Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: An impact sensor for characterizing impact at a headpiece comprises: a flexible base; an acceleration sensor provided on the flexible base and configured to generate impact data; a control unit provided on the flexible base and configured to receive the impact data from the acceleration sensor; a power source provided on the flexible base and in communication with the acceleration sensor and the microcontroller; a communication module provided on the flexible base and configured to send impact data for processing; and a housing enclosing the flexible base, the acceleration sensor, the microcontroller and the power source, the housing shaped and constructed for mounting an interior surface of the headpiece such that it is flush with internal geometry of the headpiece.

Abstract: An impact sensor for characterizing impact at a headpiece comprises: a flexible base; an acceleration sensor provided on the flexible base and configured to generate impact data; a control unit provided on the flexible base and configured to receive the impact data from the acceleration sensor; a power source provided on the flexible base and in communication with the acceleration sensor and the microcontroller; a communication module provided on the flexible base and configured to send impact data for processing; and a housing enclosing the flexible base, the acceleration sensor, the microcontroller and the power source, the housing shaped and constructed for mounting an interior surface of the headpiece such that it is flush with internal geometry of the headpiece.

Abstract: Impact at a headpiece, for example a protective helmet, is characterized in part using an impact sensor including at least one acceleration switch positioned on the helmet. A microcontroller is configured to identify and store acceleration switch opening duration data based on the binary output values of the at least one acceleration switch. A processor at a portable electronic device receives the acceleration switch opening duration data and determines whether the experienced impact force is associated with an impact force magnitude that is within a predetermined head injury range of magnitude. An impact alert is generated when the impact force magnitude is within the predetermined head injury range of magnitude. In an embodiment, the portable electronic device displays a severity indication and an identifier of a person associated with the sensor that experienced impact.