Patents by Inventor Scott E. Kern

Scott E. Kern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional assay for identification of loss-of-function mutations in genes
    Patent number: 9309511
    Abstract: Provided herein are compositions and methods for assaying the deleteriousness of putative loss-of-function mutations, especially in genes known to be or suspected of being tumor-suppressor genes. The invention includes syngeneic variance libraries and methods of construction and use of syngeneic variance libraries.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: April 12, 2016
    Assignee: The Johns Hopkins University
    Inventors: Scott E. Kern, Eike Gallmeier, Tomas Hucl
  • FUNCTIONAL ASSAY FOR INDENTIFICATION OF LOSS-OF-FUNCTION MUTATIONS IN GENES
    Publication number: 20100305001
    Abstract: Provided herein are compositions and methods for assaying the deleteriousness of putative loss-of-function mutations, especially in genes known to be or suspected of being tumor-suppressor genes. The invention includes syngeneic variance libraries and methods of construction and use of syngeneic variance libraries.
    Type: Application
    Filed: August 28, 2008
    Publication date: December 2, 2010
    Applicant: The Johns Hopkins University
    Inventors: Scott E. Kern, Eike Gallmeier, Tomas Hucl
  • Conductive media for electrophoresis
    Patent number: 7811437
    Abstract: A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate mitigate the “runaway” positive feedback heating loop produced by conventional media containing biological amine buffers and permit improved DNA electrophoresis under the conditions of low salt concentration. These media serve well in ultra-fast DNA electrophoresis and in high-resolution separations of RNA and DNA fragments.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: October 12, 2010
    Assignee: Faster Better Media LLC
    Inventors: Scott E. Kern, Jonathan R. Brody
  • Conductive media for electrophoresis
    Patent number: 7163610
    Abstract: A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate mitigate the “runaway” positive feedback heating loop produced by conventional media containing biological amine buffers and permit improved DNA electrophoresis under the conditions of low salt concentration. These media serve well in ultra-fast DNA electrophoresis and in high-resolution separations of RNA and DNA fragments.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: January 16, 2007
    Assignee: Faster Better Media LLC
    Inventors: Scott E. Kern, Jonathan R. Brody
  • Methods and reagents for facilitating transcription
    Patent number: 6544957
    Abstract: A previously unknown histone acetylase inhibitor, 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, termed “scriptaid,” can be used to enhance transcription. Scriptaid can be added to transactivation assays, or can be used, for example, to increase production of therapeutic polypeptides in vitro and in vivo.
    Type: Grant
    Filed: January 3, 2001
    Date of Patent: April 8, 2003
    Assignee: The Johns Hopkins University
    Inventors: Scott E. Kern, Gloria Su
  • Methods and reagents for facilitating transcription
    Publication number: 20010031722
    Abstract: A previously unknown histone acetylase inhibitor, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, termed “scriptaid,” can be used to enhance transcription. Scriptaid can be added to transactivation assays, or can be used, for example, to increase production of therapeutic polypeptides in vitro and in vivo.
    Type: Application
    Filed: January 3, 2001
    Publication date: October 18, 2001
    Inventors: Scott E. Kern, Gloria Su
  • Tumor suppressor gene, DPC4
    Patent number: 5955292
    Abstract: Polynucleotide and polypeptide sequences encoding a novel tumor suppressor gene, DPC4, are provided. Also included is a method for detecting a cell proliferative disorder associated with DPC4. DPC4 is a marker which can be used diagnostically, prognostically and therapeutically over the course of disorders associated with DPC4.
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: September 21, 1999
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Scott E. Kern, Stephan A. Hahn
  • DPC4 polypeptide
    Patent number: 5814457
    Abstract: Polynucleotide and polypeptide sequences encoding a novel tumor suppressor gene, DPC4, are provided. Also included is a method for detecting a cell proliferative disorder associated with DPC4. DPC4 is a marker which can be used diagnostically, prognostically and therapeutically over the course of disorders associated with DPC4.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: September 29, 1998
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Scott E. Kern, Stephan A. Hahn
  • Tumor suppressor gene, DPC4
    Patent number: 5712097
    Abstract: Polynucleotide and polypeptide sequences encoding a novel tumor suppressor gene, DPC4, are provided. Also included is a method for detecting a cell proliferative disorder associated with DPC4. DPC4 is a marker which can be used diagnostically, prognostically and therapeutically over the course of disorders associated with DPC4.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: January 27, 1998
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Scott E. Kern, Stephan A. Hahn