Patents by Inventor Scott H. Kaufmann

Scott H. Kaufmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for killing HIV-infected cells using Bcl-2 inhibitors
    Patent number: 11938098
    Abstract: This document provides methods and materials involved in killing HIV infected cells (e.g., CD4 T cells). For example, methods and materials for using one or more Bcl-2 inhibitors (e.g., ABT-199) alone or in combination with one or more agents capable of reactivating HIV (e.g., latency reversing agent) to kill HIV infected cells (e.g., CD4 T cells) are provided.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: March 26, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Andrew D. Badley, Amy M. Nguyen, Scott H. Kaufmann, Yuan-Ping Pang, Haiming Dai
  • METHODS AND MATERIALS FOR KILLING HIV INFECTED CELLS
    Publication number: 20210379086
    Abstract: This document provides methods and materials involved in killing HIV infected cells (e.g., CD4 T cells). For example, methods and materials for using one or more Bcl-2 inhibitors (e.g., ABT-199) alone or in combination with one or more agents capable of reactivating HIV (e.g., latency reversing agent) to kill HIV infected cells (e.g., CD4 T cells) are provided.
    Type: Application
    Filed: March 16, 2021
    Publication date: December 9, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Andrew D. Badley, Amy M. Nguyen, Scott H. Kaufmann, Yuan-Ping Pang, Haiming Dai
  • METHODS FOR TREATING OVARIAN CANCER
    Publication number: 20210047645
    Abstract: Materials and methods for using minicircles against ovarian cancer mRNA targets, to prevent metastasis, are provided herein.
    Type: Application
    Filed: May 8, 2019
    Publication date: February 18, 2021
    Inventors: Scott H. Kaufmann, Saravut J. Weroha, Cordelia D. McGehee, Rachel M. Hurley, Annapoorna Venkatachalam, Andrea E. Wahner Hendrickson, Jamie Bakkum-Gamez
  • METHODS OF DETECTING APOBEC3 EXPRESSION AND PREDICTING CLINICAL OUTCOMES
    Publication number: 20190085405
    Abstract: This disclosure describes a kit for determining the level of APOBEC3 in a sample of a subject, and a method for making an anti-APOBEC3 antibody/APOBEC3 complex. This disclosure further describes methods of determining a prognosis of a subject having a cancer using APOBEC3 expression and, in some instances, providing treatment based on the prognosis.
    Type: Application
    Filed: March 23, 2017
    Publication date: March 21, 2019
    Inventors: Reuben S. Harris, Brandon C. Leonard, Scott H. Kaufmann
  • METHODS AND MATERIALS FOR KILLING HIV INFECTED CELLS
    Publication number: 20180161347
    Abstract: This document provides methods and materials involved in killing HIV infected cells (e.g., CD4 T cells). For example, methods and materials for using one or more Bcl-2 inhibitors (e.g., ABT-199) alone or in combination with one or more agents capable of reactivating HIV (e.g., latency reversing agent) to kill HIV infected cells (e.g., CD4 T cells) are provided.
    Type: Application
    Filed: April 20, 2016
    Publication date: June 14, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Andrew D. Badley, Amy M. Nguyen, Scott H. Kaufmann, Yuan-Ping Pang, Haiming Dai
  • METHODS AND MATERIALS FOR ASSESSING ENZYME-NUCLEIC ACID COMPLEXES
    Publication number: 20170003289
    Abstract: Materials and methods for assessing the presence, absence, and/or amount of an enzyme-nucleic acid complex in a sample are provided. Also provided are materials and methods for making and using an anti-enzyme-nucleic acid covalent complex antibody.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Daniel A. Harki, Scott H. Kaufmann, Angela Lyn Perkins-Harki
  • Methods and materials for assessing responsiveness to PARP inhibitors and platinating agents
    Patent number: 8729048
    Abstract: This document provides methods and materials involved in assessing responsiveness to PARP inhibitors and platinating agents. For example, methods and materials for using levels of non-homologous end-joining pathway members (e.g., artemis mRNA or polypeptide levels, Ku80 mRNA or polypeptide levels, or DNA-PKcs mRNA or polypeptide levels) to determine if cancer cells that are homologous recombination-deficient are likely to be susceptible or resistant to PARP inhibitors and platinating agents are provided.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: May 20, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Scott H. Kaufmann, Anand G. Patel
  • Methods and materials for assessing enzyme-nucleic acid complexes
    Patent number: 8530172
    Abstract: This document relates to methods and materials involved in assessing samples for enzyme-nucleic acid complexes. For example, methods and materials for using antibodies to determine the presence, absence, or amount of enzyme-nucleic acid complexes (e.g., human topoisomerase I-DNA complexes) in a sample (e.g., a biological sample such as a tissue biopsy) are provided.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: September 10, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Scott H. Kaufmann, Anand G. Patel
  • Method of treating mantle cell lymphoma
    Patent number: 8507518
    Abstract: This invention provides the use of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) in the treatment or inhibition of mantle cell lymphoma.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: August 13, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Thomas E. Witzig, Scott H. Kaufmann
  • METHODS AND MATERIALS FOR ASSESSING ENZYME-NUCLEIC ACID COMPLEXES
    Publication number: 20110287441
    Abstract: This document relates to methods and materials involved in assessing samples for enzyme-nucleic acid complexes. For example, methods and materials for using antibodies to determine the presence, absence, or amount of enzyme-nucleic acid complexes (e.g., human topoisomerase I-DNA complexes) in a sample (e.g., a biological sample such as a tissue biopsy) are provided.
    Type: Application
    Filed: May 19, 2011
    Publication date: November 24, 2011
    Inventors: Scott H. Kaufmann, Anand G. Patel
  • METHOD OF TREATING MANTLE CELL LYMPHOMA
    Publication number: 20110184010
    Abstract: This invention provides the use of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) in the treatment or inhibition of mantle cell lymphoma.
    Type: Application
    Filed: April 1, 2011
    Publication date: July 28, 2011
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Thomas E. Witzig, Scott H. Kaufmann