Abstract: The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

Abstract: The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.

Abstract: The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S.

Abstract: A method includes displaying keys of a keyboard in a keyboard area on a touch-sensitive display, at least one of the keys being associated with multiple letter characters, the keyboard area located adjacent to a first side of the touch-sensitive display, detecting a touch in a keyboard area of the touch-sensitive display, the touch being associated with a character input, detecting a gesture in a gesture input area of a touch-sensitive display, the gesture area located adjacent to a second side of the touch-sensitive display, the second side opposite to the first side; wherein the gesture is associated with a keyboard-related function at the processor and the keyboard-related function is operable on the character input or a next character input.

Abstract: A process for manufacturing a vitreous slag including rotating a cone about a vertical cone axis, the cone including an external shell having a lateral surface; cooling the lateral surface of the external shell; pouring molten slag onto the lateral surface of the cone to form a film of slag by gravity, which is solidified as it is entrained in rotation by the cone about the cone axis; and detaching pieces of the film from the lateral surface and removing solidified slag in the form of the pieces after the film has been entrained through between 0.6 and 0.9 revolutions of the cone, the molten slag being poured onto the lateral surface in a pouring zone and spreads to form a film over substantially the entire length of the lateral surface, preferably over between 75% and 95% of the length of the lateral surface.

Abstract: An example method includes detecting a hold touch and a release touch on a touch-sensitive display of an electronic device, wherein the hold touch and the release touch overlap at least partially in time, detecting release of the release touch, and in response to detecting the release of the release touch, displaying an editing control while the hold touch is detected. The editing control may include a virtual trackpad.

Abstract: The invention relates to a process for the synthesis of quaternized compounds of formula:

Abstract: The present invention relates to a process for the synthesis of a compound of formula I:

Abstract: An end-of-service life indicator for a sorbent filter includes a tube containing a noble metal nanoparticle film on an optically transparent substrate, the substrate being perpendicular to the axis of the tube. An opening in the tube adjacent to the film allows chemical vapor to accumulate in the tube and be absorbed by the film. A light source located at one end of the tube and a light detector at the other end determines the amount of light absorbed by the nanoparticle film due to exposure to chemical vapor. A signal from the light detector is applied to an electronic processor that determines attenuation of light by the film, and the processor is connected to an indicator to provide an indication of the exposure of the film to the vapor.

Abstract: An end-of-service life indicator for a sorbent filter includes a tube containing a noble metal nanoparticle film on an optically transparent substrate, the substrate being perpendicular to the axis of the tube. An opening in the tube adjacent to the film allows chemical vapor to accumulate in the tube and be absorbed by the film. A light source located at one end of the tube and a light detector at the other end determines the amount of light absorbed by the nanoparticle film due to exposure to chemical vapor. A signal from the light detector is applied to an electronic processor that determines attenuation of light by the film, and the processor is connected to an indicator to provide an indication of the exposure of the film to the vapor.

Abstract: A point vibration therapy device (“PVTD”) is designed to provide vibration therapy or stimulation to a user to alleviate stimming behavior caused by a sensory dysfunction. The PVTD includes a control system, a power system, and a vibration source system. The control system includes a control circuit, a housing, an I/O interface and inputs for a user to interact with the device, e.g., adjusting the frequency and duration of vibrations for optimal effect on the user. The power system includes a power source and charge management controller. The vibration source system includes a vibration source, a housing, power control connections, and an attachment device to attach to a user's body. The control system, power system, and vibration source system are all interconnected and may be contained in a singular or multiple housings.

Abstract: A preferred process for degassing a mold piece includes inserting the mold piece into an internal volume within a canister, sealing the internal volume, drawing a vacuum in the internal volume, and introducing into the internal volume a gaseous fluid suitable for degassing the mold piece.

Abstract: A preferred process for degassing a mold piece includes inserting the mold piece into an internal volume within a canister, sealing the internal volume, drawing a vacuum in the internal volume, and introducing into the internal volume a gaseous fluid suitable for degassing the mold piece.

Abstract: A drain stopper assembly for selectively opening and closing a drain located within a basin, tub or sink A lifting frame assembly is situated within the drain body supporting a stopper. The lifting frame is provided with first and second annular regions selectively coupled to a piston caused to extend within and withdrawn from the drain body. In a first orientation, the piston extends within a first annular region allowing the stopper and lifting frame to be removable from the drain body while in a second orientation, the piston extends within a second annular region which prevents the stopper and lifting aim from being removed from the drain body.

Abstract: A drain stopper assembly for selectively opening and closing a drain located within a basin, tub or sink. A clamp assembly is affixed to the sink's drain body pivotally supporting a magnet. A magnet or ferromagnetic material is appended to a lifting pedestal which in turn supports a stopper sized to selectively block the sink's drain collar.

Abstract: A high frequency flexure-based dynamometer for measuring vibrations to use in determining cutting forces in a tool is disclosed. The dynamometer device may operate within a pre-selected high frequency range while measuring cutting forces less than about 1 N. The dynamometer may include two coupled flexures that interact to produce vibration modes at the edge of a selected bandwidth of interest. These modes may produce a frequency response function within the desired frequency band that has a magnified response and is substantially constant. The dynamometer may include a workpiece mounted to one of the two flexures and a one or more precision accelerometers mounted to the first or second flexures. Finite element analysis may be used to optimize the flexure design.

Abstract: A unitary removable barrier for installation in a cylindrical water line to selectively block the water line to passage of water therethrough. The unitary removable barrier is composed of a single piece rubber body having at least one cylindrical section sized to receive upstream and downstream pipes of the water line. A unitary rubber planar disc molded with the cylindrical section is of a circular circumference and which completely blocks the water line but which is selectively removable from the cylindrical section thus removing the barrier to the passage of the waste through the line.

Abstract: A method for estimating a new content level in service agreements comprises defining a plurality of service requirement options associated with supply chain management processes and establishing a weight factor for each service requirement option. The service requirement options are provided to an interactive interface that allows a user to select one or more service requirement options to include in a desired supply chain management process. A plurality of user-selected service requirement options associated with the desired supply chain management process is received from the interactive interface. A new content level associated with the desired supply chain management process is determined and provided to one or more service requirement subscribers.

Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.