Abstract: The present invention relates to novel compounds of Formulae I-XI: wherein each A, A?, Q, Q?, W, Rw, Y, and Z, and -- are as defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.

Abstract: Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured.

Abstract: Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured.

Abstract: A method for delivering a drug into tissue includes the steps of: providing a drug delivery device having at least one nozzle and a drug contained in a portion of the device; identifying a site for delivery of the drug in or on tissue; placing a portion of the device on or near the site; and delivering the drug into the tissue at the site through at least one nozzle of the device under microjet propulsion.

Abstract: Methods and systems are described to obtain and analyze a gas sample from a desired section of the breath of a person, while accounting for erratic, episodic or otherwise challenging breathing patterns that may otherwise make the capturing of a gas sample from the desired section of breath difficult. These techniques may provide more reliable, accurate and adequate samples of gas such as end-tidal gas, and ultimately an accurate analysis of the sample captured.

Abstract: A method for making a jet injection drug delivery device wherein the drug delivery device has at least one drug reservoir and at least one injection nozzle includes the steps of: identifying a drug desired to be delivered; identifying a volume of the drug desired to be delivered; establishing a reservoir diameter for the at least one drug reservoir; establishing a nozzle diameter for the at least one injection nozzle; identifying a tissue model for delivery of the drug; identifying a penetration depth in the tissue model for the delivery of the drug; and injecting the drug into the tissue model under variable pressure until the desired penetration depth is achieved. The method also includes identifying an optimal pressure range for the drug delivery device that achieves the desired penetration depth.

Abstract: The present invention provides a pneumatic injector that includes a pressurized gas source, an actuator, a driver, and a dispenser. The dispenser of the injector includes a reservoir for containing a desired amount of a chosen medicament and a needle, such as a hypodermic needle, suitable for subcutaneous, intramuscular, or intra-articular delivery of the chosen medicament. The actuator actuates the transmission of pressurized gas from the pressurized gas source to the driver, and as pressurized gas is delivered to the driver, the driver exerts at least an injection force. The injection force is of sufficient magnitude to expel a chosen medicament through the needle of the dispenser within a desired amount of time.

Abstract: An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, thereby causing the release of the beneficial agent over time. The osmotic delivery system has a membrane material that allows a controlled amount of fluid to enter from an exterior of the capsule, while preventing the compositions within the capsule from passing out of the capsule. The osmotic delivery system is designed to meet at least the operating pressures of 1000 psi. The membrane material is cast, calendered or extruded followed by machining (i.e., die-cutting, stamping or otherwise cutting to shape) to provide a uniform nonribbed membrane material. The capsule also includes a membrane material-retaining means that is positioned at a fluid uptake end to retain the membrane material within the capsule, even under periods of high pressure.

Abstract: The present invention provides a syringe cartridge that is sufficiently robust to be used in autoinjectors that generate injection forces sufficient to deliver viscous medicaments. The syringe cartridge of the present invention includes a syringe, a bias mechanism, and a casing. The casing of the syringe cartridge of the present invention includes a collapsible portion and a fixed portion. Advantageously, the collapsible portion of the casing collapses within the fixed portion of the casing as the syringe is driven through its stroke within the syringe cartridge. As the collapsible portion collapses within the fixed portion, the length of the syringe cartridge is effectively reduced, which, in turn, allows the use of a shorter plunger and thereby facilitates the construction of a more compact autoinjector.

Abstract: The present invention provides a syringe cartridge that is sufficiently robust to be used in autoinjectors that generate injection forces sufficient to deliver viscous medicaments. The syringe cartridge of the present invention includes a syringe, a bias mechanism, and a casing. The casing of the syringe cartridge of the present invention includes a collapsible portion and a fixed portion. Advantageously, the collapsible portion of the casing collapses within the fixed portion of the casing as the syringe is driven through its stroke within the syringe cartridge. As the collapsible portion collapses within the fixed portion, the length of the syringe cartridge is effectively reduced, which, in turn, allows the use of a shorter plunger and thereby facilitates the construction of a more compact autoinjector.

Abstract: The present invention provides a pneumatic injector that includes a pressurized gas source, an actuator, a driver, and a dispenser. The dispenser of the injector includes a reservoir for containing a desired amount of a chosen medicament and a needle, such as a hypodermic needle, suitable for subcutaneous, intramuscular, or intra-articular delivery of the chosen medicament. The actuator actuates the transmission of pressurized gas from the pressurized gas source to the driver, and as pressurized gas is delivered to the driver, the driver exerts at least an injection force. The injection force is of sufficient magnitude to expel a chosen medicament through the needle of the dispenser within a desired amount of time.

Abstract: An osmotic delivery system for controlled delivery of a beneficial agent includes an implantable capsule containing a beneficial agent and an osmotic engine that swells on contact with water, to thereby cause the release of the beneficial agent over time. The osmotic delivery system has a membrane material that allows a controlled amount of fluid to enter from an exterior of the capsule, while preventing the compositions within the capsule from passing out of the capsule. The osmotic delivery system is designed to meet at least the operating pressures of 1000 psi. The membrane material is cast, calendered or extruded followed by machining (i.e. die-cutting, stamping or otherwise cutting to shape) to provide a uniform non-ribbed membrane material. The capsule also includes a membrane material retaining means that is positioned at a fluid uptake end to retain the membrane material within the capsule, even under periods of high pressure.

Abstract: A portable apparatus for measuring the electrochemical characteristics of a sample is disclosed. A disposable cartridge, including a plurality of interconnected flow chambers, houses a printed circuit board substrate upon which reference and indicating electrodes are formed. The electrodes are employed in the presence of chemical reagents to aid in the electrochemical determination of a sample undergoing analysis. A thermal sensing element is in close proximity to the electrodes to permit the correction of the measurement for variations in temperature. After a pH value has been determined, the used cartridge can be mechanically ejected thus eliminating user exposure to the blood sample being measured. In this way, the pH of a blood sample can be determined quickly, effectively, inexpensively and with a minimum amount of sample and reagent preparation.