Patents by Inventor Scott K. Shore

Scott K. Shore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multi-unit ribozyme inhibition of oncogene gene expression
    Patent number: 5635385
    Abstract: A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles such as liposomes, and growth factor conjugates for cellular uptake by receptor-mediated endocytosis, are also described. The multi-unit ribozyme is used for the treatment of neoplasms characterized by expression of the oncogene. In one embodiment, a multi-unit ribozyme is provided which cleaves the mRNA transcript of Philadelphia chromosome-positive cells, thereby blocking production of the tumorigenic p210.sup.bcr-abl fusion protein.
    Type: Grant
    Filed: September 15, 1993
    Date of Patent: June 3, 1997
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: Lance H. Leopold, Scott K. Shore, Moole V. R. Reddy, E. Premkumar Reddy