Abstract: The subject technology relates to a cell retention device and method for use in a perfusion cell culture system where the cell retention device includes a hollow-fiber filter having an average pore size ranging from about 0.5 to about 20 ?m and having the ability to operate under perfusion cell culture conditions for up to 35 days without being clogged or losing its product sieving ability by more than 20%.

Abstract: A capacitor and capacitor assemblies are provided, configured to prevent damage from shock and/or vibration. A capacitor assembly according to the invention comprises an anode plate having an anode plate wire extending from a surface of the anode plate. An anode wire holder is positioned around at least a portion of the anode plate wire. A wire separator comprising a channel is provided, at least a portion of the anode plate wire received within the channel. Methods of forming capacitors and capacitor assemblies are also provided.

Abstract: Methods for continuously inactivating virus during manufacture of a biological product are provided. The methods include steps of (1) combining (a) a composition including a biological product, and (b) a composition including a virus-inactivation reagent, to obtain (c) a treatment composition having a predetermined property for inactivation of a virus, (2) confirming that the treatment composition exhibits the predetermined property, (3) transferring the treatment composition to a treatment vessel that includes an inlet, an outlet, and a static mixer, the transferring occurring at the inlet, (4) incubating the treatment composition in the treatment vessel at a predetermined temperature while the treatment composition flows at a predetermined rate and contacts the static mixer, and (5) collecting the treatment composition from the treatment vessel at the outlet, wherein steps (1) to (5) are carried out continuously. Apparatuses and systems including such a treatment vessel are also provided.

Abstract: A capacitor and capacitor assemblies are provided, configured to prevent damage from shock and/or vibration. A capacitor assembly according to the invention comprises an anode plate having an anode plate wire extending from a surface of the anode plate. An anode wire holder is positioned around at least a portion of the anode plate wire. A wire separator comprising a channel is provided, at least a portion of the anode plate wire received within the channel. Methods of forming capacitors and capacitor assemblies are also provided.

Abstract: Methods for continuously inactivating virus during manufacture of a biological product are provided. The methods include steps of (1) combining (a) a composition including a biological product, and (b) a composition including a virus-inactivation reagent, to obtain (c) a treatment composition having a predetermined property for inactivation of a virus, (2) confirming that the treatment composition exhibits the predetermined property, (3) transferring the treatment composition to a treatment vessel that includes an inlet, an outlet, and a static mixer, the transferring occurring at the inlet, (4) incubating the treatment composition in the treatment vessel at a predetermined temperature while the treatment composition flows at a predetermined rate and contacts the static mixer, and (5) collecting the treatment composition from the treatment vessel at the outlet, wherein steps (1) to (5) are carried out continuously. Apparatuses and systems including such a treatment vessel are also provided.

Abstract: Locking clips are provided for attaching a lamp assembly in a traffic signal housing. The clips use a fixed first portion and a movable second portion. The second portion locks to the first portion or to the housing itself and retains an edge of the lamp assembly, holding it in a window of the housing. Foldable/hinged interlocking clips are provided. Other alternatives include slidable clips that engage a fixed element on the housing (e.g. a fixed pin, or a trough in the housing wall), and rotatable clips that engage a fixed element on the housing (e.g. a fixed pin, or a trough in the housing wall). The clips may be part of a retaining system or a traffic signal. Optional lower holders may also be provided. The invention also includes a method for replacing a lamp assembly in a traffic signal housing with at least one locking clip.

Abstract: Locking clips are provided for attaching a lamp assembly in a traffic signal housing. The clips use a fixed first portion and a movable second portion. The second portion locks to the first portion or to the housing itself and retains an edge of the lamp assembly, holding it in a window of the housing. Foldable/hinged interlocking clips are provided. Other alternatives include slidable clips that engage a fixed element on the housing (e.g. a fixed pin, or a trough in the housing wall), and rotatable clips that engage a fixed element on the housing (e.g. a fixed pin, or a trough in the housing wall). The clips may be part of a retaining system or a traffic signal. Optional lower holders may also be provided. The invention also includes a method for replacing a lamp assembly in a traffic signal housing with at least one locking clip.

Abstract: A system provides for high level disinfection or sterilization of an endoscope having a first portion adapted for immersion and a second portion not adapted for immersion. The system includes a container having a first basin sized and adapted to receive the first portion of the endoscope for immersion, a separate and adjacent second basin sized and adapted to receive the second portion of the endoscope, a wall between the first basing and the second basin, and a trough in an upper portion of the wall between the first basin and second basin through which a tube connecting the first portion of the endoscope and the second portion of the endoscope may extend.

Abstract: A system provides for high level disinfection or sterilization of an endoscope having a first portion adapted for immersion and a second portion not adapted for immersion. The system includes a container having a first basin sized and adapted to receive the first portion of the endoscope for immersion, a separate and adjacent second basin sized and adapted to receive the second portion of the endoscope, a wall between the first basing and the second basin, and a trough in an upper portion of the wall between the first basin and second basin through which a tube connecting the first portion of the endoscope and the second portion of the endoscope may extend.

Abstract: Devices and methods for introducing a gas into a liquid are provided. Embodiments of the subject devices include spargers that have an inner member having a gas inlet opening and a gas outlet opening and an outer member that has at least one sparge hole. Embodiments of the subject methods include operatively positioning a sparger having an inner member and an outer member having at least one sparge hole inside a liquid held within a vessel and directing gas into the second member from the first member to cause the gas to exit the at least one sparger hole of the second member. Novel systems and kits are also provided.