Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: A method and system for delivering audio and data files includes a data network and a voice network. A user station provided in communication with the data network receives data files. A telephone provided in communication with the voice network receives audio files. An application server in communication with the data network stores and executes applications programs which include audio features. An audio server in communication with the application server and the voice network is operative to dial a telephone, deliver a selected audio file to the telephone, or record and store an audio file.

Abstract: A computerized method and system for interactively simulating a plurality of telecommunications services operates in response to a user sending a message from his client computer across a data network to a server requesting to download on one of the service simulation programs. In response to the message from the client, the server provides the requested telecommunications service simulation program. The program provided by the server is downloaded and executed by the client. The downloaded program provides the user with an interaction experience representative of the selected one of the plurality of telecommunications services. This interaction experience may include additional communication between the service simulation program and the server. Additionally, the service simulation program provides guidance to the user in using and configuring both the service simulation program and, potentially, the actual telecommunications service to which the user has subscribed.