Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Abstract: A gas blender with auxiliary mixed gas outlet for mixing a primary gas, generally air, and a secondary gas, generally oxygen, to obtain a mixed gas having several controlled characteristics. The gas blender may be incorporated into a Continuous Positive Airway Pressure (CPAP) device. The gas blender controls the mixing to produce the mixed gas having a predetermined mixture setpoint, generally an oxygen percentage, and a predetermined control setpoint, generally a pressure setpoint or flow rate setpoint. The gas blender provides an auxiliary mixed gas source for use by an auxiliary piece of equipment such as a nebulizer or resuscitation bag. The gas blender includes a primary gas inlet passageway, a secondary gas inlet passageway, a gas mixing apparatus, a mixed gas distribution passageway with an auxiliary mixed gas outlet, a gas sensor, a delivery sensor, a mixed gas delivery control valve, a mixed gas controlled passageway, and a controller.

Abstract: A gas blender with auxiliary mixed gas outlet for mixing a primary gas, generally air, and a secondary gas, generally oxygen, to obtain a mixed gas having several controlled characteristics. The gas blender may be incorporated into a Continuous Positive Airway Pressure (CPAP) device. The gas blender controls the mixing to produce the mixed gas having a predetermined mixture setpoint, generally an oxygen percentage, and a predetermined control setpoint, generally a pressure setpoint or flow rate setpoint. The gas blender provides an auxiliary mixed gas source for use by an auxiliary piece of equipment such as a nebulizer or resuscitation bag. The gas blender includes a primary gas inlet passageway, a secondary gas inlet passageway, a gas mixing apparatus, a mixed gas distribution passageway with an auxiliary mixed gas outlet, a gas sensor, a delivery sensor, a mixed gas delivery control valve, a mixed gas controlled passageway, and a controller.

Abstract: A heated humidifier including an autofeed mechanism disposed within a humidifier chamber. The autofeed mechanism includes a housing, a float, a stem, and a sealing body. The housing defines an inlet, an outlet, a first chamber connected to the inlet, and a second chamber connected to the outlet and the first chamber by a channel. The float moves within the second chamber with the stem projecting therefrom and through the channel. The sealing body is within the first chamber and cooperates with the stem. In an open state, the sealing body is displaced from the channel to permit filling of the humidifier chamber. In a closed state, the sealing body seals the channel to prevent liquid flow to the outlet. A location of the sealing body relative to the channel is controlled by the float as a function of a humidifier chamber liquid level.

Abstract: A gas blender with auxiliary mixed gas outlet for mixing a primary gas, generally air, and a secondary gas, generally oxygen, to obtain a mixed gas having several controlled characteristics. The gas blender may be incorporated into a Continuous Positive Airway Pressure (CPAP) device. The gas blender controls the mixing to produce the mixed gas having a predetermined mixture setpoint, generally an oxygen percentage, and a predetermined control setpoint, generally a pressure setpoint or flow rate setpoint. The gas blender provides an auxiliary mixed gas source for use by an auxiliary piece of equipment such as a nebulizer or resuscitation bag. The gas blender includes a primary gas inlet passageway, a secondary gas inlet passageway, a gas mixing apparatus, a mixed gas distribution passageway with an auxiliary mixed gas outlet, a gas sensor, a delivery sensor, a mixed gas delivery control valve, a mixed gas controlled passageway, and a controller.

Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.

Abstract: A heated humidifier including an autofeed mechanism disposed within a humidifier chamber. The autofeed mechanism includes a housing, a float, a stem, and a sealing body. The housing defines an inlet, an outlet, a first chamber connected to the inlet, and a second chamber connected to the outlet and the first chamber by a channel. The float moves within the second chamber with the stem projecting therefrom and through the channel. The sealing body is within the first chamber and cooperates with the stem. In an open state, the sealing body is displaced from the channel to permit filling of the humidifier chamber. In a closed state, the sealing body seals the channel to prevent liquid flow to the outlet. A location of the sealing body relative to the channel is controlled by the float as a function of a humidifier chamber liquid level.

Abstract: An autofeed mechanism for controlling the flow and level of a fluid. The mechanism includes a body with an inlet chamber and a float chamber. A seat permits fluid communication between the two chambers. A float and a ball cooperate to permit, or deny, access to the seat. Fluid first enters the inlet and fills the chamber and then enters the float chamber by passing through the seat and exiting via the exit. Initially, the weight of the float keeps the ball away from the seat, but eventually the fluid level rises high enough that the action of the float on the ball decreases to a level that is overcome by the buoyant force of the ball and other fluidic forces resulting in the ball moving away from the ball support. Finally, the ball rises enough to seal against the seat thus stopping the flow of fluid.

Abstract: A compressor suitable for use in a portable oxygen concentrator. In one exemplary embodiment, the compressor includes a crankshaft rotatable about a central axis and a plurality of diaphragm assemblies spaced apart around the central axis generally within a plane. The diaphragm assemblies include diaphragms movably mounted to respective housings to at least partially define chambers. A plurality of rods extend between respective diaphragms and the crankshaft. The rods are coupled to the crankshaft such that the rods are offset axially from one another along the central axis and are coupled to the diaphragms for cyclically increasing and decreasing pressure within the chambers as the crankshaft rotates about the central axis.

Abstract: An autofeed mechanism for controlling the flow and level of a fluid. The mechanism includes a body with an inlet chamber and a float chamber. A seat permits fluid communication between the two chambers. A float and a ball cooperate to permit, or deny, access to the seat. Fluid first enters the inlet and fills the chamber and then enters the float chamber by passing through the seat and exiting via the exit. Initially, the weight of the float keeps the ball away from the seat, but eventually the fluid level rises high enough that the action of the float on the ball decreases to a level that is overcome by the buoyant force of the ball and other fluidic forces resulting in the ball moving away from the ball support. Finally, the ball rises enough to seal against the seat thus stopping the flow of fluid.

Abstract: A portable oxygen concentrator includes a pressure swing absorption system defined by a relatively rigid housing adapted to generate a flow of oxygen enriched gas and a battery adapted to provide power to the pressure swing absorption system. The oxygen concentrator has a total weight of less than about 10 lbs, has a maximum flow of 100% O2 equivalent gas of about 0.9 lpm, has a total volume less than about 800 in3, and gas a battery life of at least about 8 hours. The present invention also using a liquefaction or transfill system in combination with such an oxygen concentrator.

Abstract: A gas blender with auxiliary mixed gas outlet for mixing a primary gas, generally air, and a secondary gas, generally oxygen, to obtain a mixed gas having several controlled characteristics. The gas blender may be incorporated into a Continuous Positive Airway Pressure (CPAP) device. The gas blender controls the mixing to produce the mixed gas having a predetermined mixture setpoint, generally an oxygen percentage, and a predetermined control setpoint, generally a pressure setpoint or flow rate setpoint. The gas blender provides an auxiliary mixed gas source for use by an auxiliary piece of equipment such as a nebulizer or resuscitation bag. The gas blender includes a primary gas inlet passageway, a secondary gas inlet passageway, a gas mixing apparatus, a mixed gas distribution passageway with an auxiliary mixed gas outlet, a gas sensor, a delivery sensor, a mixed gas delivery control valve, a mixed gas controlled passageway, and a controller.

Abstract: A portable oxygen concentrator includes a pair of sieve beds having first and second ends, a compressor for delivering air to the first ends of the sieve beds, a reservoir communicating with the second ends of the sieve beds, and an air manifold attached to the first ends of the sieve beds. The air manifold includes passages therein communicating with the compressor and the first ends of the sieve beds. A set of valves is coupled to the air manifold, and a controller is coupled to the valves for selectively opening and closing the valves to alternately charge and purge the sieve beds to deliver concentrated oxygen into the reservoir. An oxygen delivery manifold communicates with the second ends of the sieve beds for delivering oxygen from the reservoir to a user. Pressure sensors may be provided in the reservoir and/or delivery line for controlling operation of the controller.

Abstract: A portable oxygen concentrator includes a pair of sieve beds having first and second ends, a compressor for delivering air to the first ends of the sieve beds, a reservoir communicating with the second ends of the sieve beds, and an air manifold attached to the first ends of the sieve beds. The air manifold includes passages therein communicating with the compressor and the first ends of the sieve beds. A set of valves is coupled to the air manifold, and a controller is coupled to the valves for selectively opening and closing the valves to alternately charge and purge the sieve beds to deliver concentrated oxygen into the reservoir. An oxygen delivery manifold communicates with the second ends of the sieve beds for delivering oxygen from the reservoir to a user. Pressure sensors may be provided in the reservoir and/or delivery line for controlling operation of the controller.

Abstract: A portable oxygen concentrator includes a pair of sieve beds having first and second ends, a compressor for delivering air to the first ends of the sieve beds, a reservoir communicating with the second ends of the sieve beds, and an air manifold attached to the first ends of the sieve beds. The air manifold includes passages therein communicating with the compressor and the first ends of the sieve beds. A set of valves is coupled to the air manifold, and a controller is coupled to the valves for selectively opening and closing the valves to alternately charge and purge the sieve beds to deliver concentrated oxygen into the reservoir. An oxygen delivery manifold communicates with the second ends of the sieve beds for delivering oxygen from the reservoir to a user. Pressure sensors may be provided in the reservoir and/or delivery line for controlling operation of the controller.

Abstract: The present invention provides a heat and moisture exchange (HME) unit that includes a housing having a fibrous media in the housing that is designed to absorb and retain moisture and heat from exhaled air passing through the housing. The HME unit is designed to transfer the moisture and heat to inhaled air passing through the HME unit. The HME unit has an internal bypass in the housing to enable air to pass through the heat HME unit without passing through the fibrous media. The present invention also provides a breathing circuit that includes a medication bypass HME unit, a medication treatment device and a ventilator that is connected in a closed system.

Abstract: The present invention provides a heat and moisture exchange (HME) unit that includes a housing having a fibrous media in the housing that is designed to absorb and retain moisture and heat from exhaled air passing through the housing and transfer the moisture and heat to inhaled air passing through the heat and moisture exchange unit. The heat and moisture exchange unit has an internal bypass in the housing to enable air to pass through the heat and moisture exchange unit without passing through the fibrous media. The present invention also provides a breathing circuit that includes a medication bypass heat moisture exchange unit, a medication treatment device and a ventilator that is connected in a closed system.