Patents by Inventor Scott Jakes

Scott Jakes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent probes for use in protein kinase inhibitor binding assay
    Patent number: 7588899
    Abstract: The invention provides methods relating to a screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kd for the inhibitor compound is derived based on the Kd of the probe for the kinase and the dose response of the inhibitor agent. The invention also provides active site probes suitable for use with the screening method.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: September 15, 2009
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Anthony S. Prokopowicz, III, Martha Priscilla Brown, Jessi Marie Wildeson, Scott Jakes, Mark E. Labadia
  • 1,6 NAPHTHYRIDINES USEFUL AS INHIBITORS OF SYK KINASE
    Publication number: 20080114024
    Abstract: Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    Type: Application
    Filed: January 15, 2008
    Publication date: May 15, 2008
    Inventors: Charles CYWIN, Scott Jakes, Joachim Heider, Mark Bobko, Renee Des Jarlais, Mark Player, James Rinker, Michael Winters, Bao-ping Zhao
  • Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S
    Patent number: 7348159
    Abstract: This invention relates to screening assay methods that can be applied to broad members of the protein kinase gene family and are useful in the detection and evaluation of kinase inhibitors.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: March 25, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jeffrey David Yingling, Scott Jakes, Donna Terenzio
  • Fluorescent probes for use in protein kinase inhibitor binding assay
    Publication number: 20060263841
    Abstract: The invention provides methods relating to a novel screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kd for the inhibitor compound is derived based on the Kd of the probe for the kinase and the dose response of the inhibitor agent. The invention also provides novel active site probes suitable for use with the screening method.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 23, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Anthony Prokopowicz, Martha Brown, Jessi Wildeson, Scott Jakes, Mark Labadia
  • Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S
    Publication number: 20060240499
    Abstract: This invention relates to screening assay methods that can be applied to broad members of the protein kinase gene family and are useful in the detection and evaluation of kinase inhibitors.
    Type: Application
    Filed: April 20, 2005
    Publication date: October 26, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jeffrey Yingling, Scott Jakes, Donna Terenzio
  • Fluorescent probes for use in protein kinase inhibitor binding assay
    Patent number: 7125996
    Abstract: The invention provides methods relating to a novel screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kd for the inhibitor compound is derived based on the Kd of the probe for the kinase and the dose response of the inhibitor agent. The invention also provides active site probes suitable for use with the screening method.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: October 24, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Anthony S. Prokopowicz, III, Martha Priscilla Brown, Jessi Marie Wildeson, Scott Jakes, Mark E. Labadia
  • Fluorescent probes for use in protein kinase inhibitor binding assay
    Publication number: 20050100978
    Abstract: The invention provides methods relating to a novel screening assay format that can be applied to broad members of the protein kinase gene family. The assay uses a series of labeled, active site probes described herein that can be displaced by an inhibitor agent. The Kd for the inhibitor compound is derived based on the Kd of the probe for the kinase and the dose response of the inhibitor agent. The invention also provides novel active site probes suitable for use with the screening method.
    Type: Application
    Filed: September 30, 2004
    Publication date: May 12, 2005
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Anthony Prokopowicz, Martha Brown, Jessi Wildeson, Scott Jakes, Mark Labadia