Abstract: Provided herein are Camptothecin Conjugates, Camptothecin-Linker Compounds, Camptothecin Compounds, intermediates thereof, and method of preparing the same. Also provided herein are methods of treating cancer and autoimmune diseases with the Conjugates described herein.

Abstract: A system for conducting a beverage tasting event includes a plurality of beverage containers, a plurality of distinct identifiers, a plurality of distinct covers, and a set of instruction materials. The set of instruction materials instructs a first participant to privately assign a correspondence between each distinct beverage and a distinct identifier, and to privately transfer distinct beverages into beverage containers with the distinct identifiers visibly displayed in accordance with each assigned correspondence.

Abstract: An antimicrobial device, such as a flashlight, lantern, or lamp, is discussed herein. The antimicrobial device produces light in the ultraviolet (UV) spectrum (i.e., 150-250 nm), including 200-230 nm. The antimicrobial device includes an electron source, an extractor, and a target material. The electron source provides the electrons of sufficient energy to cause a photon to be released, whether by a target or by the electron itself. The extractor extracts the electrons from the electron source. The target material is a component at which the electron is directed. The target material can release a photon having a desired wavelength or within a desired wavelength range or cause the electron to release a photon having a desired wavelength or within a desired wavelength range.

Abstract: Antibody conjugates with camptothecin compounds are described, with methods of use and preparations.

Abstract: An electrochemical cell includes a plurality of working electrode zones disposed, and defining a pattern, on a surface of the cell and at least one auxiliary electrode disposed on the surface. The auxiliary electrode having a defined interfacial potential.

Abstract: Nasal implants are provided that have a planar type profile with open spaces through portions of the planar type profile. The nasal implant can be compressible along one or more dimensions of the nasal implant, such as the width and length of the planar type profile. Delivery tools for deploying the nasal implants within the nasal tissue are also provided. Methods for deploying the nasal implants within the nasal tissue of the patient are also provided.

Abstract: According to at least one embodiment, a method, a computer system, and a computer program product for enhanced dynamic braking of a tape storage device during a loss of power is provided. The present invention may include identifying a direction in which tape is moving; identifying a position of the tape; setting brake/coast conditions, wherein the brake/coast conditions comprise a BrakeSelect value of a supply reel and a BrakeSelect value of a take-up reel, based on the identified direction in which the tape is moving and the identified position of the tape; and based upon a detection of a loss of power, applying the set brake/coast conditions to the supply reel and the take-up reel.

Abstract: Antibody conjugates with camptothecin compounds are described, with methods of use and preparations.

Abstract: The present invention relates to antibody-drug conjugates comprising an antibody that binds to CEACAM5 conjugated to a drug, such as a Topoisomerase I inhibitor. Also provided herein are methods of treating cancer comprising administering such ADCs.

Abstract: The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or improves biodistribution into the tumor tissue in comparison to normal tissue homogenate from the same species, wherein the normal tissue is the site of an adverse event associated with administration to a human subject in need thereof of a therapeutically effective amount of a comparator conjugate whose amino acid sequence is a dipeptide known to be selectively cleavable by Cathepsin B.

Abstract: A system for conducting a beverage tasting event includes a plurality of beverage containers, a plurality of distinct identifiers, a plurality of distinct covers, and a set of instruction materials. The set of instruction materials instructs a first participant to privately assign a correspondence between each distinct beverage and a distinct identifier, and to privately transfer distinct beverages into beverage containers with the distinct identifiers visibly displayed in accordance with each assigned correspondence.

Abstract: A system for conducting a beverage tasting event includes a plurality of beverage containers, a plurality of distinct identifiers, a plurality of distinct covers, and a set of instruction materials. The set of instruction materials instructs a first participant to privately assign a correspondence between each distinct beverage and a distinct identifier, and to privately transfer distinct beverages into beverage containers with the distinct identifiers visibly displayed in accordance with each assigned correspondence.

Abstract: Nasal implants are provided that have a planar type profile with open spaces through portions of the planar type profile. The nasal implant can be compressible along one or more dimensions of the nasal implant, such as the width and length of the planar type profile. Delivery tools for deploying the nasal implants within the nasal tissue are also provided. Methods for deploying the nasal implants within the nasal tissue of the patient are also provided.

Abstract: Ligand Drug conjugate compounds comprising a ?-glucuronide-based linker and methods of using such compounds are provided.

Abstract: Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.

Abstract: The present invention relates to antibody-drug conjugates comprising an antibody that binds to CEACAM5 conjugated to a drug, such as a Topoisomerase I inhibitor. Also provided herein are methods of treating cancer comprising administering such ADCs.

Abstract: The invention relates to conjugates of biologically active compounds, wherein such a conjugate is comprised of a sequence of amino acids containing a tripeptide that confers selective cleavage by tumor tissue homogenate for release of free drug and/or improves biodistribution into the tumor tissue in comparison to normal tissue homogenate from the same species, wherein the normal tissue is the site of an adverse event associated with administration to a human subject in need thereof of a therapeutically effective amount of a comparator conjugate whose amino acid sequence is a dipeptide known to be selectively cleavable by Cathepsin B.

Abstract: Techniques for a modeling platform associated with simulating risk models. According to certain aspects, systems and methods include simulating the impact of qualitative assumptions on the risk model. Accordingly, the risk model may include a hierarchical tree formed of component qualitative assumption objects and quantitative assumption objects. Quantitative assumption objects include indications of distribution function parameters associated with the assumption object and qualitative assumption objects include an indication of an impact on a parent quantitative assumption. When simulating the risk model, systems and methods may adjust sampled values quantitative assumption object when a child qualitative assumption object is enabled.

Abstract: Techniques for a modeling platform associated with simulating risk models. According to certain aspects, systems and methods include simulating the risk model over time. The risk model may include a hierarchical tree formed of component assumption objects associated with distribution functions. The systems and methods may apply a time function to generate time-adjusted values for the component assumption objects corresponding to defined distribution functions. The systems and methods may then combine the time-adjusted values to generate time-adjusted values for parent assumption objects.

Abstract: A system for generating a custom audio experience that is configured receive a first audio sample of a first impulse response corresponding to an interior of a vehicle, generate a first convolution reverb from the first audio sample, receive a second audio sample of a second impulse response corresponding to an audio equipment of the vehicle, generate an impulse response module from the second audio sample, generate combination module based on the first convolution reverb and the impulse response module, receive a third audio sample from a user, modify the third audio sample based on the combination module to generate a modified third audio sample, receive an indication of user input to play the modified third audio sample, and cause a user device to output the modified third audio sample.