Abstract: Medical devices, medical systems, and related methods are provided which may be used in detecting and treating anomalies in a vessel (e.g., in an artery). In one embodiment, a guidewire is provide with multiple sensors spaced apart from one another in a desired spacing. The sensors may each be configured to simultaneously detect a pressure within the vessel at their individual location within a single, common heartbeat of a patient. In one embodiment, information from the sensors may be mapped with other data or information (e.g., imaging data) to assist a healthcare professional in determining if interventional treatment is desired and, if so, what treatment may be most effective.