Abstract: An intravesical intermittent instillation catheter includes a tube containing a urinary lumen and an instillation lumen. The proximal end has a set of drainage eyelets, formed in a wall of the tube, that are in communication with the urinary lumen as well as a set of instillation eyelets, formed at a tip of the proximal end, in communication with the instillation lumen. A sheath is slidably mounted to surround the tube and having first and second axial positions wherein, in the first position, the drainage eyelets are exposed and, in the second position, the drainage eyelets are covered by the proximal end of the sheath.

Abstract: Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein said tannins are optionally bound to an anti-cancer agent and/or liposomes containing an anti-cancer agent, together with compositions related thereto.

Abstract: Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein said tannins are bound to an anti-cancer agent and/or liposomes containing an anti-cancer agent, together with compositions related thereto.

Abstract: A catheter for insertion into a body cavity of a subject (such as the urinary bladder), and having a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter; a closure member mountable for sliding movement within the drainage tube between a first position such that said drainage opening is in fluid communication with the drainage outlet and a second position wherein the closure member blocks fluid communication between the drainage opening and the outlet port; and an actuator, operable from the proximal end of the catheter, to move the closure member between the first and second positions. The closure member can include a second tube, sliding within the drainage tube, or a slideable plug.

Abstract: A catheter for insertion into a body cavity of a subject (such as the urinary bladder), and having a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter; a closure member mountable for sliding movement within the drainage tube between a first position such that said drainage opening is in fluid communication with the drainage outlet and a second position wherein the closure member blocks fluid communication between the drainage opening and the outlet port; and an actuator, operable from the proximal end of the catheter, to move the closure member between the first and second positions. The closure member can comprise a second tube, sliding within the drainage tube, or a slideable plug.

Abstract: Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein said tannins are bound to an anti-cancer agent and/or liposomes containing an anti-cancer agent, together with compositions related thereto.

Abstract: A catheter for insertion into a body cavity of a subject (such as the urinary bladder), and having a drainage tube extending from a drainage opening adjacent a distal end of the catheter to a drainage outlet adjacent a proximal end of the catheter; a closure member mountable for sliding movement within the drainage tube between a first position such that said drainage opening is in fluid communication with the drainage outlet and a second position wherein the closure member blocks fluid communication between the drainage opening and the outlet port; and an actuator, operable from the proximal end of the catheter, to move the closure member between the first and second positions. The closure member can include a second tube, sliding within the drainage tube, or a slideable plug.

Abstract: A catheter (200) for insertion into a hollow viscus of a subject, comprising: a drainage opening (204) and an instillation opening at a distal end an inlet port (209) at a proximal end for instilling a fluid; an outlet port (205) at the proximal end for draining fluid from the viscus; a drainage channel (201) connecting the drainage opening to the outlet port; an instillation channel (211) connecting the inlet port to the instillation opening; a valve (223) proximate the drainage channel at the distal end for closing it against the entry of fluid from the viscus; a valve control port (220) at the proximal end for receiving a control fluid under pressure; and a control channel (222) connecting the valve control port to the valve such that the valve is responsive to admitted control fluid under pressure to close itself.

Abstract: A catheter (200) for insertion into a hollow viscus of a subject, comprising: a drainage opening (204) and an instillation opening at a distal end an inlet port (209) at a proximal end for instilling a fluid; an outlet port (205) at the proximal end for draining fluid from the viscus; a drainage channel (201) connecting the drainage opening to the outlet port; an instillation channel (211) connecting the inlet port to the instillation opening; a valve (223) proximate the drainage channel at the distal end for closing it against the entry of fluid from the viscus; a valve control port (220) at the proximal end for receiving a control fluid under pressure; and a control channel (222) connecting the valve control port to the valve such that the valve is responsive to admitted control fluid under pressure to close itself.