Abstract: An ocular insert containing one or more reporters is described. Each reporter is bound to the ocular insert via a peptide sequence selectively cleaved by a targeted protease. Each peptide sequence is hydrolytically stable in tear fluid for at least 30 minutes in absence of the targeted protease. A biocompatible fluid container containing one or more sensors is described. Each sensor contains reporters bound to one or more surfaces contacting the biocompatible fluid and released from the surface when exposed to specific pathogens. A wearable ocular insert directly capturing biomarkers for ocular disease is described. The biomarkers are detected either once released from the ocular insert or directly onto the surface of the ocular insert. A lateral flow device comprising a modified Schirmer's strip and at least one test region is described. The test region comprises immobilized peptides, antibodies or aptamers, and a lateral flow device weighing no more than 4 g.

Abstract: A computer system for dynamically controlling a thermoset printer (100) may comprise one or more processors (210) and one or more computer-readable media having stored thereon executable instructions that when executed by the one or more processors, configure the computer system to perform various acts. The computer system may receive a thermoset printing data packet that comprises an indication of a desired final material property of the target object to be printed. The computer system may also receive an indication of one or more thermoset materials (250a,250b) that are available to the thermoset three-dimensional printer and access a material attribute dataset that describes different material properties. Based upon the material attribute dataset, the computer system may determine a particular mixture configuration for the one or more thermoset materials and generate a command to cause the thermoset three-dimensional printer to implement the particular mixture configuration.

Abstract: A computer system (110) for controlling a thermoset printer (100) to create desired material attributes comprises one or more processors (210) and one or more computer-readable media (220) having stored thereon executable instructions that when executed by the one or more processors configure the computer system to perform various acts. The computer system may receive an indication of one or more thermoset materials that are to be used by the thermoset printer (100) to print a target object (120). The computer system (110) may also access a material attribute dataset that describes different material properties of the one or more thermoset materials during printing. Based upon the material attribute dataset, the computer system determines a particular extrusion configuration for the one or more thermoset materials and generates a command to cause the thermoset printer to implement the particular extrusion configuration while printing the target object (120).

Abstract: A computer system for dynamically controlling a three-dimensional printer may comprise one or more processors and one or more computer-readable media having stored thereon executable instructions that, when executed by the one or more processors, configure the computer system to perform various acts. The computer system may receive an indication to cause a three-dimensional printer to print a non-planar surface. Additionally, the computer system may calculate multiple different bead sizes for creating the non-planar surface using components of the three-dimensional printer. The computer system may also create a command to generate the multiple different bead sizes at locations within a printing area.

Abstract: An anti-fogging facemask for preventing fogging of the wearer's glasses or goggles is described herein. The anti-fogging facemask includes an outer facemask and an inner facemask. The inner facemask is attached to the outer facemask. The inner facemask provides a barrier to prevent exhaled air from traveling through the upper end of the facemask. The inner facemask directs exhaled air downwards. The outer facemask forms a seal at an upper portion of the wearer's nose. The facemask may be configured to serve as a CO2 concentrating mask for temporary relief of allergic rhinitis symptoms.

Abstract: An anti-fogging facemask for preventing fogging of the wearer's glasses or goggles may be described herein. The anti-fogging facemask include an outer facemask and an inner facemask. The inner facemask is attached to the outer facemask. The inner facemask provides a barrier to prevent exhaled air from traveling through the upper end of the facemask. The inner facemask directs exhaled air downwards. The outer facemask forms a seal at an upper portion of the wearer's nose.

Abstract: An ocular device for insertion into the eye (for example, into a lacrimal punctum or a conjunctival sac) are described herein. The ocular device may continuously capture specific analytes from tear fluid. Several embodiments of the ocular device may have one or more open channels and pores that enable tears to drain naturally through while capturing specific analytes. A mechanism of detecting analytes in bodily fluids using materials comprised of DNAzymes and/or aptamers are described herein. Aptamers are oligonucleotide or peptide molecules that bind to a specific target molecule. DNAzymes are designed to catalyze a number of biological reactions (i.e., RNA cleavage, DNA cleavage, ligation, or phosphorylation reactions). A number of ways an ocular insert may capture analytes in tear fluid in vivo for subsequent in vitro analysis are described herein. Additionally, a specific mechanism for colorimetric detection of analytes using aptamer- and/or DNAzyme-crosslinked hydrogels are described herein.

Abstract: A method for delivering catheters, and stents composed of soft, compliant polymers through anatomical passages. These devices have a bulbous anchorage end with a diameter greater than the rest of the catheter. To facilitate implant and delivery a pusher catheter or sheath with an internal lumen larger than the outer diameter of the catheter but smaller than the outer diameter of the bulbous anchorage end. The distal end of pusher catheter or the sheath physically engages the proximal end of the bulbous anchorage end and applies an axial force to coaxially advance the catheter over a guidewire though anatomical passages. This method allows a physician to move the catheter to an anatomical site without the device exhibiting buckling due to axial force applied. Similarly, this delivery method will allow more force to be applied to the distal end of the catheter diminishing the likelihood of buckling.

Abstract: The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.

Abstract: Devices, systems and methods for providing energy to treat large areas of tissue. Several embodiments of the devices control resistance or other parameters to provide substantially uniform current density along a length of tissue with reduced edge effects.

Abstract: The present invention relates generally a manufacturing process which results in a completely hydrogel polymer device that maintains lumen patency which allows for numerous applications. Catheters and stents are particular examples, and their composition, mechanical characteristics, and the significantly unique ability to conduct and allow fluids to pass from one end to the other without physiological rejection, inflammation, or manifestation of complications due to implant or otherwise undesirable outcomes when used for ambulatory and or therapeutic interventions is the purpose of the invention.