Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: Transportation-based service share systems and methods are disclosed herein. An example method can include receiving a request from a service provider to reserve a ridehail vehicle for a ridehail having a time frame, the request specifying a service provided by the service provider; determining the ridehail vehicle for the service provider based on the service; and dispatching the ridehail vehicle, the service provider rendering the service during the ridehail.

Abstract: Matrimony (Mtrm) acts as a negative regulator of Polo kinase (Polo) during the later stages of G2 arrest. Indeed, both the repression of Polo expression until stage 11 and the inactivation of newly synthesized Polo by Mtrm until stage 13 play critical roles in maintaining and properly terminating G2 arrest. Our data suggest a model in which the eventual activation of Cdc25 by an excess of Polo at stage 13 triggers NEB and entry into prometaphase. In view of the foregoing, methods for modulating oocyte maturation are provided. More particularly, methods are provided for in vitro maturation of an oocyte. Further provided are methods for identifying functional orthologs of a Drosophila Matrimony polypeptide, as well as inhibitors thereof.

Abstract: Methods and computer readable media are disclosed related to installing and distributing multiple software products. Computer code necessary to install multiple, related but distinct software products is stored on the storage media and includes at least some primary code that is necessary to all software products installable from a storage medium or set of media. Installation of a specific software product includes the installation of the primary code and at least some product-specific code. Installation is performed by an installer that identifies and installs the appropriate software product based on information, such as a product key, provided by the user. The installer may use a lookup table to identify the code to install and verify that the user is entitled to the software product.

Abstract: The present invention relates to methods for using an Axs gene and related mutants, as well as the proteins or amino acid sequences expressed therefrom. The present invention includes methods for predicting meiotic nondisjunction using an Axs mutant, as well as methods for destroying defective oocytes, using either an Axs mutant or an Axs gene. The present invention pertains to methods for selecting wild-type gametes in individuals with chromosomally based pathologies through the use of the Axs, and Axs related nucleic acid sequences and the proteins therefrom.