Abstract: A repellent delivery device may include a body having a hygroscopic base material, and one or more of an insecticide, and an insect repellent. The repellent delivery device may have a support structure coupled between the body and a trunk of a plant. The body may be configured to release the one or more of the insecticide and the insect repellant into a root ball of the plant using ambient moisture.

Abstract: An IPC device is over a pole in a ground surface adjacent a plant. The IPC device includes an upper end having a sealed apex and partially defining a plant-receiving cavity therein, a lower tubular end opposite the upper end and also partially defining the plant-receiving cavity therein, and a medial seam coupling the upper end and the lower tubular end. The upper end and the lower tubular end each has a major mesh surface. The lower tubular end includes a first end and a second end opposite the first end, the first end being coupled to the medial seam. The lower tubular end also partially defines the plant-receiving cavity therein. The IPC device also includes a curved flexible support carried by the medial seam.

Abstract: The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

Abstract: A plant cover device comprises an enclosure having mesh material to define a plant-receiving cavity. The enclosure includes a first mesh section having a closed top end, and a first perimeter opposite the closed top end, and a second mesh section having a second perimeter attached to the first perimeter of the first mesh section, and a bottom end opposite the closed top end of the first mesh section defining a trunk receiving opening. The plant cover device also includes a support extending vertically from a ground surface through the first and second perimeters and to abut the closed top end of the enclosure.

Abstract: An IPC device may include a pole in a ground surface. The IPC device also includes an upper end with tapered walls extending inwardly from a base and into an apex to abut the pole, and a seam extending along a peripheral edge of the tapered walls. The upper end defines a plant-receiving cavity. The IPC device also includes a lower tubular end opposite the upper end and having a first end, a second end opposite the first end, and a major mesh surface extending between the first end and the second end. The lower tubular end also defines the plant-receiving cavity therein. The IPC also includes a medial seam coupling the base of the upper end and the first end of the lower tubular end. The IPC also includes a curved flexible support carried by the medial seam. The IPC also includes a base member.

Abstract: The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful for inhibiting ERK1/2. By administering to a patient in need a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, Z, J, M, and R1 to R8 are defined herein, these compounds are effective in treating conditions associated with dysregulation of the RAS/RAF/MEK/ERK pathway. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer.

Abstract: A plant cover apparatus includes a bag having an interior encompassed by a wall that extends from a top end of the bag and tapers inwardly to a bottom end of the bag. The bottom end includes a rim that laterally circumscribes a plant-receiving opening formed through the bag. The bag has a slot that extends vertically from the opening through the wall. The slot includes opposed margins having cooperatively interlocking parts that can temporarily be joined and separated to increase the size of the opening. The bag may be vertically suspended from a support member positioned next to the plant. An exterior perimeter of the bag may be rigid enough to help the bag maintain its shape when suspended.

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.

Abstract: The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.

Abstract: A plant cover device may include an enclosure having an upper end, a lower tubular end opposite the upper end, and a medial seam coupling the upper end and the lower tubular end. The upper end may include panels coupled together to partially define a plant-receiving cavity therein. Each of the panels may have a major mesh surface, and a panel seam extending along a peripheral edge of the major mesh surface, adjacent panels being coupled together at respective panel seams. The lower tubular end may include a major mesh surface and having a first end and a second end opposite the first end, the first end being coupled to the medial seam. The lower tubular end may also partially define the plant-receiving cavity therein. The enclosure may have a curved flexible support carried by the medial seam, and a pole extending vertically from a surface to an apex of the enclosure.

Abstract: The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful for inhibiting ERK1/2. By administering to a patient in need a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, Z, J, M, and R1 to R8 are defined herein, these compounds are effective in treating conditions associated with dysregulation of the RAS/RAF/MEK/ERK pathway. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer.

Abstract: A plant cover apparatus includes a bag having an interior encompassed by a wall that extends from a top end of the bag and tapers inwardly to a bottom end of the bag. The bottom end includes a rim that laterally circumscribes a plant-receiving opening formed through the bag. The bag has a slot that extends vertically from the opening through the wall. The slot includes opposed margins having cooperatively interlocking parts that can temporarily be joined and separated to increase the size of the opening. The bag may be vertically suspended from a support member positioned next to the plant. An exterior perimeter of the bag may be rigid enough to help the bag maintain its shape when suspended.

Abstract: A plant cover device may include an enclosure having an upper end, a lower tubular end opposite the upper end, and a medial seam coupling the upper end and the lower tubular end. The upper end may include panels coupled together to partially define a plant-receiving cavity therein. Each of the panels may have a major mesh surface, and a panel seam extending along a peripheral edge of the major mesh surface, adjacent panels being coupled together at respective panel seams. The lower tubular end may include a major mesh surface and having a first end and a second end opposite the first end, the first end being coupled to the medial seam. The lower tubular end may also partially define the plant-receiving cavity therein. The enclosure may have a curved flexible support carried by the medial seam, and a pole extending vertically from a surface to an apex of the enclosure.

Abstract: A plant cover device (630, 730) may include an enclosure (631, 731) having panels (204, 634A) coupled together to define a plant-receiving cavity. Each of the panels (204, 634A) has a major mesh surface (635A), and a seam (208, 302, 636A) extending along a peripheral edge (646A) of the major mesh surface (635A), Adjacent panels (634A) are coupled together at respective seams (636A). The enclosure (631, 731) may include a first fastener (637, 640) adjacent the peripheral edge (646A) of a respective panel (634A, 634B). The plant cover device (630, 730) may have a base (100, 632) coupled to the enclosure (631, 731) and including a solid major surface (638) extending radially outward, and a second fastener (637, 640) carried by the solid major surface (638) and extending radially. The plant cover device (630, 730) may also include a support (633, 733) extending vertically from a ground surface to an apex of the enclosure (631, 731).

Abstract: An IPC device may include a pole in a ground surface. The IPC device also includes an upper end with tapered walls extending inwardly from a base and into an apex to abut the pole, and a seam extending along a peripheral edge of the tapered walls. The upper end defines a plant-receiving cavity. The IPC device also includes a lower tubular end opposite the upper end and having a first end, a second end opposite the first end, and a major mesh surface extending between the first end and the second end. The lower tubular end also defines the plant-receiving cavity therein. The IPC also includes a medial seam coupling the base of the upper end and the first end of the lower tubular end. The IPC also includes a curved flexible support carried by the medial seam. The IPC also includes a base member.

Abstract: A plant cover apparatus includes a bag having an interior encompassed by a wall that extends from a top end of the bag and tapers inwardly to a bottom end of the bag. The bottom end includes a rim that laterally circumscribes a plant-receiving opening formed through the bag. The bag has a slot that extends vertically from the opening through the wall. The slot includes opposed margins having cooperatively interlocking parts that can temporarily be joined and separated to increase the size of the opening. The bag may be vertically suspended from a support member positioned next to the plant. An exterior perimeter of the bag may be rigid enough to help the bag maintain its shape when suspended.

Abstract: The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

Abstract: The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.

Abstract: A crankshaft damper for attachment to one end of a crankshaft of an engine. The crankshaft damper includes an elastomeric member attached to a hub, and an inertia ring connected to the hub through the elastomeric member. Several different structures for cooling the elastomeric member are disclosed that dissipate heat away from the elastomeric member. Air flow is induced near the elastomeric member by providing air flow openings in the inertia ring or the elastomeric member.

Abstract: Embodiments of the disclosure relate generally to formulations, methods, kits, and dosage forms for improved topical pharmaceutical formulation comprising an active ingredient, wherein the active ingredient comprises a compound selected from the group consisting of the Formula (I), Formula (II), and Formula (III): The formulations can further comprise a hydrophilic non-ionic surfactant comprising a poloxamer. These formulations are useful in treating inflammation, pruritus and/or pain, or for treating conditions for which the signs and symptoms include inflammation, pruritis and/or pain, by topical administration to a subject.