Abstract: Apparatus and methods for prime field modular reduction are described. As an example, a custom modular reduction digital circuit for reducing an n-bit integer based on a modulus, where the modulus comprises a k-bit integer for use with a cryptographic algorithm, is described. The custom modular reduction digital circuit includes a first circuit to generate at least two partial results by processing: (1) k lower order significant bits of the n-bit integer and (2) at least a subset of bits for congruent representations corresponding to any n-k higher order bits of the n-bit integer that are higher in significance than the most significant bit of the k-bit integer. The custom modular reduction digital circuit further includes a second circuit to process the at least two partial results, output by the first circuit, to generate a reduced version of the n-bit integer for use with the cryptographic algorithm.

Abstract: The present disclosure provides novel synthetic nucleic acids and recombinant adeno-associated virus (rAAV) comprising the same, as well as methods of their use in the treatment of muscular dystrophies associated with a dystrophin mutation. Also provided are pharmaceutical compositions comprising a novel synthetic nucleic acid or rAAV of the invention, and a pharmaceutically acceptable carrier or excipient. Pharmaceutical compositions comprising an rAAV of the invention may be useful in gene therapy for the treatment of dystrophin-associated muscular dystrophies, such as Duchenne muscular dystrophy (DVD). Becker muscular dystrophy (BMD), and X-linked cardiomyopathy.

Abstract: This application relates to recombinant adeno-associated virus (rAAV) packaging and/or producer cell lines which have been engineered to reduce expression and/or activity of one or more genes and/or proteins to increase rAAV titers. The methods of generating the engineered cell lines have also been described herein.

Abstract: The present disclosure provides compositions including recombinant nucleic acid constructs, vectors, and host cells, and methods of their use for reducing reverse packaging of cap and/or rep DMA sequences in the production of recombinant adeno-associated vims (rAAV). Also provided are pharmaceutical compositions comprising an rAAV produced from a composition or method of the invention and a pharmaceutically acceptable carrier or excipient. These pharmaceutical compositions may be useful in gene therapy for the prevention or treatment of a disease, condition, or disorder in a subject.

Abstract: A method for secure key exchange. The method comprises receiving a request to certify a key from a communication partner at an interface between an access and tamper resistant circuit block and exposed circuitry. Within the access and tamper resistant circuit block, a first random private key is generated. A corresponding public key of the first random private key is derived, and a cryptographic digest of the public key and attributes associated with the first random private key is generated. The generated cryptographic digest is signed using a second random private key that has been designated for signing by one or more associated attributes. The public key and the signature are then sent to the communication partner via the interface.

Abstract: This present disclosure provides recombinant adeno-associated virus (rAAV) and methods of their use in gene therapy for treating propionic acidemia (PA). Also provided are pharmaceutical compositions comprising a rAAV of the invention and a pharmaceutically acceptable carrier or excipient. These pharmaceutical compositions may be useful in gene therapy for the treatment of PA caused by a mutation in propionyl-CoA carboxylase ?-subunit (PCCA) or a mutation in propionyl-CoA carboxylase ?-subunit (PCCB).

Abstract: A method for secure key exchange. The method comprises receiving a request to certify a key from a communication partner at an interface between an access and tamper resistant circuit block and exposed circuitry. Within the access and tamper resistant circuit block, a first random private key is generated. A corresponding public key of the first random private key is derived, and a cryptographic digest of the public key and attributes associated with the first random private key is generated. The generated cryptographic digest is signed using a second random private key that has been designated for signing by one or more associated attributes. The public key and the signature are then sent to the communication partner via the interface.

Abstract: This present disclosure provides adeno-associated viral vectors, recombinant adeno-associated vims (rAAV), and methods of their use in gene therapy for treating CDKL5 deficiency disorder (CDD). Also provided are pharmaceutical compositions comprising an rAAV of the invention and a pharmaceutically acceptable carrier or excipient. These pharmaceutical compositions may be useful in gene therapy for the treatment of CDD caused by mutations in CDKL.

Abstract: A method for secure key exchange. The method comprises receiving a request to certify a key from a communication partner at an interface between an access and tamper resistant circuit block and exposed circuitry. Within the access and tamper resistant circuit block, a first random private key is generated. A corresponding public key of the first random private key is derived, and a cryptographic digest of the public key and attributes associated with the first random private key is generated. The generated cryptographic digest is signed using a second random private key that has been designated for signing by one or more associated attributes. The public key and the signature are then sent to the communication partner via the interface.

Abstract: Disclosed is a cryptographic key management system implemented in access and tamper resistant circuitry. The circuitry includes processing circuitry to perform cryptographic processing based cryptographic keys. Cryptographic key registers include key portions and attribute portions. An interface receives commands from exposed circuitry that controls the processing circuitry to perform cryptographic processing based on the keys and associated attributes. The attributes indicate what operations may be performed on, or using, the associated keys. of the associated keys. The attributes indicate intended uses of the keys.

Abstract: Systems and methods may include software development tools that allow for planning hybrid projects performed according to a combination of project development models. A processor may be operatively coupled to a memory. The processor may determine a target application of an enterprise service. The processor may determine a backlog associated with the target application, wherein the backlog comprises one or more tasks, one or more stories, or any combination thereof. The processor may generate a hybrid project from the backlog comprising a waterfall phase having at least one task and an agile phase having at least one story.

Abstract: This present disclosure provides adeno-associated viral vectors, recombinant adeno-associated virus (rAAV), and methods of their use in gene therapy for treating propionic acidemia (PA). Also provided are pharmaceutical compositions comprising a recombinant adeno-associated virus of the invention and a pharmaceutically acceptable carrier or excipient. These pharmaceutical (compositions may be useful in gene therapy for the treatment of PA caused by mutations in propionyl-CoA carboxylase ?-subunit (PCCA) or mutations in propionyl-CoA carboxylase ?-subunit (PCCB).

Abstract: Systems and methods are related to timesheet entries in a unified view. The system may include a processor that receives a selection of a task from a list of tasks, such as project tasks, scrum tasks, incidents, or problems, displayed in a first portion of a unified view. The processor generates a timesheet entry based on the task selected. The processor displays the timesheet entry in a list of timesheet entries in a second portion of the unified view. The processor receives an input that indicates an amount of time on the at least one day of the timesheet entry. The processor determines a total amount of time based on the amount of time entered on the timesheet entry on the at least one day. The processor displays the total amount of time entered in each day in a third portion of the unified view.

Abstract: Systems and methods are related to timesheet entries in a unified view. The system may include a processor that receives a selection of a task from a list of tasks, such as project tasks, scrum tasks, incidents, or problems, displayed in a first portion of a unified view. The processor generates a timesheet entry based on the task selected. The processor displays the timesheet entry in a list of timesheet entries in a second portion of the unified view. The processor receives an input that indicates an amount of time on the at least one day of the timesheet entry. The processor determines a total amount of time based on the amount of time entered on the timesheet entry on the at least one day. The processor displays the total amount of time entered in each day in a third portion of the unified view.

Abstract: Systems and methods may include software development tools that allow for planning hybrid projects performed according to a combination of project development models. A processor may be operatively coupled to a memory. The processor may determine a target application of an enterprise service. The processor may determine a backlog associated with the target application, wherein the backlog comprises one or more tasks, one or more stories, or any combination thereof. The processor may generate a hybrid project from the backlog comprising a waterfall phase having at least one task and an agile phase having at least one story.

Abstract: Systems and methods may include software development tools that allow for planning hybrid projects performed according to a combination of project development models. A processor may be operatively coupled to a memory. The processor may determine a target application of an enterprise service. The processor may determine a backlog associated with the target application, wherein the backlog comprises one or more tasks, one or more stories, or any combination thereof. The processor may generate a hybrid project from the backlog comprising a waterfall phase having at least one task and an agile phase having at least one story.

Abstract: Systems and methods are related to a global ranking for a unified list of tasks. From a plurality of work projects each having one or more tasks, a processor may receive a first set of selections of at least two work projects for generating a work backlog having a unified list of tasks. The processor may generate a list of potential tasks to include in the work backlog from the selected work projects. The processor may receive a second set of selections of one or more of the potential tasks to include in the work backlog. The processor may send signals to display the unified list of tasks of the work backlog based on the potential tasks selected. The unified list of tasks comprises at least two types of tasks from two different work projects having disparate priority metrics.

Abstract: A patient monitoring system includes an identification transmitter that transmits an identification signal associated with a patient and a location tracking system having a plurality of identification receivers arranged in a care facility that receive the identification signal from the identification transmitter, wherein the location tracking system determines a patient location within a care facility based on a location of receipt of the identification signal. The patient monitoring system further includes an activity tracking module executable to receive at least one activity threshold for the patient and the patient location, and to determine a patient activity indicator based on the patient location. The activity tracking module is further executable to generate an activity alert based on a comparison between the patient activity indicator and the activity threshold.

Abstract: Systems and methods may include software development tools that allow for planning hybrid projects performed according to a combination of project development models. A processor may be operatively coupled to a memory. The processor may determine a target application of an enterprise service. The processor may determine a backlog associated with the target application, wherein the backlog comprises one or more tasks, one or more stories, or any combination thereof. The processor may generate a hybrid project from the backlog comprising a waterfall phase having at least one task and an agile phase having at least one story.

Abstract: Disclosed is a cryptographic key management system implemented in access and tamper resistant circuitry. The circuitry includes processing circuitry to perform cryptographic processing based cryptographic keys. Cryptographic key registers include key portions and attribute portions. An interface receives commands from exposed circuitry that controls the processing circuitry to perform cryptographic processing based on the keys and associated attributes. The attributes indicate what operations may be performed on, or using, the associated keys. of the associated keys. The attributes indicate intended uses of the keys.