Abstract: An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.

Abstract: A needle injector includes a syringe body along with a needle disposed in fluid communication with said syringe body. A plunger including a plunger head is disposed within said syringe body and a saline solution is disposed in the syringe body. A dried medicament is disposed on an inside surface of the syringe body in a position enabling movement of the plunger head in the syringe body to cause reconstitution of the medicament saline solution and ejection of the reconstituted medicament through the needle.

Abstract: A needleless microprotrusion system for infusion of a medicament into a patient includes a plurality of microprotrusions having a length sufficient to penetrate a stratum corneum of the patient. A chemodenervating agent is disposed for delivery by the microprotrusions and a substrate is provided for supporting the microprotrusions and conforming the microprotrusions to a patient's palm in order to enable uniform penetration of the microprotrusions into the corneum.

Abstract: A needleless microprotrusion method for infusion of a medicament into a patient includes disposing a substrate plurality of microprotrusions onto a patients' palm. A chemodenervating agent is disposed for delivery by the microprotrusions and the substrate supports and conforms the microprotrusions to the patients' palm in order to enable uniform penetration of the microprotrusions into the corneum.

Abstract: A needleless injector generally includes a barrel having a proximal and a distal end and a bore therethrough along with an injection head disposed at the barrel distal end in fluid communication with the bore; an energy source is disposed at the barrel proximal end and a bolt may be disposed in said bore for reciprocating movement therein, from a first position to a second position for drawing medicament into the bore, the bolt being fitted in the bore in order to force medicament through the injection head upon movement of the bolt from the second to the first position. A mechanism is provided for activating the energy source in order to operate the bolt.

Abstract: A plastic container closure includes a bottle having an open end with a circumferential bottle shoulder and a tip insertable into the bottle opened end with a tip shoulder overlaying the bottle shoulder. The compressible seal ring is provided and disposed between the bottle shoulder and the tip shoulder and a tip-covering cap engagable with the bottle and the cap compressed to the seal.

Abstract: A terminally sterilizable container includes a polypropylene bottle having a body with a manually squeezable sidewall and a thickness preventing water loss. The bottle body includes shoulders for providing autoclave produced pressure distribution and deformation resistance along with an elongated tips outfitted to a neck of the body and having a lumen therethrough with a drop dispensing orifice. A cap enclosed the elongated tip and includes enclosed with a nub for sealing the orifice to prevent autoclave produced pressure leaks.

Abstract: A needleless microprotrusion system for infusion of a medicament into a patient includes a plurality of microprotrusions having a length sufficient to penetrate a stratum corneum of the patient. A chemodenervating agent is disposed in a microprotrusions in a substrate is provided for supporting the microprotrusion and conforming the microprotrusions to a selected patient body part in order to enable uniform penetration of the microprotrusions into the corneum.

Abstract: A controlled drop dispensing tip for a squeeze bottle includes a nozzle assembly having a needle with a lumen therethrough for flow of liquid formulation and an orifice in fluid communication with a lumen. A shroud is provided and disposed about the needle in order to prevent inadvertent contact of the needle with a users eye. The shroud may partially surround the needle and include an open end with a circumferential opening enabling passage of droplets therepast.

Abstract: Controlled drop dispensing tube apparatus includes a tube for containing a medicament, a dispensing tip having an aperture in fluid communication with the tube, a collapsible shell for containing the tube, and a mechanism disposed in the shell for comprising the tube in order to force medicament from the tube and through the dispensing tip upon collapsing of the shell.

Abstract: A container system includes a squeeze bottle of a specific volume having a neck with an open end and a medicament disposed within the bottle. A tip is provided which is insertable into the open end of the squeezable bottle and includes an internal tapered nozzle with the nozzle having increased diameter toward a tip opening. A cap is provided for removable attachment to the bottleneck for sealing the tip opening and a shoulder formed in the bottle proximate the neck and disposed at an angle is provided in order to enhance bubbless flow of the medicament to the nozzle and facilitate tamper proof sealing of the cap.

Abstract: A controlled drop dispensing tip includes a body suitable for attachment to a dispensing bottle and a nozzle having a lumen therethrough for flow of liquid formulation. An orifice is provided in the nozzle which is in fluid communication with the lumen therethrough for formulation of droplets. The nozzle is formed from a material enabling uniform droplet dispensment of the liquid formulation independent of downward angular orientation of the tip.

Abstract: An apparatus and methods for delivering ocular implants or microimplants. The apparatus is ergonomically designed for ease of use, and a simple manual depression of an actuator produces proportional movement of a linkage causing the implant or microimplant to be ejected through a cannula disposed at the desired location in the eye. Small gauge cannulas are provided for self-sealing methods of delivery.