Abstract: A paper clip for fastening two or more sheets of paper together, the paper clip formed of two substantially U-shaped clamping members, having elongate members formed in loops with a single loop facing in one direction and a pair of nesting loops facing in the opposite direction, the paper clip further including an elongate member, wherein a portion of the elongate member is bent to form a substantially C shape and another elongate member having a tip projecting at an angle into the open center of the C shape, the projecting tip for piercing through the papers at a common point for securely stapling the papers together, such that the papers are held together via the projecting tip in combination with the paper clip.

Abstract: Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types may be used to retain stationary phase material within columns. A fluidic distribution network may be used to distribute stationary phase material and/or mobile phase solvents to multiple columns. Separation devices, including microfluidic embodiments, may be fabricated with various materials including polymers. Multi-column fabrication and separation methods are provided.

Abstract: Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.

Abstract: Systems and methods for performing multiple parallel chromatographic separations are provided. Microfluidic cartridges containing multiple separation columns allow multiple separations to be performed in a limited space by a single instrument containing high-pressure pumps and analyte detectors. The use of pressure fit interfaces allows the microfluidic cartridges to easily be removed and replaced within the instrument, either manually or robotically.