Abstract: Systems and methods for pressure differential measurement and hemodynamic response assessment in vascular lumens are disclosed. Systems include catheter-based devices with variable flow restriction to create a controlled variable pressure differential (?P) within the coronary sinus. Methods are disclosed that allow a range of pressure changes to be mapped to a range of flow restriction diameters on a patient-specific basis as well as mapped to clinically measurable indicators of restriction/pressure change effect on hemodynamic and cardiac response.

Abstract: A needle bending assembly configured to at least temporarily contain a needle can include a first housing section, a second housing section, and a coupling element coupled between the first housing section and the second housing section. The first housing section defines a first cavity configured to at least temporarily contain a first section of the needle. The second housing section defines a second cavity configured to at least temporarily contain a second section of the needle forming a distal tip. The coupling element is configured such that when the needle is contained within the housing sections, movement of the second housing section relative to the first housing section results in a bending of the needle at a location corresponding to the coupling element.

Abstract: A needle bending assembly configured to at least temporarily contain a needle can include a first housing section, a second housing section, and a coupling element coupled between the first housing section and the second housing section. The first housing section defines a first cavity configured to at least temporarily contain a first section of the needle. The second housing section defines a second cavity configured to at least temporarily contain a second section of the needle forming a distal tip. The coupling element is configured such that when the needle is contained within the housing sections, movement of the second housing section relative to the first housing section results in a bending of the needle at a location corresponding to the coupling element.

Abstract: A graft tensioning tool includes an elongate frame having a proximal end, a distal end, and an axial passage extending therethrough. The distal end is configured to detachably engage a tunnel ring at an entrance to a tunnel in bone, and the frame includes a first suture puller and a second suture puller. Each suture puller detachably engages a length of suture emerging through the attached to suture and/or a soft tissue implant in the bone tunnel. A tensioner on the elongate frame displaces the suture pullers in a proximal direction to apply a controlled tension to the suture lengths and/or implant. A tension gauge measures tension applied to the suture pullers, and a locking tool is configured to engage the suture lock through the axial passage of the frame, allowing a user to fix the suture ends to bone when a target tension is attained.

Abstract: A controller is capable of controlling an asset or target in physical and/or virtual three-dimensional space using a single hand by generating control inputs in four or more degrees of freedom while also limiting cross-coupling (unintended motions). The controller includes a first control member is configured to be gripped in a user's single, second control member is disposed on or near a top end of the first member movable with at least one degree of freedom independently of the movement of the first control member, and a third control member positioned on the first member for displacement by one or more digits of the user's single hand and coupled with the second member to move in opposition to movement of the second control member.

Abstract: A controller includes a first control member movable with one or two degree(s) of freedom (DoF) a second control member coupled to the first control member and movable with three independent DoFs and a third control member coupled to the first and the second control members, the third control member movable with one DoF, which is being one of the three DoFs of the second control member in the set, and providing a third control input, wherein the first, the second, and the third control members are configured to be operated by a user's single hand. Further, a forearm brace for attaching to a forearm of a user and a controller is used to support the user's forearm when the user operates the controller. Additionally, the controller includes vibration haptic motors for provide haptic alerts to the user based on position data and/or orientation data associated with a target object.

Abstract: A controller includes a first control member movable with one or two degree(s) of freedom (DoF) a second control member coupled to the first control member and movable with three independent DoFs and a third control member coupled to the first and the second control members, the third control member movable with one DoF, which is being one of the three DoFs of the second control member in the set, and providing a third control input, wherein the first, the second, and the third control members are configured to be operated by a user's single hand. Further, a forearm brace for attaching to a forearm of a user and a controller is used to support the user's forearm when the user operates the controller. Additionally, the controller includes vibration haptic motors for provide haptic alerts to the user based on position data and/or orientation data associated with a target object.

Abstract: A system used to entrap clots in arteries, such as cerebral arteries, between the artery wall and an external surface of a stent to provide restoration of blood flow therethrough that includes a stent forming an annular wall that defines a set of openings, and an expansion member extendable through the stent to place a distal portion thereof distal to the stent. The stent is advanced into a clot disposed within a vessel and transitioned to an expanded configuration such that the annular wall engages the clot. The expansion member extends through the stent and is transitioned to an expanded state such that a diameter of the distal portion is greater than a diameter of a proximal portion thereof. The expanded distal portion is sized to fill a portion of the vessel to prevent clot fragments from flowing distal to the expansion member.

Abstract: A gimbal support that senses rotational displacement and provides haptic feedback in one, two or three dimensions of a manually-operated control member used to generate control inputs using a single hand while also limiting cross-coupling.

Abstract: A device for occluding a patient's left atrial appendage (LAA) device includes a self-expanding closure disc and an anchor. The self-expanding closure disc has an atrial side, an appendage side, and a peripheral edge configured to engage tissue on both an atrial side and an appendage side of an opening between the left atrium and the left atrial appendage. The self-expanding anchor extends from the appendage side of the self-expanding closure disc, and an annular sealing skirt extends about at least a portion of the appendage side of the self-expanding closure disc. the annular sealing skirt is more compliant than the self-expanding closure disc to seal over the left appendage side of the opening after implantation of the device in the LAA.

Abstract: The present disclosure relates generally to control systems, and in particular apparatus, methods, and systems for controlling flights remotely or onboard the vehicle. More specifically, the present disclosure describes embodiments of a control system that allows a user to control the motion of a control target in or along one or more degrees of freedom using a single controller.

Abstract: A controller is capable of controlling an asset or target in physical and/or virtual three-dimensional space using a single hand by generating control inputs in four or more degrees of freedom while also limiting cross-coupling (unintended motions). The controller includes a first control member is configured to be gripped in a user's single, second control member is disposed on or near a top end of the first member movable with at least one degree of freedom independently of the movement of the first control member, and a third control member positioned on the first member for displacement by one or more digits of the user's single hand and coupled with the second member to move in opposition to movement of the second control member.

Abstract: A gimbal support that senses rotational displacement and provides haptic feedback in one, two or three dimensions of a manually-operated control member used to generate control inputs using a single hand while also limiting cross-coupling.

Abstract: The present disclosure relates generally to control systems, and in particular apparatus, methods, and systems for controlling flights remotely or onboard the vehicle. More specifically, the present disclosure describes embodiments of a control system that allows a user to control the motion of a target in or along one or more degrees of freedom using a single controller. The control system described herein also include mechanisms that permit the conversion of user intent into discrete 3-D motions with tactile feedback relative to the null command.

Abstract: Disclosed is a controller including a first control member, a second control member that extends from a portion of the first control member, and a controller processor that is operable to produce a rotational movement output signal in response to movement of the first control member, and a translational movement output signal in response to movement of the second control member relative to the first control member. The rotational movement output signal may be any of a pitch movement output signal, a yaw movement output signal, and a roll movement output signal, and the translational movement output signal may be any of an x-axis movement output signal, a y-axis movement output signal, and a z-axis movement output signal.

Abstract: Disclosed is a controller including a first control member, a second control member that extends from a portion of the first control member, and a controller processor that is operable to produce a rotational movement output signal in response to movement of the first control member, and a translational movement output signal in response to movement of the second control member relative to the first control member. The rotational movement output signal may be any of a pitch movement output signal, a yaw movement output signal, and a roll movement output signal, and the translational movement output signal may be any of an x-axis movement output signal, a y-axis movement output signal, and a z-axis movement output signal.

Abstract: A device includes a body defining a respiration passage in fluidic communication with a filter fitting disposed on a first end of the body and a mask fitting disposed on a second end of the body, and a treatment passage in fluidic communication with the mask fitting. A treatment fitting is disposed on the body and is coupleable to a treatment source such that a seal in the treatment fitting transitions from a closed state to an open state to allow fluidic communication between the treatment source and the treatment passage. The device configured to permit (i) inhalation air and/or exhaled breath to be drawn and/or expelled through the filter fitting, the respiration passage, and the mask fitting and (ii) a respiratory therapeutic to be drawn from the treatment source coupled to the treatment fitting, through the treatment passage, and through the mask fitting.

Abstract: A hand controller that includes a control member mounted on a hand held base for commanding a remote vehicle or movement of a virtual object within a virtual environment includes an input device mounted for generating tilt commands for a sensor mounted on the remote vehicle or the virtual object, the input device being located on a front of the base and oriented to be displaced up and down to tilt the sensor or the virtual point of view when the base is held during operation.

Abstract: A hand controller for commanding or controlling a target, such as a remote vehicle or a virtual target, includes a display mounted on a free end of a joystick for indicating graphically a direction of the remote vehicle from the hand controller and an orientation of the target relative to the hand controller's frame of reference, based on the location and orientation of the target received by the hand controller from the target and the location and orientation of the hand controller.

Abstract: A gimbal support that senses rotational displacement and provides haptic feedback in one, two or three dimensions of a manually-operated control member used to generate control inputs using a single hand while also limiting cross-coupling.