Patents by Inventor Scott D. Larsen

Scott D. Larsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for targeting cancer stem cells
    Patent number: 9468632
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: October 18, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ronald Buckanovich, Scott D. Larsen, Kun Yang
  • PPAR-SPARING COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
    Publication number: 20160152570
    Abstract: The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation mediated diseases such as diabetes, obesity, hypertension, dyslipidemia, a neurodegenerative disorder (e.g., Alzheimer's disease, Parkinson's disease, or Huntington's disease), or any combination thereof. Moreover, the present invention also provides methods of treatment for these diseases or disorders.
    Type: Application
    Filed: July 21, 2014
    Publication date: June 2, 2016
    Inventors: Steven P. Tanis, Scott D. Larsen, Gerald D. Artman, III, Timothy Parker
  • INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME
    Publication number: 20160145251
    Abstract: Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
    Type: Application
    Filed: November 6, 2015
    Publication date: May 26, 2016
    Inventors: Scott D. Larsen, Richard Neubig, Andrew Haak, Kim Hutchings, Walajapet Rajeswaran
  • METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
    Publication number: 20150297577
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against cancer stem cells.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 22, 2015
    Inventors: Ronald Buckanovich, Scott D. Larsen, Kun Yang
  • METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES AND CONDITIONS
    Publication number: 20150250769
    Abstract: The present disclosure relates to methods, compositions, and kits for the inhibition of signaling by members of the Rho GTPase family. Specifically, the disclosure relates to methods, compositions and kits for the inhibition of RhoA and/or RhoC transcriptional signaling and action of the transcription co-factors MRTF-A and/or MRTF-B. The disclosure finds use in treatment of Rho-mediated disease states (e.g., tumor metastasis and fibrosis), Rho-mediated biological conditions, and in cell signaling research.
    Type: Application
    Filed: March 9, 2015
    Publication date: September 10, 2015
    Inventors: Scott D. Larsen, Jessica L. Bell, Richard Neubig, Kim Hutchings
  • PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
    Patent number: 9126959
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 8, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTION
    Publication number: 20150132352
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections (e.g., biofilms).
    Type: Application
    Filed: May 2, 2013
    Publication date: May 14, 2015
    Inventors: Hongmin Sun, Bryan Yestrepsky, David Ginsburg, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES
    Publication number: 20150051406
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Application
    Filed: October 30, 2014
    Publication date: February 19, 2015
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • Synthesis for thiazolidinedione compounds
    Patent number: 8946435
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 3, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • Synthesis for thiazolidinedione compounds
    Patent number: 8937182
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: January 20, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: James R. Zeller, Steven P. Tanis, Scott D. Larsen, Timothy Parker
  • Synthesis for Thiazolidinedione Compounds
    Publication number: 20140378687
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
    Patent number: 8912335
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: December 16, 2014
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • Synthesis for thiazolidinedione compounds
    Patent number: 8895748
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: November 25, 2014
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • THERAPEUTIC COMPOUNDS AND METHODS
    Publication number: 20140221412
    Abstract: The invention provides compounds of formula I: and salts thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating cancer using compounds of formula I.
    Type: Application
    Filed: August 30, 2012
    Publication date: August 7, 2014
    Applicants: WAYNE STATE UNIVERSITY, REGENTS OF THE UNIVERSITY OF MICHIGAN, DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Arun K. Rishi, Scott D. Larsen
  • NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS
    Publication number: 20140018542
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 16, 2014
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Timothy Parker, Robert C. Gadwood, Steven P. Tanis, Scott D. Larsen, James R. Zeller
  • SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS
    Publication number: 20130211092
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: August 9, 2011
    Publication date: August 15, 2013
    Applicant: METABOLIC SOLUTIONS DEVELOPMENT COMPANY LLC
    Inventors: Steven P. Tanis, Timothy Parker, Robert C. Gadwood, James R. Zeller, Gerald D. Artman, III, Scott D. Larsen
  • NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS
    Publication number: 20130211095
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: April 18, 2011
    Publication date: August 15, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Timothy Parker, Robert C. Gadwood, Steven P. Tanis, Scott D. Larsen, James R. Zeller
  • NOVEL SYNTHESIS FOR THIAZOLIDINEDIONE COMPOUNDS
    Publication number: 20130204004
    Abstract: The present invention provides novel methods for synthesizing PPAR? sparing compounds, e.g., thiazolidinediones, that are useful for preventing and/or treating metabolic disorders such as diabetes, obesity, hypertension, and inflammatory diseases.
    Type: Application
    Filed: April 18, 2011
    Publication date: August 8, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: James R. Zeller, Steven P. Tanis, Scott D. Larsen, Timothy Parker
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20130053350
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing neurodegenerative disorders.
    Type: Application
    Filed: December 15, 2010
    Publication date: February 28, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steve P. Tanis, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES
    Publication number: 20120322728
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.
    Type: Application
    Filed: December 15, 2010
    Publication date: December 20, 2012
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steven P. Tanis, Scott D. Larsen