Patents by Inventor Scott Hultgren

Scott Hultgren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACINETOBACTER VACCINE AND METHOD OF USE THEREOF
    Publication number: 20260191944
    Abstract: The present disclosure provides for a vaccine comprising an Acinetobacter adhesin protein or fragment thereof and a pharmaceutically acceptable carrier or adjuvant. The vaccine may be used for treating or preventing a urinary tract infection (UTI) in a subject in need thereof, particularly a catheter-associated UTI (CAUTI). In some embodiments, the Acinetobacter adhesin protein or fragment thereof is an isolated Acinetobacter chaperone-usher pathway (CUP) adhesin protein or immunogenic fragment thereof.
    Type: Application
    Filed: December 5, 2023
    Publication date: July 9, 2026
    Applicant: Washington University
    Inventors: Scott HULTGREN, Morgan TIMM, Kevin TAMADONFAR, Ali ELLEBEDY, Jerome PINKNER, Mario FELDMAN, Karen DODSON
  • Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of a disease involving gram-positive bacteria
    Patent number: 12472168
    Abstract: The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 9, 2022
    Date of Patent: November 18, 2025
    Assignees: Quretech Bio AB, Washington University in St. Louis
    Inventors: Scott Hultgren, Jerome S. Pinkner, Michael Gordon Caparon, Jr., Ana Lidia Flores Mireles, Fredrik Almqvist, Pardeep Singh, Anders Lindgren, Aaron James Leonard Lynch
  • FIMH INHIBITING COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20250304662
    Abstract: Among the various aspects of the present disclosure is the provision of FimH inhibiting compositions and methods of use thereof. FimH inhibiting compositions that target and inhibit FimH, including monoclonal antibodies, are described. Methods of identifying FimH inhibiting antibodies are also described. Further, a method of treating bacterial infections, including urinary tract infections, is described.
    Type: Application
    Filed: April 1, 2025
    Publication date: October 2, 2025
    Applicant: Washington University
    Inventors: Scott Hultgren, Ali Ellebedy, Edward Lopatto, Karen Dodson, Jerome Pinkner, Morgan Timm, Shaza Sayed Ahmed, Isabella Fox, Denise Sanick, Nathaniel Gualberto, Andrew Kau, Jesus Santiago-Borges, Aaron Schmitz, Jackson Turner
  • Compounds and methods for treating bacterial infections
    Patent number: 11773127
    Abstract: The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: October 3, 2023
    Assignee: Washington University
    Inventors: Vasilios Kalas, James W. Janetka, Scott Hultgren, Jerry Pinkner, Amarendar Maddirala, Vishnu Damalanka
  • RING-FUSED THIAZOLINO 2-PYRIDONES, METHODS FOR PREPARATION THEREOF AND THEIR USE IN THE TREATMENT AND/OR PREVENTION OF A DISEASE INVOLVING GRAM-POSITIVE BACTERIA
    Publication number: 20230233536
    Abstract: The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 9, 2022
    Publication date: July 27, 2023
    Inventors: Scott Hultgren, Jerome S. Pinkner, Michael Gordon Caparon, Ana Lidia Flores Mireles, Fredrik Almqvist, Pardeep Singh, Anders Lindgren, Aaron James Leonard Lynch
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20230033327
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: August 26, 2022
    Publication date: February 2, 2023
    Inventors: James W. JANETKA, Zhenfu HAN, Scott HULTGREN, Jerry PINKER, CORINNE CUSUMANO
  • RING-FUSED THIAZOLINO 2-PYRIDONES, METHODS FOR PREPARATION THEREOF AND THEIR USE IN THE TREATMENT AND/OR PREVENTION OF A DISEASE INVOLVING GRAM-POSITIVE BACTERIA
    Publication number: 20210401815
    Abstract: The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, optionally in combination with a drug against a disease involving gram-positive bacteria.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 30, 2021
    Inventors: Scott Hultgren, Jerome S. Pinkner, Michael Gordon Caparon, Jr., Ana Lidia Flores Mireles, Fredrik Almqvist, Pardeep Singh, Anders Lindgren, Aaron James Leonard Lynch
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20210171563
    Abstract: The present invention is directed to various compounds, compositions, and methods for treating bacterial infections such as urinary tract infections.
    Type: Application
    Filed: November 8, 2018
    Publication date: June 10, 2021
    Applicant: Washington University
    Inventors: Vasilios Kalas, James W. Janetka, Scott Hultgren, Jerry Pinkner, Amarendar Maddirala, Vishnu Damalanka
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20210122776
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: December 28, 2020
    Publication date: April 29, 2021
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • STRUCTURAL BASIS FOR OUTER MEMBRANE USHER ACTIVATION TO CATALYZE P PILUS ASSEMBLY
    Publication number: 20200345707
    Abstract: Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that disrupt the intramolecular interactions of the pilus subunits thereby reducing pilus assembly.
    Type: Application
    Filed: January 27, 2020
    Publication date: November 5, 2020
    Inventors: Scott HULTGREN, Natalie OMATTAGE, Fredrik ALMQVIST, Jerome PINKNER, Karen DODSON, Peng YUAN
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20190211045
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 10273260
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 30, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20180194792
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 12, 2018
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 9957289
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: May 1, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20170247401
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: December 8, 2016
    Publication date: August 31, 2017
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 9567362
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: February 14, 2017
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20160145289
    Abstract: The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused by bacteria containing type 1 pili and FimH. The present invention also encompasses compounds and methods for treating inflammatory bowel disease specifically Crohn's Disease.
    Type: Application
    Filed: May 30, 2014
    Publication date: May 26, 2016
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20150197538
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: December 15, 2014
    Publication date: July 16, 2015
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerry Pinkner, Corinne Cusumano
  • Compounds and methods for treating bacterial infections
    Patent number: 8937167
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: January 20, 2015
    Assignee: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    Publication number: 20120309701
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Application
    Filed: April 23, 2012
    Publication date: December 6, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano