Abstract: The slide staining device has a generally rectangular body which includes an upper rectangular frame and a lower rectangular frame. The upper rectangular frame and the lower rectangular frame are aligned and detachably connected together so that multiple microscope slides may be clamped therebetween for staining at the same time. Knobs with threaded bolts projecting therefrom fasten the upper and lower frames together. The lower rectangular frame includes a plurality of ridges to allow for liquid drainage during the washing stage of a staining procedure and a handle to facilitate manipulation of the device. The device of the present invention is designed to complement established and standard laboratory practice.