icons representing a location of different broadcast sources. The MapView system may then facilitate a presentation of particular broadcast source from the different broadcast sources.

Abstract: Described are systems and methods to determine a content item recommendation that is included in a content item bid request, recommending to a third party, a third party content item to include in a content item bid that is responsive to the bid request. The content item recommendation may indicate a particular third party product or third party content item that is predicted to perform well in a content item slot and for a specific user without disclosing user information to the third party.

Abstract: Systems and methods are provided for presenting media streams based on changes in geolocation. A MapView system may receive a first positioning signal indicating a first geographical location of a user device. The MapView system may determine a first media stream to be presented by the user device based on the first geographical location and a location of a source of the first media stream. The MapView system may then facilitate a presentation of the first media stream by the user device. When the MapView system receives a second positioning signal indicating a second geographical location of the user device, the MapView may identify, a second media stream to be presented by the user device based on the second geographical location being in broadcast range of the second media stream. The MapView system may then facilitate a presentation of the second media stream by the user device.

Abstract: An autonomous transport vehicle includes a frame forming a payload section configured to hold one or more pickfaces, a transfer arm movably mounted to the frame, a drive section connected to the frame, and a controller connected to the drive section, the controller being configured to effect an on-the-fly sortation of pickfaces carried by the autonomous transport vehicle according to a predetermined case out order sequence where the controller commands the drive section so that two or more pickfaces are picked from one or more first case unit holding locations and placed at one or more different second case unit holding locations according to the predetermined case out order sequence.

Abstract: Systems and methods are provided for presenting media streams based on changes in geolocation. A MapView system may receive a first positioning signal indicating a first geographical location of a user device. The MapView system may determine a first media stream to be presented by the user device based on the first geographical location and a location of a source of the first media stream. The MapView system may then facilitate a presentation of the first media stream by the user device. When the MapView system receives a second positioning signal indicating a second geographical location of the user device, the MapView may identify, a second media stream to be presented by the user device based on the second geographical location being in broadcast range of the second media stream. The MapView system may then facilitate a presentation of the second media stream by the user device.

Abstract: Systems and methods are provided for presenting media streams based on changes in geolocation. A MapView system may receive a first positioning signal indicating a first geographical location of a user device. The MapView system may determine a first media stream to be presented by the user device based on the first geographical location and a location of a source of the first media stream. The MapView system may then facilitate a presentation of the first media stream by the user device. When the MapView system receives a second positioning signal indicating a second geographical location of the user device, the MapView may identify, a second media stream to be presented by the user device based on the second geographical location being in broadcast range of the second media stream. The MapView system may then facilitate a presentation of the second media stream by the user device.

Abstract: A power tool includes a housing including an electric motor, a work element, a shaft extending between the housing and the work element, and a clamp coupled to the shaft and extending along a longitudinal axis between a first end and a second end. The shaft includes an outer shaft and an inner shaft. The clamp is actuatable between a locked position and an unlocked position. The inner shaft is configured to slide longitudinally within the outer shaft when the clamp is in the unlocked position. The outer shaft and the inner shaft are secured in a desired position when the clamp is in the locked position.

Abstract: Features relating to a vaporizer device including a reusable vaporizer device body are provided. The vaporizer device includes a hybrid heating system including a convection heater and/or a conduction heater for rapidly heating vaporizable material stored in the vaporizer device.

Abstract: Systems and methods are provided for presenting media streams based on changes in geolocation. A MapView system may receive a first positioning signal indicating a first geographical location of a user device. The MapView system may determine a first media stream to be presented by the user device based on the first geographical location and a location of a source of the first media stream. The MapView system may then facilitate a presentation of the first media stream by the user device. When the MapView system receives a second positioning signal indicating a second geographical location of the user device, the MapView may identify, a second media stream to be presented by the user device based on the second geographical location being in broadcast range of the second media stream. The MapView system may then facilitate a presentation of the second media stream by the user device.

Abstract: An autonomous transport vehicle includes a frame forming a payload section configured to hold one or more pickfaces, a transfer arm movably mounted to the frame, a drive section connected to the frame, and a controller connected to the drive section, the controller being configured to effect an on-the-fly sortation of pickfaces carried by the autonomous transport vehicle according to a predetermined case out order sequence where the controller commands the drive section so that two or more pickfaces are picked from one or more first case unit holding locations and placed at one or more different second case unit holding locations according to the predetermined case out order sequence.

Abstract: The technology described herein relates to a system and device for saturating an absorbent wicking nib with colored ink supplied by an ink pad having a well configured to receive a portion of the sidewall of the nib. Different colors of ink can be transferred to different portions of the nib sidewall to result in a multicolor marker nib.

Abstract: An autonomous transport vehicle includes a frame forming a payload section configured to hold one or more pickfaces, a transfer arm movably mounted to the frame, a drive section connected to the frame, and a controller connected to the drive section, the controller being configured to effect an on-the-fly sortation of pickfaces carried by the autonomous transport vehicle according to a predetermined case out order sequence where the controller commands the drive section so that two or more pickfaces are picked from one or more first case unit holding locations and placed at one or more different second case unit holding locations according to the predetermined case out order sequence.

Abstract: Systems and methods are provided for presenting media streams based on changes in geolocation. A MapView system may receive a first positioning signal indicating a first geographical location of a user device. The MapView system may determine a first media stream to be presented by the user device based on the first geographical location and a location of a source of the first media stream. The MapView system may then facilitate a presentation of the first media stream by the user device. When the MapView system receives a second positioning signal indicating a second geographical location of the user device, the MapView may identify, a second media stream to be presented by the user device based on the second geographical location being in broadcast range of the second media stream. The MapView system may then facilitate a presentation of the second media stream by the user device.

Abstract: Systems and methods are provided for identifying broadcast sources within a MapView system. A MapView system may display a first representation of a first geographical area that includes icons representing a location of broadcast sources. User characteristics may be extracted from a first user device associated with the MapView system. A machine-learning model may execute using the user characteristics to generate contemporaneous broadcast characteristics corresponding to a user of the first user device. The MapView system may then display a second representation of the geographical area that includes icons representing a location of different broadcast sources. The MapView system may then facilitate a presentation of particular broadcast source from the different broadcast sources.

Abstract: Methods for an instrument including a light source of are provided. A method for an instrument including a light source includes providing light from the light source to a target location in a process chamber. The method includes receiving the light at a sensor. The method includes determining, using data from the sensor, a first position of the light at the target location. Moreover, the method includes determining whether to adjust the light to a second position at the target location. Related instruments are also provided.

Abstract: Slide analysis a gripper with three sensors for controlling a slide grip sequence and at least one rotatable carousel with a slide receiving channel. The systems also include a robot with a robot arm that holds a slide gripper residing inside the housing in communication with the rotatable carousel. The systems also include a load lock chamber and a door sealably coupled to the second end portion and an acquisition vacuum chamber with an X-Y stage and a slide holder with a vacuum seal.

Abstract: The present disclosure provides compositions, methods, and systems related to genome editing technology. In particular, the present disclosure provides a novel CRISPR-based genome editing technology that involves the generation of abasic sites to facilitate genetic recombination, without the need for breaks in the DNA. The compositions, methods, and systems described herein address many of the drawbacks of currently available approaches, including off-target effects and cellular toxicity.