Patents by Inventor Scott D. Rychnovsky

Scott D. Rychnovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mass spectromeiry-cleavable cross-linker
    Patent number: 11603352
    Abstract: Synthesis of a sulfoxide-containing homobifunctional cysteine-reactive mass spectrometry-cleavable cross-linker for mapping intra-protein interactions in a protein and inter-protein interactions in a protein complex is provided. Methods for mapping intra-protein interactions in a protein and inter-protein interactions in a protein complex and cross-linking mass spectrometry for identifying one or more cross-linked peptides using the cross-linker are provided.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: March 14, 2023
    Assignee: The Regents of the University of California
    Inventors: Lan Huang, Scott D. Rychnovsky
  • MASS SPECTROMETRY CLEAVABLE HETEROBIFUNCTIONAL PHOTOACTIVATED CROSS-LINKERS
    Publication number: 20220274963
    Abstract: The disclosure provides for mass spectrometry (MS)-cleavable heterobifunctional photoactivated cross-linkers. The MS-cleavable heterobifunctional photoactivated cross-linkers can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes.
    Type: Application
    Filed: February 24, 2022
    Publication date: September 1, 2022
    Inventors: Lan Huang, Scott D. Rychnovsky
  • MASS SPECTROMETRY-CLEAVABLE CROSS-LINKER
    Publication number: 20210253524
    Abstract: Synthesis of a sulfoxide-containing homobifunctional cysteine-reactive mass spectrometry-cleavable cross-linker for mapping intra-protein interactions in a protein and inter-protein interactions in a protein complex is provided. Methods for mapping intra-protein interactions in a protein and inter-protein interactions in a protein complex and cross-linking mass spectrometry for identifying one or more cross-linked peptides using the cross-linker are provided.
    Type: Application
    Filed: May 8, 2020
    Publication date: August 19, 2021
    Inventors: Lan Huang, Scott D. Rychnovsky
  • Mass spectrometry-cleavable cross-linker
    Patent number: 10697977
    Abstract: Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the novel MS-cleavable homobifunctional cross-linker that are complimentary to amine-reactive sulfoxide-containing MS-cleavable reagents.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: June 30, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lan Huang, Scott D. Rychnovsky, Clinton Yu, Eric James Novitsky, Craig Bryant Gutierrez
  • Mass spectrometry-cleavable cross-linking agents
    Patent number: 10393752
    Abstract: Provided herein is synthesis of novel mass spectrometry-cleavable cross-linking agents. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also provided are methods of mapping intra-protein interactions in proteins and inter-protein interactions in protein complexes.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: August 27, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Scott D. Rychnovsky, Lan Huang
  • MASS SPECTROMETRY-CLEAVABLE CROSS-LINKER
    Publication number: 20170350901
    Abstract: Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the novel MS-cleavable homobifunctional cross-linker that are complimentary to amine-reactive sulfoxide-containing MS-cleavable reagents.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 7, 2017
    Inventors: Lan Huang, Scott D. Rychnovsky, Clinton Yu, Eric James Novitsky, Craig Bryant Gutierrez
  • MASS SPECTROMETRY-CLEAVABLE CROSS-LINKING AGENTS
    Publication number: 20170082635
    Abstract: Provided herein is synthesis of novel mass spectrometry-cleavable cross-linking agents. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also provided are methods of mapping intra-protein interactions in proteins and inter-protein interactions in protein complexes.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 23, 2017
    Inventors: Scott D. Rychnovsky, Lan Huang
  • MASS SPECTROMETRY-CLEAVABLE CROSS-LINKING AGENTS TO FACILITATE STRUCTURAL ANALYSIS OF PROTEINS AND PROTEIN COMPLEXES, AND METHOD OF USING SAME
    Publication number: 20160245822
    Abstract: Novel cross-linking compounds that can be used in mass spectrometry, tandem mass spectrometry, and multi-stage tandem mass spectrometry to facilitate structural analysis of proteins and protein complexes are provided and have the formula: where X is an N-hydroxy-succinimidyl or similar heterocyclic group. Also provided is a method of mapping protein-protein interactions of protein complexes using various mass spectrometry techniques.
    Type: Application
    Filed: October 29, 2015
    Publication date: August 25, 2016
    Inventors: Scott D. Rychnovsky, Lan Huang