Abstract: The present invention concerns the use of immunoassays for the characterisation, diagnosis, screening and monitoring of cancer and other diseases. In particular said immunoassays involve the use of polyclonal and monoclonal antibodies against different regions in tissue factor, particularly urinary tissue factor, and methods for generating the same. Preferably said antibodies are specific for the tissue factor signal transduction peptide region (anti-TF-STP antibodies). In particular, the present invention relates to antibodies and the use thereof which are specific for phosphorylated isoforms of TF-STP. The invention further concerns use of these anti-TF-STP antibodies to quantitate TF-STP isoforms in biological fluids, in particular urine.

Abstract: Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

Abstract: A caged rodent trap assembly catches a rodent by placing bait within a cage to make it harder for the rodent to escape. The assembly includes a platform. A jaw is pivotally coupled to the platform and pivotable between an open position and a closed position. A biasing member is coupled to the jaw and configured to bias the jaw toward a front edge of the platform such that the jaw is forced downwardly against an animal to be caught. A hold-down bar is mechanically coupled to the jaw and configured to retain the jaw in the open position. A trigger plate is positioned above the top surface and configured for receiving bait thereon. The jaw is pivoted onto the animal when pressure is applied to the trigger plate. A cage is coupled to the trigger plate and configured to inhibit the animal's access to the bait.

Abstract: Methods of synthesis of scyllitol diborate and related compounds are provided, including methods that are performed in all-aqueous solutions. Also provided are methods in which the reaction products are recycled to increase the efficiency of the process. The methods include the steps of conversion of a solution of inositol to scyllitol, conversion of scyllitol in the solution to scyllitol diborate, and isolation of the scyllitol diborate from the solution. The scyllitol diborate is reacted to form substantially pure scyllitol diborate, and the remaining solution is efficiently recycled to scyllitol diborate, then to additional substantially pure scyllitol. This scyllitol diborate recycling step can be applied to a variety of processes to improve the yield of scyllitol. The methods are highly efficient and result in large scale reaction products of high purity.

Abstract: Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

Abstract: Methods of synthesis of scyllitol diborate and related compounds are provided, including methods that are performed in all-aqueous solutions. Also provided are methods in which the reaction products are recycled to increase the efficiency of the process. The methods include the steps of conversion of a solution of inositol to scyllitol, conversion of scyllitol in the solution to scyllitol diborate, and isolation of the scyllitol diborate from the solution. The scyllitol diborate is reacted to form substantially pure scyllitol diborate, and the remaining solution is efficiently recycled to scyllitol diborate, then to additional substantially pure scyllitol. This scyllitol diborate recycling step can be applied to a variety of processes to improve the yield of scyllitol. The methods are highly efficient and result in large scale reaction products of high purity.

Abstract: A method, system, and computer program product code for dynamically refreshing user credentials in a distributed processing environment. The present invention provides for fast, local refresh of credentials by a server if the credentials expire during an on-going secure operation. This technique avoids the need for rolling back the operation and requiring the client to restart after acquiring fresh credentials. The ability for a systems administrator to invalidate credentials which have been compromised is maintained.

Abstract: Methods, systems and computer program products are provided which allow “bootstrapping” of credentials by a client application using the well known certificate authority SSL capabilities of another installed application, such as a browser. A first secured session is established between the client and a server which has a certificate including a digital signature from a well known certificate authority. For example, a hypertext transport protocol over SSL (HTTPS) session may be established to the server by a browser such as Netscape™ or Internet Explorer™. An additional public key, or public key ring is then downloaded from the server to the client which may be subsequently used by the client to establish SSL sessions with servers that do not have a certificate from a well known certificate authority.

Abstract: A method, system, and computer program product code using a two-tiered cache for hierarchically structured data. The present invention significantly reduces the frequency of computationally intense processing used to retrieve hierarchically structured data and reduces the system cache storage requirements for maintaining coalesced images.

Abstract: A method, system, and computer program for securely sharing log-in credentials among trusted browser-based applications. Credentials for a user are automatically shared only among a restricted and authorized set of trusted applications, without requiring the application developer to write code to manage the credentials. A single log-in is used to obtain the user credentials for a particular codebase, and the credentials are then reused for applications in that codebase. The Java sandbox concept is exploited to provide this restricted sharing, such that the credentials are stored in the shared static data area associated with the server and codebase from which the set of trusted applications was downloaded.