Patents by Inventor Scott Eliot Kern

Scott Eliot Kern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human Smad3 and Smad4 are sequence-specific transcription activators
    Patent number: 6100032
    Abstract: Two human Smad proteins (Smad3 and Smad4) specifically recognize an identical 8 bp palindromic sequence (GTCTAGAC) (SEQ ID NO: 1). Tandem repeats of this palindrome confer striking TGF-.beta. responsiveness to a minimal promoter. This responsiveness is abrogated by targeted deletion of the cellular Smad4 gene. DNA molecules comprising the 8 bp palindromic sequence can be used in assays for drug screening and diagnostically.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: August 8, 2000
    Assignee: Johns Hopkins University
    Inventors: Scott Eliot Kern, Leigh Zawel, Jia Le Dai, Bert Vogelstein, Kenneth W. Kinzler